1.Surgical excision and botulinum toxin A injection for vocal process granuloma.
Lijing MA ; Yang XIAO ; Jingying YE ; Qingwen YANG ; Jun WANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(2):140-143
OBJECTIVE:
To study the efficacy of treatment with microsurgery in combination with local injection of type A botulinum toxin for vocal process granuloma.
METHOD:
28 patients with vocal process granuloma received endotracheal intubation under general anesthesia. The lesion was removed with micro-scissor and CO2 laster under a self-retaining laryngoscope and microscope. The incision and mucous membrane surrounding the wound was closed with 8-0 absorbable suture. 4-point injection of botulinum toxin type A 8-15 u was then performed along the thyroarytenoid muscle and arytenoid muscle of the same side. Postoperative medication was administered based on disease causes.
RESULT:
All patients experienced vocal cord dyskinesia of the injected side 2-3 days after surgery. At 1 month after the surgery, wound healing was good in all the 28 patients, and the vocal cord movement was limited at the injected side. At 3 months, movement of the bilateral vocal cords was normal, and the vocal cord process mucosa was smooth. Patients were followed up for more than a year, and only one patient had recurrence in 2 months after surgery. The cure rate was 96. 4%.
CONCLUSION
Combination of laryngeal microsurgery and type A botulinum toxin local injection can shorten the treatment course of vocal process granuloma.
Anesthesia, General
;
Botulinum Toxins
;
administration & dosage
;
Granuloma
;
drug therapy
;
surgery
;
Humans
;
Injections
;
Intubation, Intratracheal
;
Laryngeal Mucosa
;
Laryngeal Muscles
;
Laryngeal Neoplasms
;
drug therapy
;
surgery
;
Laryngoscopes
;
Larynx
;
Microsurgery
;
Postoperative Period
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Recurrence
;
Vocal Cords
;
Wound Healing
2.Simulation study of the outpatients queuing system under the time-interval controlled appointment registration mode
Qingwen SUN ; Zhiyong WANG ; Jian JIANG ; Min WEI ; Hua YANG
Chinese Journal of Hospital Administration 2012;28(7):510-513
Objective To build a simulation model for outpatients queuing,using data from a general outpatient cardiovascular clinic of a general hospital in Shanghai and different rules in the process.The study employs time-interval controlled mode for appointment registration,for the purpose of analyzing characteristics of different queues.Methods Extraction of data of the clinic in a given month by means of HIS system to determine the parameters of the queuing models.Building the simulation model with Matlab to develop the plan of mixed queues and that of discrete queues,for analyzing the waiting time variations,with different number of doctors on duty and different number of appointments in one time interval.Resnlts In the Monday mornings for example,the mean waiting time of appointments or no-appointments are calculated by simulation with different queuing rules,different number of doctors on duty and different appointment quantities of one time interval.Conclusion The mean waiting times of appointments and no-appointments can be both sizably cut short by means of time-interval controlled appointment; different queuing plans are recommended for different departments; the simulation model should be further verified and optimized in practice.
3.Effect of Group A Streptococcus Preparation combined with mitomycin and lentinan combined with mitomy-cin in the treatment of malignant pleural effusion through intrapleural catheter
Yihui ZHANG ; Jiawei REN ; Qingwen ZHANG ; Ke YANG
Chinese Journal of Primary Medicine and Pharmacy 2016;23(13):1975-1977,1978
Objective To explore the effect and side effects of Group A Streptococcus Preparation(Sapylin)com-bined with mitomycin and lentinan combined with mitomycin in treating malignant pleural effusion through intrapleural catheter.Methods 70 malignant pleural effusion patients were selected in this study.All the patients were randomly divided into Sapylin group and lentinan group.One case with penicillin positive of the Sapylin group was adjusted to enter the lentinan group.After drainage of pleural effusion,the patients were divided into Sapylin group (34 patients) and lentinan group (36 patients).For the Sapylin group,Sapylin was prior injected and mitomycin was posterior injected.For the lentinan group,lentinan was prior injected and mitomycin was posterior injected.The side effects and clinical effect were observed and reported.Results The effective rate of Sapylin group was 85.3%,whereas 83.3%of lentinan group.There was no significant difference between the two groups(χ2 =0.051,P =0.822).Both groups had the following minor side effects:chest pain,fever,vomit and decreased white blood cells.No liver or renal injuries were reported.Conclusion The clinical outcomes of Sapylin combined with mitomycin and lentinan combined with mitomycin are both positive,in addition,the side effects are minor.
