Multidrug-resistant organism infection seriously affects the treatment and prognosis of ICU patients. The prevention and control of multidrug-resistant organism infection in hospital has become a common focus of clinical care and nursing. The effectiveness of chlorhexidine bathing for the prevention of multidrug-resistant organism infection in ICU patients were reviewed, and outcomes of the review would be expected to offer references to nursing practice and play a guiding role in reducing the incidence of multidrug-resistant organism infection, decreasing the cost of infection control, ensuring the safety of patient care.