U.S.President Barack Obama proposed a precise medical initiative plan in early 2015 which caused widespread concern.According to the definition given by National Cancer Institute,precision medicine is the use of genetic information for the diagnosis or treatment of individual diseases.In the announcement gave by Barack Obama,one of the specific contents in precise medicine,the short-term goals include strengthen the use of precision medicine in cancer treatment,tumor therapy has thus identified as one of the most important concerns in precise medicine,which was given a great hope.As a result,research management personnel in cancer hospital should aware of the great importance of precise medical research,empower themselves by learning related ideas and models of precision medicine,explore the precise medical development related to the management of scientific research in the new theories,new methodologies,new mechanism and new models,in order to play an important role in scientific research management department in the hospital precise medical research to fulfill the coordination and management functions.

Objective To study the prevalence of intraventficular hemorrhage(IVH)in premature infants using bedside cranial ultrasound scans and to analyze the associated laboratory results.Methods 114 patients admitted between February 2003 and March 2004 were eligible for the study.NAS-2000A 3D ultrasound instrument for bedside ultrasound detection were used.All the premature infants were detected for blood gas analysis,blood cell analysis(red blood cell counting,haemoglobin and haematocrit),prothrombin time (PT),fibrinogen(FIB)and activated partial thromboplastin time(APTT)in the first 24 hours of life.Results There were 34 IVH cases in 114 patients(29.8%).The ineidence of IVH of premature infants below 34 weeks gestation was 43.8%,which was higher than that of infants above 35 weeks gestation.The incidence of IVH of infants whose birth weight were below 1 500 g is 58.8%,which was higher than that of infants whose birth weight were above 1 500 g.The incidence of IVH increased with decreasing gestational age and birth weight.As compared with the values of infants without IVH,HB and HCT of the IVH infants were higher (P＜0.05);PT and APTT of the IVH inrants were longer(P＜0.01);hypoxia,hypercapnia and acidosis were more common in IVH infants(P＜0.05).Conclusion Risk factors such as short gestational age,low birth weight,increased HB and HCT,prolongation of PT and APTT,hypoxia,hypercapnia and acidosis may be associated with the IVH in premature infants.

Objective To observe the influence of combined spinal and epidural anesthesia( CSEA) of different po-sitions on the anesthesia effect, anesthesia operation and hemodynamic index during cesarean section of obese par-turients. Methods Eighty obese parturients[BMI≥30] undergoing cesarean section were randomly divided into two groups, that was group A and B, with 40 cases each. In group A, the parturients were required to undergo lat-eral decubitus position with 0.5% ropivacaine hydrochloride of 2. 4 ml. In group B, the parturients were required to undergo sitting position with the same ropivacaine hydrochloride as group A. The following data was recorded, which were the percentage of one-attempt's successful epidural needle placement, the anesthesia level,the anesthe-sia effect and the hemodynamic change. All the complications were also observed,such as the supine hypotension syndrome during operation,headache after spinal anesthesia and postoperative spinal nerve stimulation. ResultsThe difference of anesthetic effect between the two groups was insignificant in statistics while group B's rate of one-attempt successful puncture was higher than gruop A ( P <0.05 ) . The difference of hemodynamic index between them was significant in statistics ( P<0.05 ) with group B's rate of supine hypotension syndrome lower than group A. Conclusion Both body positions have the same anesthtic effect for obese parturients during cesarean section while the puncture operation of sitting positon is easier than lateral decubitus position and the hemodynamic change is also more stable.

