1.Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation.
Xiang YANG ; Hongxiao WANG ; Enjun XIE ; Biyao TANG ; Qingdian MU ; Zijun SONG ; Junyi CHEN ; Fudi WANG ; Junxia MIN
Protein & Cell 2020;11(12):915-920
Amino Acid Substitution
;
Antineoplastic Agents/pharmacology*
;
Cell Line, Tumor
;
Drug Resistance, Neoplasm/genetics*
;
Gastrointestinal Neoplasms/pathology*
;
Humans
;
MAP Kinase Signaling System/genetics*
;
Mutation, Missense
;
Receptor, ErbB-3/metabolism*
;
Receptor, Fibroblast Growth Factor, Type 1/metabolism*