4.The Short-term Modulation of Scalp Acupuncture on the Cortical Excitability in Patients with Parkinson's Disease: A Pilot Study
Yuqin LIN ; Xin NIU ; Xuezhi YANG ; Haiyan LI ; Qingwen ZHU
World Science and Technology-Modernization of Traditional Chinese Medicine 2011;(5):830-835
Acupuncture was frequently used for alternative treatments in Parkinson's disease because of its safety,but there was an argument whether acupuncture improves motor symptoms or not.Besides,few electrophysiological studies were designed for acupuncture combined with Parkinson's disease Using the technique of paired transcranial pulse magnetic stimulation,we measured the excitability of corticocortical inhibitory circuits to investigate effects of scalp acupuncture from 9 patients with Parkinson's disease.Although patients didn't take any short-term benefit in motor symptoms through the treatment of scalp acupuncture,there was no any adverse event,and some electrophysical effects developed in patients.The enhanced corticocortical inhibition on motor cortex possibly developed at longer interstimulus intervals,and there was a relatively increase in later part of motor-related cortical potentials on the central part and right-side near vertex around over sensory cortex,but was not significant in early potentials.So a further long-term study is essential to ascertain the physical mechanism and clinical effects in scalp acupuncture.
5.Knowledge base, research front and hot spot analysis of Cu-Zn superoxide dismutase
Yu ZOU ; Yanjun LI ; Shuang YANG ; Qingwen ZHANG
Chinese Journal of Tissue Engineering Research 2015;(42):6861-6867
Abstract BACKGROUND:Studies have found that Cu-Zn superoxide dismutase (SOD1) is associated with familial amyotrophic lateral sclerosis, opening up a new way of studying molecular genetics. So far more than 100 kinds of SOD1 gene mutations have been found. OBJECTIVE:To analyze the hot spot, research front and knowledge base of amyotrophic lateral sclerosis visualy. METHODS:Totaly 4 693 relevant articles published from 2005 to 2014 were retrieved from Web of Science in ISI with “Cu-Zn superoxide dismutase” or “SOD1” as search keywords. With the aid of CiteSpace III software, the visualization mapping of the network in co-cited articles and keywords was drawn to reveal knowledge base, hot spots and research front of SOD1. The parameters include the number of published papers and citations within 10 years, distribution of research countries and institutions, main source journals, research area of highly cited papers, keywords with high-frequency and emerging keywords with high-frequency in recent 5 years. RESULTS AND CONCLUSION:The number of published papers and citations in a year showed a trend of sustained growth. United State, China and Japan rank the top three in this area, in which Chinese Academy of Sciences has a great influence among the research institutions. The research fields of SOD1 focus on neurosciences and neurology, biochemistry and molecular biology and so on. The high impact factors of journals with a large number of articles reflect the importance and innovation of this research. Ten high-cited articles consist of the knowledge base on SOD1, directing to the finding of different sites of SOD1 mutation and the measurement of protein concentrations and activity of SOD. The hot spots of SOD1 mainly focus on oxidative stress, familial amyotrophic lateral sclerosis caused by SOD1 mutation and different types of transgenic animal models. The research fronts mainly focus on the finding of pathogenesis in amyotrophic lateral sclerosis, such as the aggregation of TDP-43, the interaction between astrocytes and motor neurons, optineurin and the inhibitor of nuclear factor-κB, hexanucleotide repeat expansion in C9ORF72 and autophagy.
6.Short-term Modulation of Scalp Acupuncture on Cortical Excitability and Motor-related Cortical Potential
Yuqin LIN ; Xin NIU ; Xuezhi YANG ; Haiyan LI ; Qingwen ZHU
World Science and Technology-Modernization of Traditional Chinese Medicine 2012;(3):1694-1700
This study was aimed to investigate short-term modulation mechanism of scalp acupuncture according to the experimentation of cortical excitability and motor-related cortical potentials in ten normal volunteers.Through scalp needle stimulation in specific theoretical areas related to underlying cerebral surfaces,scalp acupuncture can be used as an effective therapy by changes in relative cerebral function,which is the basic principle.According to the available neurophysiological data in our study,the modulation of scalp acupuncture displayed in late part of motor-related cortical potential noticed mainly in the motor and sensory cortexes,contralateral to the needle stimulate site.Also,acupuncture can develop inhibition at longer interstimulus intervals,in paired pulse magnetic stimulation,from the somatosensory input of contralateral sensory cortex via scalp needle stimulation.In our study,it might be difficult to produce more acupuncture inhibition.The maintaining of scalp needles subcutaneously without other management after achieving needling sensations cannot achieve the requested strength of the acupuncture stimulation.