Objective To investigate the frequency of type 2 diabetes and diabetic complications. Methods The clinical and laboratory data of 1433 cases of patients with type 2 diabetes mellitus were retrospectively analyzed. Results The frequency of diabetic complications of patients with type 2 diabetes mellitus were 88.28%(1626/1433). The rates of complicated hypertension, coronary heart disease, peripheral neuritis, diabetic renopathy, diabetic retinopathy, hyperlipoidemia, urethritis, diabetic acidosis, pneumonia, fatty liver, diabetic foot gangrene, cholecystitis, skin infection, brain vessel disease and vegetative nerve disease were 46.9%, 33.2%, 29.7%, 25.4%,22.0%,13.0%,7.5%,4.2%,4.0%,4.0%,3.5%,3.5%,3.3%,2.9%,and 2.0%, respectively. Conclusion The frequency of diabetic complications of patients with type 2 diabetes mellitus were much high, and the distrubution of diabetic complications was different in different ages, course of disease and syndromes.

Seven cases of typical salpingian diverticulum were identified by hysterosalpinography (HSG). The differentiation diagnosis of the disease was discussed. HSG is believed to be the method of choice for the diagnosis of this disease.
Adnexal Diseases/*radiography ; Diagnosis, Differential ; Diverticulum/*radiography ; *Fallopian Tubes ; Hysterosalpingography

Objective To study the effects of planting soil on active ingredients in different organs of Lonicera japonica Thunb.. Methods The contents of active ingredients in Lonicera japonica Thunb. from different origins, different varieties and different organs, such as chlorogenic acid, luteoloside, total flavonoids, total phenolic acid, and soil nutrient and inorganic elements, were detected. The data were analyzed by using SPSS 19.0 software. Results Lonicera japonica Thunb. from Pinyi area in Shandong Province had the highest content of active ingredients. In terms of content of active ingredients, PY-HBRD-1 was the most suitable variety in the Pingyi area. Analysis on the correlation between planting soil and active ingredients showed that the contents of K, Mn and other elements could be used as the index for quality control of Lonicera japonica Thunb.. Conclusion This study could provide guidance for selection of varieties of Lonicera japonica Thunb. in different planting areas, and enrich the materials about researches on producing area of Lonicera japonica.

Objective To investigate the application value of chronic kidney disease epidemiology collaboration (CKD-EPI) equations and amendatory equations for calculating glomerular filtration rate (GFR) in Chinese patients with diabetes,including CKD-EPI serum creatinine (Scr) equation (CKD-EPLcr),CKD-EPI serum cystatin C (ScysC) equation (CKD-EPLcysc),combination of CKD-EPLcr and CKD-EPIScrSCysC (CKD-EPISr SCysC),Asian modified CKD-EPI equation (CKD-EPIAsian),Chinese diabetes CKD-EPI equation (CKD-EPIDiabctes),refitted modification of diet in renal disease (MDRD) equation (rMDRD),Cockcroft-Gault equation (CG) and Simplified MDRD equation.Methods Serum creatinine (Scr) was detected using basic picric acid method,serum cystatin C (CysC) was measured by Latex enhanced turbidimetric,and the reference value of GFR was worked out by 99Tcm-DTPA renal dynamic imaging and standardization of body surface area.Relation of Scr,Scysc,GFR measured by every equations and rGFR were analyzed.The accuracy of 30％ of each equation,the consistency and deviation of the evaluation of renal function by each equation were compared.The diagnostic efficacy in GFR＜60 ml/(min · 1.73 m2) was compared using the receiver operating characteristic (ROC) curve.Results The rGFR had negative correlation with Scr、ScysC (both P＜0.001).The rGFR had positive correlation with GFR measured by CKD-EPIScr,CKD-EPIScysC,CKD-EPIS-SCysC,CKD-EPIAsian,CKD-EPIDiabetes rMDRD,CG and Simplified MDRD (all P＜0.001).The coincidence rate between 30％ of rGFR and GFR measured byCKD-EPIDiabetes and simplified MDRD were higher.There was no significant difference of rGFR and GFR measured by CKD-EPIscr,CKD-EPIScysC,CKD-EPIScr-SCysC,CKD-EPIAsian,CKD-EPIDiabetes,rMDRD,CG and Simplified MDRD.GFR measured by CKD-EPIDiabetes has the best consistent degree with rGFR.ROC curve showed that the area under curve of GFR measured by CKD-EPIDiabctes was largest and the Youden index was the highest.Conclusion There are different degrees of deviation in eGFR predicted by the eight kinds of equations.The accuracy and consistency of CKD-EPIDiabetes in Chinese 2-type diabetes is the best.

