Basal-like breast cancer (BLBC) is a basal cell phenotype and associated with different levels of expression in basal cell keratin and (or) myoepithelial markers in breast cancer,which has a unique genetic phenotype and morphological characteristics.BLBC is prevalent in young woman,and it is easy to relapse and metastasis. Additionally,most BLBC has expression loss of estrogen receptor and progesterone receptor and human epidermal growth factor receptor 2,which limits the targeted therapeutic options for these predominantly triple-negative breast cancers.

The pathogenesis of malignant lymphoma has been an important topic in tumor research ,but it is still unclear.Recent clinical studies showed that the expression level of Toll -like receptor 4(TLR4)was signif-icantly high in mantle cell lymphoma tissue and a variety of lymphoma cell lines .At the same time,the TLR4 ex-pression level was correlated with prognosis .The Role of TLR4 in malignant lymphoma for occurrence and devel-opment is reviewed in this article ,which may elucidate the pathogenesis and provide a new basis for the therapy of lymphoma.

Objective To explore the efficacy and mechanism of exogenous reduced glutathione(GSH)on cardiotoxicity induced by epirubicin(EPI).Methods 60 postoperative patients with breast cancer were randomly divided into the treatment group and control group with 30 cases in each group.The treatment group received 6 cycles of chemotherapy with CEF regimen plus the reduced GSH.The control group also received 6 cycles of chemotherapy only with CEF alone.The cardiotoxicity of all patients were estimated by the ECG,myocardial enzymes,troponin Ⅰ(cTnⅠ),ultrasoundcardiogram and tissue Doppler technique before hemotherapy and after 3 cycles and 6 cycles of chemotherapy.Results After 3 cycles of chemotherapy,there were no significant differences in ECG,cTnⅠ,left ventricle ejection fraction(EF),fraction shortening(FS),E/A,decline time(DT)and myocardial creatine kinase(CK),isoenzyme of creatine kinase containing M and B subunits(CK-MB),lactate dehydrogenase(LDH)between two groups(P>0.05);While,there was a significant difference in Em/Am between two groups(P<0.01).After 6 cycles of chemotherapy,there were also no significant differences in EF,FS,myocardial CK,CK-MB,LDH between two groups(P>0.05);there were significant differences in ECG,cTnI,E/A,DT and Em/Am between two groups(P<0.01).Conclusion The reduced GSH can prevent the cardiotoxicicy induced by EPI,which may be related with the ability of GSH against the oxidant injury and inhibiting calcium overload.

Objective To explore the relationship between personality and mental status of inpatients in the department of neurology of general hospital.Methods 150 inpatients in the department of neurology had been surveyed by Eysenck Personality Questionnaire(EPQ) and Symptom Checklist-90(SCL-90) with the domestic norm as control.Results The examining results of the inpatients in the department of neurology were as following.The scores of neurotisim(N) of EPQ were higher than that of the domestic norm(P<0.05);the scores of extra-introversion(E) and psychoticism(P) of EPQ were lower than that of the domestic norm(P<0.05).The scores of 7 factors including total scores,somatisation,depression,anxiety,hostility,panic and psychosis in SCL-90 were higher than that of the domestic norm( P<0.05).The N scores of EPQ was positively correlated with all factors of SCL-90,the E scoers of EPQ was positively correlated with hostility and paranoia factor of SCL-90,the P scores of EPQ was positively correlated with paranoia factor of SCL-90.Conclusion The mental characteristics of inpatient in the department of neurology of general hospital in acute period are that the incidence of somatisation,depression,anxiety,panic and psychosis are higher than normal people,compulsion and paranoia are as well as normal people.The character of neurotisim and introversion may be the personality background of it.

Circulating tumor cells (CTCs) are essential for establishing metastasis. Detecting CTCs can help clinicians detect early metastases or recurrences more effectively. Compared with traditional histological analyses and imaging, CTC detection has a much higher reproducibility and sensitivity and can provide more timely prognostic information in human breast cancer.

Triple negative breast cancer is a special subtype of breast cancer , including basal -like breast cancer and unclassified breast cancer .Since it was defined in 2005 ,the differences from other subtypes in biological characteristics and poor prognosis of TNBC have became priorities and hotspots which are researched by epidemiologists ,pathologists and clinicians .According to the research ,the risk factors of TNBC include race ,obe-sity,age,women′s reproductive process,oral contraceptive use,physical activity,abortion history,family history, socio-economic factors and so on .This review focuses on race ,obesity,age,women′s reproductive process ,oral contraceptive use ,according to the latest research results of risk factors of TNBC ,helping healthy people get a bet-ter understanding of TNBC and preventing the incidence of TNBC ,suggesting clinicians combine the biological characteristics and epidemiological features and further instructing people to take precautions .This paper also pro-vides theoretical basis for researcher on the further investigaticans of the etiology of TNBC .

