1.Microcosmic Elements Study of H pylori-related Gastritis
Journal of Zhejiang Chinese Medical University 2014;(7):862-864
Objective To discuss the microcosmic elements and syndromes distribution of H pylori-related gastritis. [Method] Choose 100 cases, under gastroscope report, make statistics of frequency of disease nature elements and location elements, combine the nature and location for common syndromes. [Result] The H pylori-related gastritis has main disease location elements in stomach, esp. the sinuses ventriculi;the disease nature elements mainly concern hot, wet, sputum stasis, deficiency and blood stasis; the common syndromes: hot stomach, sputum and stasis blocking stomach, wet-hot accumulated in stomach, deficient stomach, wet stranding stomach and stasis blocking gastric col aterals. [Conclusion] Over the inconsistent syndromes in clinical H pylori-related gastritis, the microcosmic elements differentiation can further standardize syndromes and guide the treatment.
2.Analysis of ambulatory blood pressure levels and blood pressure variability in patients with type 2 dia-betes mellitus complicated hypertension
Chinese Journal of cardiovascular Rehabilitation Medicine 2016;25(6):591-594
Objective:To study influence of type 2 diabetes mellitus (T2DM) on ambulatory blood pressure (ABP) levels and blood pressure variability (BPV) in aged patients with essential hypertension (EH) .Methods:A total of 80 aged EH +T2DM patients treated in our hospital from Jun 2014 to Jan 2016 were selected as observation group ,another 80 aged pure EH patients were selected as EH control group .The 24hABP indexes and BPV indexes were compared between two groups . Results:Compared with EH control group , there were significant rise in 24h mean systolic blood pressure [24hSBP , (126.47 ± 9.64) mmHg vs .(134.98 ± 10.63) mmHg] ,nighttime mean SBP [nSBP ,(125.73 ± 10.19) mmHg vs .(133.74 ± 11.29) mmHg] ,daytime mean SBP [dSBP ,(128.29 ± 10.97) mmHg vs .(136.42 ± 12.18) mmHg] ,daytime mean pulse pressure [dPP ,(59.46 ± 10.79) mmHg vs .(65.38 ± 11.69) mmHg] ,nPP [ (58.00 ± 10.11) mmHg vs .(67.14 ± 9.93) mmHg] and 24hPP [ (59.27 ± 10.16) mmHg vs .(64.76 ± 11.62) mmHg] , P<0.01 all;and significant rise in 24hSBP standard deviation [24hSBPSD ,(12.63 ± 2.87) mmHg vs .(18.41 ± 3.09) mmHg] and nSBPSD [ (10.14 ± 3.53) mmHg vs .(14.89 ± 3.54) mmHg] in observation group , P<0.01 both .Conclusion:Diabetes mellitus elevates daytime and nighttime SBP ,increases BPV and risk of cardiovascular diseases in aged EH patients .
3.PRODUCTION AND CHARACTERISATION OF MONOCLONAL ANTIBODIES TO Francisella tularensis
Qing DUAN ; Zhongli ZHAO ; Qing TIAN ; Guozheng ZHANG
Chinese Journal of Zoonoses 2000;(2):3-4
Two Kinds of monoclonal antibodies (McAbs), Ft9 and Ft9t44, have been produced using the vaccine strain of Franciisela.tularensis as an antigen.The McAbs. Ft9 and Ft4,4, were isotyped to be IgG2b and IgM respectively Ft9 was found to be directed against outer membrane protein of F. tularensis, while Ft44 directed against lipopolysaccharide. The McAbs have been identified in detecting F. tularensis cells in an enzyme-linked immunosorbent assay. Ft9 was able to react with the bacterium in agglutination test and fluorescent antibody stain with no cross-reaction with other bacteria was found.