Objective To investigate the effects of parecoxib pretreatment on the intrapulmonary shunt during one-lung ventilation in patients undergoing esophageal cancer resection.Methods Forty ASA Ⅰ or Ⅱ patients of both sexes,aged 25-64 yr,weighing 45-70 kg,with body height 156-178 cm,undergoing elective esophageal surgery,were randomly divided into 2 groups (n =20 each):normal saline group (group NS) and parecoxib group (group P).Parecoxib 40 mg (in normal saline 10 ml) was injected intravenously 30 min before anesthesia in group P,while the equal volume of normal saline was given instead of parecoxib in group NS.Anesthesia was induced with iv injection of propofol,fentanyl and rocuronium.Bronchial blocker was inserted after tracheal intubation and the correct position was confirmed by bronchoscopy.Anesthesia was maintained with iv infusion of propofol and remifentanil and intermittent iv boluses of atracurium.HR,MAP,SpO2 and mean airway pressure (Pmean)were determined at 5 min of two-lung ventilation,at 40 min of one-lung ventilation,and at 30 min after re-expansion of the collapsed lung (T0-2).Blood samples were taken simultaneously from jugular vein and radial artery for blood gas analysis.Intrapulmonary shunt (Qs/Qt) was calculated.Results There were no significant differences in hemodynamic parameters and Pmean between the two groups (P ＞ 0.05).PaO2 was significantly lower,while Qs/Qt was significantly higher at T1,2 than at T0 in groups NS and P (P ＜ 0.05).PaO2 was significantly higher,while Qs/Qt was significantly lower at T2 than at T1 in groups NS and P (P ＜ 0.05).Qs/Qt was significantly lower at T1,2 and PaO2 was significantly higher at T2 in group P than in group NS (P ＜ 0.05).Conclusion Parecoxib 40 mg injected intravenously at 30 min before anesthesia can reduce the intrapulmonary shunt during one lung ventilation in patients undergoing esophageal cancer resection.

OBJECTIVE To study the main bacteria and their drug-resistance of postoperative infections after liver transplantation.METHODS The distribution and drug-resistance profile of 156 strains of bacterial isolates from(various) specimens in 68 liver transplantation inpatients were retrospectively analyzed last year.RESULTS The(incidence) of infections after liver transplantation was 67.6 %.The major bacteria were Klebsilla pneumoniae((17.3%)),Staphylococcus aureus(14.1%),Candida albicans(11.0%),and Pseudomonas aeruginosa((11.0%)).The bacteria had the character of multidrug-resistance and high drug-resistance.The most effective(antibiotics) to Gram-negatives and Gram-positives were still the carbopenems and glycopeptide.CONCLUSIONS(Infection) is a major complication after liver transplantation.Prevention,early diagnosis and treatment of the(infection) are very important.

Objective To assess the effects of orthotopic liver transplantation (OLT) on the quality of life (QoL) of the patients with end stage liver disease. Methods QoL of OLT recipients was assessed by the GLQI index of the digestive system disease. A total of 43 recipients with benign end stage liver disease without operational complications, who were clearly conscious and had no difficulty in comprehending the investigation table because of their relative good education above the middle school, had been investigated during May 2000 to December 2002. The detecting data were divided into three parts including before OLT, at discharge, and 3 months after discharge. Results At the stage of discharge, QoL of OLT recipients was improved as compared with that before OLT. The physical function, psychological status, symptom of the recipients had been significantly improved than as compared with those before OLT ( P 0.05). And at the stage of 3 months after discharge, QoL of the recipients was improved significantly than that in the hospital ( P