1.The Practice of Dynamic Monitoring on Drug Use in Our Hospital
China Pharmacy 2007;0(32):-
OBJECTIVE:To promote the rational drug use in our hospital.METHODS:The in-patient and out-patient drug use in our hospital was monitored and analyzed.RESULTS:The income from pharmaceuticals accounted for 38% of the total income in our hospital and the drug use tend to be more rational after the practice of dynamic monitoring on drug use.CONCLUSION:Dynamic monitoring on drug use played a positive role on the rational use of drugs meanwhile it brings the proportion of drug consumption under effective control.
2.Determination of the Dissolution of Puerarin and 2,3,5,4'-tetrahydroxy-stibene-2-O-?-D-glycoside in Xinnaokang Capsules
China Pharmacy 2007;0(30):-
OBJECTIVE:To determine the dissolution of puerarin and 2,3,5,4'-tetrahydroxy-stibene-2-O-?-D-glycoside in Xinnaokang capsules.METHODS:The contents of puerarin and 2,3,5,4'-tetrahydroxy-stibene-2-O-?-D-glycoside were determined by HPLC and the dissolution rates of puerarin and 2,3,5,4'-tetrahydroxy-stibene-2-O-?-D-glycoside in Xinnaokang capsules were determined by basket-rolling method.RESUTLS:With water as releasing media,at a rotation rate of 100 r?min-1,the dissolution rate at 45 min was above 75% of the labeled amount.CONCLUSION:The method can be used for evaluation and control of the internal quality of Xinnaokang capsules.
4.Biomechanical Evaluation on Cervical spine stabilizing Effects of Cervical Interbody Spinal Fusion Using Allograft Fusion Cage
Junlin YANG ; Qingan ZHU ; Lilong CHEN
Chinese Journal of Orthopaedics 1996;0(09):-
Objective\ To evaluate the immediate effects and strength of allograft fusion cage(AFC) used for reconstructing stability of cervical spine. Methods\ Discs of C 5 and C 6 were resected on 8 fresh human cervical spine specimens, and autogenous iliac bone grafts(AIBG), and AFCs were implanted into the intervertebral spaces respectively. Compression test, pull out test and segmental motion measurement were studied.Results\ Comparing with intact and AIBG groups, the range of motions of C5-6 in AFC group were decreased in all directions except for extension; with (502?114) N compressive load,the vertebrae in AFC group were broken while the AFC were intact, but the AIBG were broken at (135?42) N load; with 300 N drawing load,no loosening was found between AFCs and vertebra, but it was found between AIBG and vertebra at 60 N load. Conclusion\ AFC could provide enough support,anti slide ability and could remain or increase the height of intervertebral spaces. It completely meets clinical and biomechanical requirements.
5.PGM1 genotyping by PCR-RFLP
Haiyan SONG ; Qingen YANG ; Hui CHEN
Chinese Journal of Forensic Medicine 1986;0(01):-
Objective The purpose of this paper is to study PGM1 genotyping by PCR RFLP.Method 300 unrelated individuals of Han were genotyped using PCR RFLP. The target amplificaton products of extron 4 and 8 of PGM1 gene were digested by Bgl II and Nla III respectively.The digested DNA fragments were typed by PAGE.Result This PGM1 RFLP system can discriminate 9 genotypes with Dp of 0 7450 in Han population.Compared with conventional PAGIEF, 1+2- and 1-2+ cant be differentiated and the rare genotypes also cant be detected by this method.The advantage of this method was PGM1 genotyping successfully in bloodstains stored for 25 years and with 0 1ng genomic DNA.PGM1 RFLP method is useful for forensic identification.
6.A Case-control Study about the Pain in the Patients with Protrusion of Lumbar Intervertebral Disc
Jing CHEN ; Qing WU ; Lei YANG
Journal of Chinese Physician 2001;0(08):-
Objective To assess the intensity of the pain and its negative impact on patients with protrusion of lumbar intervertebral disc (PLID) through using a case-control study. Methods 94 patients with PLID and 398 control individuals were enrolled in this study. The pains were assessed using McGill questionnaire. Results The sensory pain score(5.22?2.22), affective pain score (2.68?0.81)and VAS score (7.79?1.42)in the patient group were significantly higher than those in the control group (P
7.Operation time and curative effect on acute gallstone pancreatitis
Wei YANG ; Jiejing CHEN ; Qing NI
International Journal of Surgery 2016;43(6):371-374
Objective To analyse and summarise of the clinical effect and operative opportunity laparoscopic cholecystectomy for acute mild unobstructed gallstone pancreatitis.Methods Fify-four gallstone pancreatitis patients were treated as observation group in the first people's hospital of yangzhou from December 2012 to September 2015,which were treated with laparoscopic cholecystectomy after two weeks,while 53 patients which were treated with laparoscopic cholecystectomy after three months were treated as control group.The treatment effect,operation time,hospitalization time and total cost.Results There were no deaths,no bile duct injury and biliary fistula,the total hospitalization time [(19.8 ±2.6)d vs (26.5 ±3.5) d],the total cost [(2.6282 ± 0.2451) vs (3.2892 ± 0.3982)],recurrent pancreatitis rate (0) were lower than the control group(9.4%),the recovery rate of liver function were higher than the control group,there was significant difference between two groups(P < 0.05),however,there was no significant difference between two groups for postoperative complications and operation time (P > 0.05).Conclusions For acute mild unobstructed gallstone pancreatitis patients,the safe and feasible operative opportunity was recommended two weeks after the symptoms were completely improved,Laparoscopic cholecystectomy in the treatment of acute gallstone pancreatitis can promote recovery,shorten the hospitalization time.
8.Research progress on neuroendocrine prostate cancer induced by androgen depriva-tion therapy
Jun DU ; Qianqian CHEN ; Qing YANG
Chinese Journal of Clinical Oncology 2016;(2):86-88
Patients with metastatic prostate cancer are typically managed with androgen deprivation therapy. Most patients initially respond to treatment, but many eventually develop castration-resistant prostate cancer. Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of castration-resistant prostate cancer, which often results from neuroendocrine differentiation of prostate cancer cells. NEPC has a dismal outcome with an average survival of less than 1 year and exhibits less response to radiochemotherapy. At least 25%of patients with lethal castration-resistant prostate cancer are predicted to eventually develop this type of highly-aggres-sive NEPC. However, research on the molecular mechanism of NEPC is limited;thus, further studies are needed to explore the develop-ment and application of anticancer drugs for NEPC.
9.Effect of L-NAME on apoptosis in the gerbil hippocampus after recirculation following ischemia
Jingjun ZHANG ; Qing CHEN ; Mingfeng YANG
Chinese Pharmaceutical Journal 1999;(3):161-
OBJECTIVE:To observe effect of L-NAME on apoptosis in the gerbil hippocampus after recirculation following ischemia.METHOD:Bilateral occlusion of common carotid arteries and TUNEL stain methods in gerbitil hippocampal tissue slice were used.RESULTS:L-NAME inhibited apoptosis in the CA1 subfield.CONCLUSION:Endogenous NO mediated apoptosis is inhibited by the L-NAME.
10.Correlation of diabetes mellitus and endodontic interappointment pain
Guangyu YANG ; Shanglan QING ; Ying CHEN
Journal of Third Military Medical University 2003;0(10):-
9.0 mmol/L, and well controlled group if FPG0.05). However, in each group, the incidence rate of different algesic severity decreased with the increasing algesic severity. Conclusion EIP will occur in DM patients within a week after RCT. Well controlling of the blood glucose can reduce the incidence rate of EIP.