Objective:To explore the effects of staged aerobic training with peer support in patients undergoing targeted therapy for breast cancer.Methods:A total of 90 patients with breast cancer who were hospitalized in the Affiliated Hospital of Jining Medical University from March 2021 to March 2022 were selected by convenience sampling and divided into a control group ( n=45) and a research group ( n=45). Patients in the control group received routine nursing care, while those in the research group were given staged aerobic training with peer support based on the nursing care provided to the control group. The 6-min walking distance, step test duration, Pittsburgh Sleep Quality Index (PSQI), Revised Piper Fatigue Scale (RPFS), and Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) scores were statistically compared between the two groups before and after the intervention. Results:After the intervention, the 6-minute walking distance of the research group was longer than that of the control group, and the duration of the step test was longer than that of the control group, with statistically significant differences ( P<0.05) ; the PSQI and RPFS scores of the research group were lower than those of the control group, while the society and family, function, emotion, physiological condition and additional attention scores were higher than those in the control group, with statistically significant differences ( P<0.05) . Conclusions:Staged aerobic training with peer support can improve the body's exercise capacity and cardiorespiratory endurance, reduce cancer-related fatigue, and improve the quality of sleep and life of patients with breast cancer.