Objective To research the effects of alprostadil on nerve conduction velocity and blood flow status of 120 patients with type 2 diabetic peripheral neuropathy.Methods 120 cases of patients with type 2 diabetic peripheral neuropathy in our hospital were selected as the research objects.According to the hospital admission,they were divided into observation group and control group.The control group was treated with Mecobalamin intravenous drip treatment; on the basis of the above treatment,the observation group was treated with alprostadil intravenous drip treatment,and the treatment time was two weeks.To established the relevant clinical curative effect standard for evaluated and compared the clinical therapeutic effect of the two groups.Before and after treatment,compared the nerve conduction velocity and blood flow between the two groups.Results The total effective rate of the observation group was 86.67％,and the control group was 71.67％,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences between the two groups in nerve conduction velocity and blood rheology indexes.After treatment,the median nerve MNSV,common nerve MNSV,median nerve SNCV,common nerve SNCV of the observation group were(54.14±7.29)m/s,(50.22±7.85)m/s,(48.47±7.64m/s and(47.04±6.58m/s respectively,were significantly higher than the control group(50.11±6.85)m/s,(46.24±7.08)m/s,(44.58±7.21)m/s,(43.57±6.55)m/s.The observation group of plasma viscosity,high shear viscosity and low shear viscosity levels were(2.48±0.29)Mpa/s,(4.87±0.41)Mpa/s,(33.46±2.77)Mpa/s,were significantly lower than the control group(2.83±0.33)Mpa/s,(5.23±0.44)Mpa/s,(34.83±2.54)Mpa/s,and the differences between the groups were statistically significant(P<0.05).Conclusion Alprostadil can significantly improve nerve conduction velocity and blood flow condition in patients with type 2 diabetic peripheral neuropathy,has better clinical curative effect.