Objective To investigate the early diagnostic value of serum neuron‐specific enolase(NSE) in neonaal hypoxic‐is‐chemic encephalopathy(HIE) .Methods Eighty full term neonates with HIE in the neonatology department of our hospital from January 2013 to June 2014 were selected as the observation group and contemporaneous 30 full term neonates without perinatal as‐phyxia as the control group .Serum NSE was detected within 24 h after birth and after 2‐week comprehensive treatment(mainly in‐cluding 10 d ganglioside therapy) .The neonatal patients were divided into the mild HIE in 18 cases ,moderate HIE in 48 cases and severe HIE 14 cases according to the HIE severity .The control group was performed the serum NSE detection within postnatal 24 h .Results The serum NSE level in the mild ,moderate and severe HIE groups was significantly higher than that in the control group(P<0 .05) .The re‐detected results of serum NSE after 2‐week comprehensive treatment in the mild ,moderate and severe HIE groups were significantly decreased when compared with those at admission ,the differences were statistically significant(P<0 .05) .Conclusion Serum NSE is a sensitive biochemical indicator for early diagnosing neonatal HIE ,and also reflect the severity of neonatal HIE .

Objective To examine the joint effects of parent-child relationship and environmental sensitivity(ES)on adolescent mental health from the perspective of sensitivity X family conflict interaction.Methods In 2023,we investigated 7,010 adolescents from six junior high schools in Shaanxi Province,China.Self-reported questionnaires were used to assess parent-child relationship,ES,and adolescent mental health.ES was assessed by Highly Sensitive Child Scale(HSC);Patient Health Questionnaire-9(PHQ-9),Strengths and Difficulties Questionnaire(SDQ),and Happiness index were used to measure depression,externalizing problems,and subjective well-being.Results ① Girls'ES scores were significantly higher than boys'(t=-7.504,P＜0.01).② When predicting depression and externalizing problems,the main effects of parent-child relationship and ES in adolescents were significant(b=-0.263,0.237,0.332,P＜0.001;b=0.201,0.220,P＜0.001),and the interaction between family conflicts and ES was significant(b=-0.072,P＜0.05;b=0.092,P＜0.05).(3)Widaman's confirmatory and competitive approach results showed the significant interaction of sensitivity X family conflict with depression and externalizing problems,which were consistent with the differential susceptibility and diathesis-stress framework,respectively(BIC=2 170.98,2 162.6).Conclusion Adolescents with high environmental sensitivity suffer more from high family conflict and benefit more from low family conflicts.These sensitive adolescents can be described as having developmentally susceptibility rather than vulnerability.

ObjectiveTo analyze the feasibility， reliability and validity of the disability assessment for dementia scale for the elderly. MethodsA total of 290 dementia patients from 17 survey sites in 13 districts and counties of Chengdu were enrolled by convenient sampling method， and they were assessed using demographic data inventory， Mini-Mental State Examination （MMSE）， Neuropsychiatric Inventory （NPI）， Physical Self-Maintenance Scale （PSMS） and disability assessment for dementia scale for the elderly. Cronbach's α coefficient， Spearman-Brown coefficient， Guttman split-half coefficient and test-retest reliability were used to evaluate the internal consistency of above scales. Criterion-related validity of the scale was analyzed based on MMSE， NPI and PSMS. ResultsA total of 276 patients （95.17%） completed valid questionnaires. The intraclass correlation coefficient of the total score and each dimension were between 0.828~0.976， the Spearman-Brown coefficient were between 0.790~0.917， the Guttman split-half coefficient were between 0.812~0.857， and the Cronbach’s α coefficient were between 0.737~0.886. The cognitive function dimension score was positively correlated with the MMSE score （r=0.948， P<0.01）， the mental behavior symptom dimension score was positively correlated with the NPI score （r=0.893， P<0.01）， and the daily living ability dimension score was positively correlated with the PSMS score （r=0.997， P<0.01）. The dimensions scores were positively correlated with the total score of the scale （r=0.634~0.841， P<0.05）. ConclusionDisability of dementia assessment scale has good feasibility， reliability and validity， which is a reliable tool to assess senile dementia and disability.