4.Color Doppler echocardiography study of interatrial communications in early infant
Mingjang ZHENG ; Yaping ZHAO ; Qing ZHANG
Chinese Journal of Ultrasonography 1999;8(3):148-150
Objective To explore the hemodynamics changes of patent foramen ovale (PFO) ofnewborn and early infant.Methods Two groups of cases were analyzed in the study.One group was 60 cases of left-to-right(L-R)shunt in fossa ovalis(FO),the other group was 31 cases of PFO that were foundduring corrective heart surgery but no shunts in FO detected by echocardiography.ACUSON 128 was used.The main indexes were mobility of FO valve,phase,direction,velocity of shunt in FO,jet width.Results ①Valve of FO moved from left to right and right to left with the change of cardiac-period;②44 cages appeared that the jet with<5 mm,Doppler spectrum was two-peaks, positive continuity,peak flow velocity <0.5 m/s;③1 6 cases appeared that the jet width>6 mm,postive wide spectrum,continued from latesystole to diastole,peak flow velocity>0.6 cm/s;④Inside diameter in surgery group was 2~6 mm,meanvalue was 3.4 mm.Conelusions FO valves appears two-directional shunt,the PFO of newborn and early infant mostly appears left-to-right shunt.Atrial septal defect could be diagnosed when the jet width>6 mmand peak flow velocity>0.6 m/s.
5.238U Radioactivity distribution in soils in the Beijing-Tianjin-Hebei Region
Qing ZHANG ; Ye ZHAO ; Cuihua XU
Chinese Journal of Radiological Medicine and Protection 2015;35(9):692-695
Objective To survey the 238U radioactivity level in the surface soil in the Beijing-Tianjin-Hebei Border (BTHB) region,and to prepare a high resolution distribution map of 238U activity concentrations.Methods The soil samples were collected in a grid (10 km × 10 km).The activity concentrations of 238U in soil samples were measured by using HPGe γ spectrometry.The distribution of the activity concentrations of 238U in soil samples was mapped by the aid of MAPGIS software.Results In total,416 samples were collected and measured.The activity concentrations of 238U were in the range of 0.1-106.0 Bq/kg,with an average of 34.7 Bq/kg.The 238U activity concentration distribution map showed that 238U activity concentration was in the range of 15-55 Bq/kg mostly on the surface soil in the BTHB region.Conclusions The map of 238U activity concentration shows the distribution of 238U activity concentration in the BTHB region.It is of importance to map the distribution of 238U activity concentration in the BTHB region,by converting a huge amount of data into the simple and intuitive graphics,and for evaluating the regional environmental radioactivity and studying the radioactive substance migration within the locality.
6.The TCM apprentice education mode in the application of standardized training of resident physicians
Wenshuo ZHAO ; Qing ZHANG ; Hao WANG
International Journal of Traditional Chinese Medicine 2015;(7):657-658
Resident standardization training system is established in the framework of modern western medicine. With less consideration to the specificity of TCM on the curriculum, teaching mode and other aspects, it is not suitable for the actual requirement of TCM hospital. TCM apprentice education has a long history, is an important form of the traditional education of Chinese medicine. Leading the TCM apprentice education mode into the standardized training of resident physicians, exploring the construction of the teaching model suited to help the masses of TCM college graduates training will play an increasingly important role in training work.
7.Serum levels of uric acid in the population of health check-up
Qing ZHANG ; Kun SONG ; Honglin ZHAO
Chinese Journal of General Practitioners 2010;09(8):569-571
Total 11 008 subjects underwent routine health check-up at Tianjin General Hospital in 2008. The results showed that the rate of hyperuricemia was 11.56% ( 1272/11 008 ) in this population, 17. 17% ( 1216/7082 ) for male, and 1.43% (56/3926) for female (P <0. 05). The serum uric acid levels were positively correlates with body mass index ( r = 0. 346), waist circumference ( r = 0. 449), systolic blood pressure ( r = 0. 193 ), diastolic blood pressure ( r = 0. 240), total cholesterol levels ( r = 0. 240) and triglyceride ester levels ( r = 0. 284 ). The factors including overweight, hypertension, hyperlipidemia and hyperglycosemia were clustered in subjects with hyperuricemia.
