1.Therapeutic effect of comprehensive rehabilitation nursing on patients with cerebral infarction compli-cated type 2 diabetes mellitus
Min FANG ; Zhongmei LIU ; Qing CHEN
Chinese Journal of cardiovascular Rehabilitation Medicine 2014;23(4):469-471
Objective:To explore the therapeutic effect of comprehensive rehabilitation nursing on patients with cere-bral infarction (CI)complicated type 2 diabetes mellitus (T2DM).Methods:According to number table,a total of 118 CI + T2DM patients were randomly and equally divided into comprehensive nursing group and routine nursing group.Comprehensive nursing group received comprehensive nursing based on routine nursing.The evaluating inde-xes included fasting blood glucose (FBG)concentration,limb muscle strength recovery and score of activity of daily living of two groups before hospitalization and discharge.Results:Compared with routine treatment group before discharge,there was significant reduction [(7.9±4.2)mmol/L vs.(5.9±2.8)mmol/L]in FBG concentration in comprehensive nursing group;limb muscle strength recovery of comprehensive nursing group was significantly better than that of routine nursing group (≥ grade III,upper limb 83.1% vs.64.4%,lower limb 76.3% vs.55.9%);percentage of patients with activity of daily living score > 60 scores (33.9%)in comprehensive nursing group was significantly higher than that of routine nursing group (15.2%),P <0.05 all. Conclusion:Comprehensive rehabili-tation nursing could promote the rehabilitation of physical function in patients with cerebral infarction complicated type 2 diabetes mellitus.
2.Clinical characteristics and prognostic factors of esophageal spindle cell carcinoma
Guangjie LIU ; Qing CAO ; Shiwei LIU ; Fang LIU ; Qingyi LIU
Journal of Medical Postgraduates 2015;(2):170-174
Objective Esophageal spindle cell carcinoma is a rare type of esophageal squamous cell carcinoma , which was usually named esophageal carcinosarcoma .This article was to discuss the clinical characteristics , treatment and prognostic factors of e-sophageal spindle cell carcinoma . Methods The clinical and pathological data of 28 cases of esophageal spindle cell carcinoma were retrospectively analyzed .The prognostic factors was analyzed for various factors including gender , age, smoking history , tumor loca-tion, tumor size, lymph node metastasis, histological type, pathological staging and adjuvant treatment regimen .Kaplan-Meier method was applied to calculate the survival rate , log rank method for single prognostic factor analysis and Cox proportional hazard regression model for multivariate analysis of prognosis . Results One-year, three-year, and five-year survival rates were 89.3%(25/28), 67.1%(19/28), 38.5%(10/28)respectively.Single factor analysis showed that the pathological type , N stage, T stage, pTNM stage were the factors influencing the prognosis(P﹤0.05), while gender, age, smoking and drinking history, tumor location, tumor size, operation incision selection , adjuvant treatment regimen were not .Multivariate analysis showed pTNM stage were the independent fac-tors affecting the prognosis of esophageal spindle cell carcinoma (χ2 =13.104, P=0.000). Conclusion Esophageal spindle cell carcinoma is a rare kind of esophageal squamous cell carcinoma with less invasiveness , low rate of lymph node metastasis and good progno-sis.Radical operation is the preferred treatment .
3.Correlation between carcinoma-associated fibroblasts and breast cancer.