7.Formulation of the upper limit threshold of fasting urinary calcium to creatinine ratio in healthy premenopausal women in Quzhou,Zhejiang Province
Hongbin YANG ; Qingwen ZHU ; Zhaohui HU ; Zhonghou LIU
Medical Journal of Chinese People's Liberation Army 1981;0(06):-
0.05).Conclusion The upper limit threshold of fasting U-Ca/Cr ratios in healthy premenopausal women is established,which can provide a reference for the bone metabolism of patients on the high-turnover status.
8.Clinical Study on Thyroid Space Occupying Lesion by Ultrasound in Patients with Breast Cancer
Xuejun GUO ; Chunmei MIAO ; Qingwen TANG ; Xuemei JIN ; Yue YANG
Journal of Kunming Medical University 2016;37(11):86-88
Objective To investigate the incidence of thyroid space occupying lesion by ultrasound imaging in patients with breast cancer.Methods From 2009 to 2012,150 patients with breast cancer as experimental group and another 150 patients with breast benign diseases as control group underwent thyroid ultrasound examination.Ultrasound results of the two groups were analyzed to find the differences.Restult More obvious space occupying lesions were found in experimental group than those in control group (P<0.05).Conclusion The incidence rate of thyroid space occupying lesion in the patients with breast cancer is higher than that in the patients with no breast cancer.
9.Study on the relationship between plasma homocysteine and ischemic stroke in young and middle-aged adults
Yanchuan SHI ; Yuehong CHEN ; Min YUAN ; Qingwen HUANG ; Ruiming WU ; Miaoxiong YANG ; Tinghui GUO ; Wenhuo CHEN
Chinese Journal of Primary Medicine and Pharmacy 2012;19(4):499-500
Objective To observe the relationship between plasma level of homocysteine(HCY) and ischemic stroke in young and middle-aged adults,explore the clinical signficance concerning the occurrence and development of ischemic stroke in young and middle-aged adults.Methods The plasma homocysteine level of 132 young and middle-aged adults patients with ischemic and 86 control peoples were measured by means of enzymatic cycling assay.Results The plasma homocysteine level in ischemic stroke was higher than that in control group( P < 0.01 ).The higher the plasma homocysteine level,the larger infarcted focus in acute ischemic stroke group of young and middleaged adults.The plasma homocysteine level and the infarcted focus was positively linearly correlated.Conclusion Hyperhomocysteinemia is a risk factor of ischemic stroke among young and middle-aged adults.The higher the plasma homocysteine level,the larger infarcted focus in acute ischemic stroke group.The plasma homocysteine level can reflect the size of the infarcted focus and the degree of disease,and the plasma homocysteine level should serve as a kind of regular examination or as an index intervention can be taken,all of which are great importance to prevent ischemic stroke and reduce its morbilily.
10.CARDIAC-HEMODYNAMIC EFFECTS OF M3 RECEPTOR AGONIST ON RAT AND RABBIT HEARTS
Yan LIU ; Yue WANG ; Manling MA ; Yan ZHANG ; Houwei LI ; Qingwen CHEN ; Baofeng YANG
Acta Pharmaceutica Sinica 2001;36(2):84-87
AIM To study the activation of choline on M3-R in heart and observe the hemodynamic changes of rat and rabbit. METHODS A cardiac catheter was inserted into the left ventricular cavity via the right carotid artery, then the HR, LVSP, LVEDP, and ±dp/dt were measured using a polygraph system. RESULTS Choline was shown to decrease the hemodynamic assessments, such as HR, +dp/dt, LVSP and LVEDP. while the M3-R antagonist 4-DAMP (4-diphenylacetoxy-N-methylpiperidine-methiodide) showed little effect on these assessments. It was found to reverse the hemodynamic effects of choline. CONCLUSION M3 receptor agonist can produce negative inotropic and chronotropic effects on the heart of rat and rabbit.