8.Curative effect analysis for patients with age related cataract and shallow anterior chamber after phacoemulsification
Qing-Yi, ZHAO ; Hong, SUN ; Yu, ZHANG
International Eye Science 2017;17(6):1099-1101
AIM: To study the curative effect for patients with age related cataract and shallow anterior chamber after phacoemulsification.METHODS: Totally 38 patients (38 eyes) with age related cataract and shallow anterior chamber were selected and divided into two groups according to the depth of the anterior chamber, as mild shallow anterior chamber group (2-2.5mm) 23 eyes, high risk shallow anterior chamber group (<2.0mm) 15 eyes.Thirty-eight patients (38 eyes) with age related cataract with normal anterior chamber were as control group at the same period.All the patients received the operations by the same doctor and were followed up for 3mo.The observed items included visual acuity before and after operations, intraocular pressure, anterior chamber depth, corneal endothelial cell density and complications.RESULTS: There were no significant difference on visual acuity, intraocular pressure and corneal endothelial cell density between the two groups before operations (P>0.05).The visual acuity improved significantly after operation in both groups (P<0.05).Intraocular pressure after operation decreased significantly in both groups (P<0.05).Anterior chamber depth increased significantly after operation in both groups (P<0.05).Corneal endothelial cell density decreased significantly in both groups (P<0.05).There were no significant difference on anterior chamber depth, intraocular pressure and corneal endothelial cell density between the two groups at different time point after operations (P>0.05).Posterior capsular rupture occurred in shallow anterior chamber group in 1 eye, suspensory ligament rupture in 1 eye.Posterior capsular rupture and suspensory ligament rupture occurred none in normal anterior chamber group.Postoperative corneal edema occurred in 10 eyes (26%) in shallow anterior chamber group, which occurred in 3 eyes (8%) in normal anterior chamber group.The difference on the incidence was significant (P <0.05).CONCLUSION: Phacoemulsification should be taken timely for patients with age related cataract and shallow anterior chamber.The postoperative visual acuity can be improved and the anterior chamber depth can increase.The operation is safe and effective for those patients.
9.Biosynthesis, Biotechnological Production and Applications of 5-Aminolevulinic acid
Jun-Qing WANG ; Zhao-Ming ZHANG ;
Microbiology 1992;0(03):-
Microbial production of 5-aminolevulinic acid (5-ALA) by photosynthetic bacteria compared to other bacteria and algae was reviewed. During anaerobic cultivation of the Rhodobacter spaeroides mutant strain, control of the redox potential was effective or producing large amounts of extracellular ALA. ALA has been practically applied in agriculture as herbicide, pesticide and growth-promoting factor for plants. New agriculture applications including salt tolerance and cold temperature tolerance of plants were also desired. Finally recent medical application for cancer treatment, tumor diagnosis and other clinical uses were discussed.
10.Dynamic change of PCT,hs-CRP and WBC count in neonatal infection and its clinical significance
Qiling ZHANG ; Qing ZHAO ; Shufen HUO
International Journal of Laboratory Medicine 2015;(24):3537-3540
Objective To investigate the dynamic change of procalcitonin (PCT ) and hypersensitive C‐reactive protein (hs‐CRP) in neonatal infection and its clinical significance .Methods 176 neonates with infection in our hospital from August 2013 to July 2014 were selected and treated by the routine therapy of anti‐infection ,oxygen inhalation ,etc .,and divided into the improvement group(89 cases) ,non‐change group(48 cases) and deterioration group(39 cases) according to the curative effect after 20 d therapy . Serum PCT and hs‐CRP levels were detected before treatment(T0) ,on 5 d(T1) ,10 d(T2) ,15 d(T3) and 20 d(T4) of treatment by adopting the enzyme linked immunosorbent assay(ELISA) .Results The PCT ,hs‐CRP levels and WBC count before treatment had no significant difference among 3 groups(P>0 .05);the PCT and hs‐CRP levels after treatment in the improvement group showed the significantly declining trend ,which reached the lowest at T4 (P<0 .05) ,while the PCT and hs‐CRP levels in the deterioration group showed the obviously rising trend ,which reached the highest at T4 (P<0 .05) ,but which in the non‐change group had no significant change (P>0 .05) .In terms of WBC count ,the WBC count in all the cases showed a rising first and then decreasing trend ,the WBC count at T4 in the improvement group was lower than before treatment(P<0 .05) ,while which in the deterioration group was higher than before treatment (P<0 .05) ,but which in the non‐change group had no significant change between before and after treatment(P>0 .05);the Spearman analysis results after treatment showed that the serum PCT ,hs‐CRP levels and WBC count were negatively correlated with efficacy (r1 = -0 .764 ,P1 <0 .05;r2 = -0 .724 ,P2 <0 .05 ;r3 = -0 .573 ,P3 <0 .05) .Conclu‐sion PCT and hs‐CRP can effectively reflect the therapeutic effect of neonatal infection ,and is closely correlated with the patient′s own immune status ,which can be taken as one of reference indicators for formulating the treatment scheme and evaluating progno‐sis ,and is worth for further clinical promotion .