Ya-qing LI ; Shuai LI ; Fang-fang LIU ; Li FU
Chinese Journal of Pathology 2012;41(2):142-144
Actins
;
metabolism
;
Angiotensins
;
pharmacology
;
Animals
;
Breast Neoplasms
;
blood supply
;
drug therapy
;
metabolism
;
pathology
;
Cell Proliferation
;
Female
;
Fibroblasts
;
metabolism
;
pathology
;
physiology
;
Humans
;
Interferon-gamma
;
therapeutic use
;
Neoplasm Invasiveness
;
Neoplasm Metastasis
;
Neovascularization, Pathologic
;
Prognosis
;
Transforming Growth Factor beta1
;
metabolism
4.Correlation between the inflammatory factors and adipocytokines with gestational diabetes mellitus and their change in puerperium
Tao LIU ; Zhen FANG ; Dong YANG ; Qing LIU
Chinese Journal of Obstetrics and Gynecology 2012;47(6):436-439
Objective To investigate the relationship between inflammatory factors,including C-reactive protein( CRP),tumor necrosis factor alpha (TNF-α),adiponectin,leptin and gestational diabetes mellitus (GDM) and their changes in puerperiunr Methods From June 2008 to May 2010,40 cases with gestational diabetes mellitus,40 cases of normal pregnancy were enrolled in this study.Fasting venous blood were obtained at early pregnancy (10 - 12 weeks),late pregnancy (36 -38 weeks) and day 3 and 42 of postpartum.Serumal adiponectin,leptin and TNF-α were measured by ELISA,and serumal CRP were measured by particle enhanced immunoturbidimetric method.The levels of those 4 cytokines and homeostasis model assessment insulin resistance (HOMA-IR) index were compared between two groups.And the changes of 4 cytokines were calculated in puerperium.The receiver operating characteristic (ROC) for TNF-α predicting GDM was designed.Results ( 1 ) The relationship between cytokines and HOMA-IR:the levels of adiponectin of (5.7 ± 1.8 ) mg/L in the GDM group were significantly lower than ( 8.1 ± 2.7 ) mg/L in control group in early pregnancy,and the level of adiponectin was negatively correlated with HOMA-IR (r=-0.333,P<0.05).The levels of (28 ± 10) μg/L of leptin,( 10.0 ±3.4) ng/L of TNF-α and (4.7 ± 1.1 ) mg/L of CRP in GDM group were significantly higher than ( 20 ± 8 ) μ,g/L of leptin,(4.6 ±2.7) ng/L of TNF-α,(2.4 ± 1.2 ) mg/L of CRP in control group,which were positively correlated with HOMA-IR ( r =0.411,0.529,0.308,all P < 0.05 ).In late pregnancy,the level of adiponectin ( 3.9 ±2.2) mg/L in the GDM group was significantly lower than ( 6.6 ± 2.7 ) mg/L in control group,and the level of adiponectin was negatively correlated with HOMA-IR ( r =- 0.344,P < 0.05 ).The levels of ( 37 ±13) μg/L of leptin,( 12.7 ±2.6) ng/L of TNF-α and (6.7 ±3.6) mg/L of CRP in the GDM group were significantly higher than ( 30 ± 13 ) μg/L of leptin,(5.8 ± 2.1 ) ng/L of TNF-α,( 4.4 ± 3.1 ) mg/L of CRP in control group,which were positively correlated with HOMA-IR (r =0.414,0.487,0.285,all P <0.05).Multiple linear regression analysis showed that the level of TNF-α at early and late pregnancy was most correlated with HOMA-IR ( r =0.390,0.284,all P < 0.05 ).( 2 ) The level of the cytokines and HOMA-IR in puerperium:at day 3 of postpartum,the level of adiponectin of (3.3 ± 1.1) mg/L in the GDM group was significantly lower than (6.2 ± 1.5 ) mg/L in control group,which was negatively correlated with HOMA-1R (r =- 0.283,P < 0.05 ).The levels of ( 31 ± 13 ) μg/L of leptin,( 10.1 ± 5.7 ) ng/L of TNF-α and (35.1 ±6.5) mg/L of CRP in the GDM group were significantly higher than (21 ± 15) μg/L of leptin,(5.6 ± 3.0) ng/L of TNF-α,(30.5 ± 8.5) mg/L of CRP in control group.And leptin and TNF-α levels were positively correlated with HOMA-IR (r=0.372,0.494,all P <0.05).At day 42 of postpartum,the level of adiponectin in GDM group was negatively correlated with HOMA-IR ( r =- 0.299,P < 0.05 ),and the levels of leptin and TNF-α were positively correlated with HOMA-IR ( r =0.401,0.442,all P <0.05 ).Multiple linear regression analysis showed that the level of TNF-αt at day 3 and day 42 was most correlated with HOMA-IR ( r =0.363,0.274,all P < 0.05 ).( 3 ) ROC analysis of data from early pregnancy showed that the threshold for TNF-α to predict GDM was 5.45 ug/L.Conclusion TNF-ot might be the index to predict GDM and evaluate prognosis.
5.Fatal pulmonary embolism in the elderly with malignant tumor: a clinical pathological analysis of 19 autopsy cases
Baoyi LIU ; Zijin ZHANG ; Qing HE ; Baomin FANG
Chinese Journal of Geriatrics 2014;33(9):955-957
Objective To investigate the high risk factors,pathology and clinical features in fatal pulmonary embolism in the elderly patients with malignant tumor,and to analyze the characters of the embolus and provide experimental data for clinical prevention and treatment offatal pulmonary embolism.Methods Autopsy and clinical data of 19 malignancy cases with fatal pulmonary embolism admitted to Beijing Hospital from 1975 to 2006 were retrospectively analyzed.Results 33.9% of total pulmonary embolism were from malignant diseases (19/56).Saddle and massive pulmonary embolism were in 84.2% of total 19 cases,and micro-embolism cases were in only 15.8%.The 84.2% of embolisms were from pulmonary thromboembolism,15.8% from tumor emboli,and 5.26% from fungi emboli.Pulmonary adenocarcinoma was the most common (36.5%),the second was pancreatic cancer (15.8%).In all the clinical symptoms,78.9% of symptoms were dyspnea,15.8% were syncope.Tachycardia and cyanosis were the common physical signs.Conclusions Malignant tumor is an important risk factor for pulmonary embolism in elderly patients.There are various kinds of emboli in pulmonary embolism in elderly patients with malignant tumor.We should comprehensively consider the causes of pulmonary embolism and give the reasonable and effective treatment to the patients.
