Objective To investigate the correlation between serum 25-hydroxyvitamin D[25(OH)D]level and diabetic kidney disease(DKD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 174 T2DM patients admitted to Jiashan County Second People's Hospital from May 2019 to May 2021 were selected and divided into normal albuminuria(NUAlb)group(<30 mg/g,n=71),microalbuminuria(MUAlb)group(30～300 mg/g,n=85)and large albuminuria(LUAlb)group(≥300 mg/g,n=18)according to the urine albumin-creatinine ratio(UACR)level.The levels of 25(OH)D in each group and its relationship with UACR were analyzed.Results The age,DM duration,use of ACEI or ARBs,SBP,DBP,FPG,SUA,proportion of 25(OH)D<30 nmol/L and UACR in NUAlb,MUAlb,LUAlb graup increased in turn(P<0.05).Spearman correlation analysis showed that UACR in T2DM patients was positively correlated with gender,age,DM duration,BMI,SBP,DBP,FPG,HbA1c,TG,and SUA(P<0.05),and negatively correlated with HDL-C and 25(OH)D(P<0.05).Logistic regression analysis showed that gender,SBP,HbA1c,SUA,and 25(OH)D were influencing factors for albuminuria in T2DM patients.Conclusions T2DM patients have 25(OH)D shortage,especially in DKD patients.25(OH)D deficiency is closely related to proteinuria in T2DM patients.

ObjectiveTo observe the clinical efficacy of Qianghuo Shengshitang combined with ozone injection and radiofrequency thermocoagulation target puncture in the treatment of cervical spondylotic radiculopathy （wind-cold blockage type）. MethodSixty-eight patients with cervical spondylotic radiculopathy who were treated in Henan Province Hospital of Traditional Chinese Medicine from August 2020 to May 2021 were included and grouped into a control group and a research group by random number table， with 34 patients in each group. The control group was administrated with placebo granules of Qianghuo Shengshitang， and treated with ozone injection and radiofrequency thermocoagulation target puncture at the same time. The research group was given modified Qianghuo Shengshitang combined with ozone injection and radiofrequency thermocoagulation target puncture. Before and after treatment， patients in two groups were tested for the levels of tumor necrosis factor-α （TNF-α）， procalcitonin （PCT）， interleukin-2 （IL-2）， interleukin-1β （IL-1β）， 6-ketoprostaglandin E1α （6-keto-PGE1α）， plasma substance P （SP）， β-endorphin （β-EP）， lipid peroxide （LPO）， malondialdehyde （MDA）， and superoxide dismutase （SOD）. The pain visual scale （VAS）， cervical dysfunction index （NDI）， and clinical evaluation scale for cervical spondylosis （CASCS） were given to patients to evaluate the clinical efficacy. ResultCompared with those before treatment， the levels of IL-1β， PCT， and TNF-α in two groups were decreased， and the level of IL-2 was increased （P<0.05）. The improvement of IL-1β， PCT， TNF-α， and IL-2 was more obvious in the research group as compared with the control group （P<0.05）. After treatment， the levels of SOD in two groups were increased， while the levels of LPO and MDA were decreased （P<0.05）. After treatment， the improvement of SOD， LPO， and MDA was more obvious in the research group as compared with the control group （P<0.05）. Compared with those before treatment， the levels of SP and 6-keto-PGE1α in two groups were decreased after treatment， and the level of β-EP was increased （P<0.05）. The improvement of -keto-PGE1α and β-EP was more obvious in the research group as compared with the control group after treatment （P<0.05）. Compared with those before treatment， the VAS and NDI scores of the research group were decreased， and the CASCS scores were increased （P<0.05）. After treatment， the improvement of VAS， NDI， and CASCS of the research group was more obvious as compared with the control group （P<0.05）. After treatment， the total effective rate of patients in the research group was higher than that in the control group （Z=2.018， P<0.05）. ConclusionModified Qianghuo Shengshitang combined with ozone injection and radiofrequency thermocoagulation target puncture in the treatment of patients with cervical spondylotic radiculopathy （wind-cold blockage type） can inhibit inflammation， remove oxygen free radicals， improve the level of pain mediators， relieve pain， and improve cervical spine function and clinical efficacy.