Purpose:To study bcl-2 and MDR expressions in renal cell carcinoma and to evaluate its clinical significance.Methods:blc-2 and MDR expression were studied by immunohistochemical technique in 48 specimens of renal cell carcinoma tissues and in 10 normal renal tissues and their clinical significance was analyzed.Results:The positive rate of expression of bcl-2 in the renal cell carcinoma tissue was 77.1%, while it was 40.0% in the normal renal tissue(P＜0.05). However, it was not related to the tumor grade and tumor stage(P＞0.05). On the other hand, There was a positive expression of MDR1 in renal cell carcinoma and normal renal tissue. MDR1 was positively related to tumor cell type(P＜0.05). Compared with the other types of renal cell carcinoma. The granular existed higher expression. Both have no relationship with prognosis.Conclusions: bcl-2 Protein is overexpressed in the majority of renal cell carcinomas. The overexpression of bcl-2 may have a role in tumorigenesis. MDR1, an established predictor for chemo-resistance, however, has no significant correlation with bcl-1. The multidrug resistant of renal cell cancer is probably induced by double-functions of bcl and MDR1.