Objective: To detect the correlation of the expression of c-erbB-2, p53, PCNA and bcl-2 with the biological behavior of breast cancer. Methods: We used immunohistochemistry to detect the expression of c-erbB-2, p53, PCNA and bcl-2 in 56 breast cancer patients. Results: The expression of c-erbB-2 was 41.1% and was negatively correlated with histological classification but was not correlated with age, clinical stage, ER, or PR. The expression of p53 was 48.2% and was positively related with ER and PR but was negatively correlated with clinical stage and pathological type. The expression of bcl-2 was 50.0% and was negatively correlated with histological classification, ER and PR and was positively correlated with clinical stage and pathological type. PCNA was highly expressed in the 56 cases. Conclusion: We should combine the detection of c-erbB-2, p53, PCNA and bcl-2 with the evaluation of clinical stage, histological degree and pathological type in order to improve the prognostic estimation of breast cancer.

Objective To investigate the possibility of human papillomavirus late 1 (HPV-L1) protein detection in predicting the prognosis of cervical intraepithelial neoplasia (CIN). Methods (1)Through immunocytochemical method to detect expression of HPV-L1 protein in diagnosis of CIN before treatment. (2) Through hybridization and gene chip technology to detect expression of high-risk human papilloma virus (HR-HPV) in diagnosis of CIN after treatment for twelve months. Results (1) Comparing the three treatment methods in CIN patients, HR-HPV infection sustained no significant difference (P > 0.05). (2) The positive expression rate of HPV-L1 protein was 75.00% in CINⅠand 36.13%in CINⅡ~Ⅲbefore treatment, with statistically significant (P<0.05). (3) Persistent infection rate of HR-HPV was 5.97%in HPV-L1 positive expression group after treatment for twelve months and 19%in HPV-L1 negative expression group. The difference between the two was statistically significant (P<0.05). (4) The expression of HPV-L1 capsid protein before treatment had a negative relationship with HR-HPV persistent infection after 12 months of treatment. Conclusion Detection of HPV-L1 protein before treatment can predict the prognosis of CIN which had been treated.

Background and purpose:Angiogenesis plays an important part in growth and metastases of breast cancer. Nowadays researchers put more concern about whether endocrine therapy adjusts tumor angiogenesis in breast cancer. Here we investigated the regulation of vascular endothelial growth factor(VEGF) expression in breast cancer in response to various stimuli:estradiol(E2) ,ICI182780 and tamoxifen. Methods:We studied the regulation of VEGFmRNA expression in MCF-7 cells stimulated by E2 at different doses and duration by semiquantitative RT-PCR. When ICI182780 and Tamoxifen used alone or in combination with E2,the expression of VEGFmRNA was detected respectively. Results:Dose-dependent experiments indicated that the maximum VEGF mRNA level(0.125?0.006) -(0.112?0.014) was obtained at 1-10 nmol/L.The response of VEGFmRNA expression to E2(1 nmol/L) occurred in a time-dependent manner;the level of VEGF transcripts(0.105?0.009) signifi cantly increased within 2 h and reached a maximum at 6 h(0.140?0.024)(P

OBJECTIVE: To establish a method for the simultaneous determination of the contents of salicylic acid and nitrofural in Fu-La pastes.METHODS: A dual-wavelength spectrophotometry was adopted for the determination of the contents of salicylic acid and nitrofural with water used as solvent.The content of salicylic acid was determined with the detective wavelength set at 296.6 nm and the reference wavelength set at 314.4 nm.The content of the nitrofural was determined directly with the detective wavelength set at 375.0 nm.RESULTS: The linear ranges of salicylic acid and nitrofural were 10.77～43.08 ?g?mL-1(r=0.999 0) and 2.58～10.32 ?g?mL-1(r=1.000 0),respectively;and their average recovery rates were 99.55%(RSD=0.47%) and 100.03%(RSD=0.80%),respectively.CONCLUSION: The method is simple,rapid and accurate,and suitable for the quality control of Fu-La pastes.