6.Clinical Study of Advanced Primary Hepatocellular Carcinoma Cells After TACE with use of Portal Vein Perfusion Chemothepary
Yamin LIU ; Dongmei JIANG ; Hong QING ; Xiaohong FANG ; Qingyong MA
Journal of Practical Radiology 1992;0(11):-
Objective To study the efficacy of transcatheter arterial chemoembolization (TACE )and continuous portal vein perfusion chemothepary (VPC) on advanced hepatocellular carcinoma cells (HCC). Methods The patients in group A (n=83) received the epirubicin (EPI) 40 mg and the cisplatin (CDDP) 80mg, lipiodol-anticancer drug emulsion was injected into the feeding arteries of tumors followed by embolization with gelatin sponge (GS) particles. Patients in group B (n=59) after receiving the same as the group A then VPC was carried out. Results The response rate ( CR + PR) in group A and B was 45.8% and 61.0%(P
7.Case of up-rushing gas syndrome and chest apoplexy.
Hong-Wei JI ; Qing-Zhang FENG ; Fang-Ming LIU
Chinese Acupuncture & Moxibustion 2013;33(10):904-904
Acupuncture Therapy
;
Chest Pain
;
therapy
;
Female
;
Humans
;
Middle Aged
;
Stroke
;
therapy
8.Value of acute physiology and chronic health state scoring in evaluation of severity of patients with organophosphorus poisoning.
Zhan-Fang WANG ; Jing-Tang HE ; Yu-Qing LIU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2008;26(7):434-435
APACHE
;
Adult
;
Female
;
Humans
;
Male
;
Organophosphate Poisoning
;
Young Adult
9.Influence of high dose progesterone on telomerase activity in patients with carcinoma of endome-trium
Jing-Xin CHENG ; Ting-Fang LI ; Qing LIU ; Al ET
China Oncology 2001;0(05):-
Purpose:To study the influence of treatment with high dose progesterone on telomerase activity in patients with endometrial adenocarcinoma.Methods:20 patients were treated for adenocarcinoma of endometrium with high dose progesterone and the change of telomerase activity in tumor tissue was examined by PCR-TRAP ELISA before and after treatment.Results:The average A value of tumor telomerase before and after treatment were 0.3636(0~1.11) and 0.1134 (0~0.556),respectively.It shows that telomerase activity in tumor was decreased by treatment with progesterone (P
10.Wide-detector Revolution CT with 70 kV tube voltage and prospective ECG-gated technique in diagnosis of congenital heart disease in infants and children
Fang ZENG ; Yunjing XUE ; Yuanfen LIU ; Zheting YANG ; Qing DUAN
Chinese Journal of Medical Imaging Technology 2017;33(4):594-598
Objective To investigate the value of wide-detector Revolution CTA with 70 kV tube voltage and prospective ECG-gated technique in diagnosis of congenital heart disease (CHD) in infants and children.Methods Forty-five infants and children with complicated CHD underwent echocardiography and wide-detector Revolution CTA.According to the sur gical findings,the diagnostic efficiency of Revolution CTA and echocardiography were calculated and compared.The radiation effective dose (ED) and iodine dose were calculated.The quality of CT images was also evaluated.Results There were 25 separate cardiovascular anomalies including 6 congenital cardiac structure anomalies and 19 congenital extracardiac vascular anomalies.For congenital extracardiac vascular anomalies,there was significant difference of diagnostic accuracy and the detectable rate between CTA (99.77% [853/855],97.73% [86/88]) and echocardiography (98.71% [844/855],88.64% [78/88];x2 =6.28,5.72,both P<0.05).The average of ED was (0.20±0.05)mSv and the mean iodine dose was (2.06± 1.09)g.All CT images were qualified for diagnosis.Conclusion The wide-detector Revolution CTA,with the prospective ECG-gated technique and 70 kV tube voltage,can provide high accuracy for assessment of CHD in infants and children,which can keep good image quality,with the low radiation dose.