Authors have examined burned patient's plasma for detecting and estimating titres of endotoxin with micro-limulus test.It was shown that low and high titres of endo-loxin were usually found in burned palients infected with gram-negative bacteria,especially Ps.aeruginosa, and with high body temperature.In patients suffering from septi-semia caused by gram-negative bacteria were usually found higher titres of endotoxin, which would endanger patients lives. Patients who were dying with a higher litre of endotoxin had the symptoms of endotoxic shock, such as a fall of body temperature and blood pressure.The micro-limulus test is a rapid, sensitive, reliable and reagent-saving in vitro method for quantitative estimation of endotoxin. It is much useful for sndotoxaemia diagnosis and helps to expedite treatment and prognosis.

ObjectiveTo research the efficiency of literature-art-therapy (LAT) using in the phrase of rehabilitation in the inpatients with schizophrenia.Methods120 inpatients were randomly divided into two groups, the trial and the control, 60 patients respectively. The trial group was treated by LAT for 3 to 18 months, while both groups were routinely treated by neuroleptic. IPROS was used in assessment at the start and the end. ResultsThe degree of functional deficiency in trial group had significant decreased. The length of time used with rehabilitation therapy had correlated directly with improvement of social function. Conclusions LAT as an efficient way of rehabilitation therapy, had played a huge role in recovery of inpatients with schizophrenia.

Angioplasty, Balloon, Coronary ; methods ; Coronary Artery Bypass ; methods ; Coronary Vessels ; surgery ; Humans

BACKGROUND: Recent studies have demonstrated that esophageal stent is made of biodegradable materials and polymers,and satisfactory outcomes regarding its application in animal experiments have been made,but disputation exists. OBJECTIVE: To review the type,clinical application and related complications of esophageal stent. METHODS: Using esophageal stent,clinical application,complications in English and Chinese,manuscripts were retrieved by reading titles and abstracts. The manuscripts that are focused on the type,clinical application,and complications of esophageal stent as well as its application in malignant esophageal stenosis and the manuscripts that were recently published or in high-impact journals were selected. Finally,28 manuscripts were included. RESULTS AND CONCLUSIONS: Esophageal stent placement has become an important mean for esophageal carcinoma in patients who had no surgical conditions to relieve esophageal stenosis. With the development in technique,from initial membrane-free metallic stent,partial membrane-covered metallic stent to whole membrane-covered metallic stent,related esophageal diseases have been effectively solved,but the subsequent complications,such as gastrorrhagia and perforation,gastroesophageal reflux,and re-stenosis,have been not completely solved. Therefore,the therapeutic effects of different stents and the advantages and disadvantages of complications should be fully considered to reduce the complications to a largest extent and finally to improve patient's quality of life.

Objective:To evaluate the efficacy and safety of itraconazole in the treatment of fungal infection in the patients with hematological malignancies.Method:53 patients with malignant hematologic diseases were divided into three groups:empirical treatment group, suspected fungal infection group and established group.Itraconazole was given in a dose of 200mg twice daily in the first and the second days, from the third day in a dose of 200mg once daily.Response was established as normalization of temperature in the patients receiving itraconazole, and disappearance of clinical signs in the patients with suspected or established infection.Result:The 31 patients were eligible for efficacy evaluation for empirical treatment,and 25 responded to itraconazole(80.65%);of 9 established patients,6 responded to itraconazole(66.67%);of 13 suspected infection patients, 10 responded to itraconazole(76.92%).As to the side effects, there were no rigor and fever, but hepatotoxiciy were present in 5.66%, and no nephrotoxicity.Conclusion:Itraconazole is a highly effective drug with low side effects in treatment of fungal infections.But the hepatic and renal function tests must be carried out regularly when itraconazole infection is used.

Objective To examine the morphological changes in the cervical intervertebral foramen during axial rotation of cervical spine and explore its clinical significance for the diagnosis and treatment of cervical degenerative disease. Methods Ten healthy volunteers (5 male, 5 female) were subjected to transectional scan by multislice spiral computed tomography of cervical spine from the upper edge of C 3 vertebra to the lower edge of C 7 vertebra. On the 45 degree oblique reconstructions of C 3～4, C 4～5, C 5～6 and C 6～7 intervertebral foramina, four parameters were measured, including foraminal height, foraminal width (both superior and inferior), and cross-sectional area of the foramen. Statistic analyses were performed to examine the morphological changes in the cervical intervertebral foramen. Results It was found that the foraminal cross-sectional area was decreased on the side of rotation,and increased on the opposite side of rotation. Significant correlation was revealed between the variation rate of the C 3～4 intervertebral foramen cross-sectional area and the rotational degree between C 3 and C 4. Conclusion Morphologic changes were found in the cervical intervertebral foramen due to axial rotation. The correlation between the cross-sectional foraminal areas with the degrees of rotation of the vertebrae was statistically significant. The results of the test have the clinical significance on the prevention, diagnosis and treatment of the cervical degenerative diseases, especially of the radiculopathy.

Objective The effect of hepatic partial resection for hepatic trauma.Methods Thirty-Six patients with hepatic trauma were operated on the bases of litertures,we elucidated the indication and method of operation and prevention of operative complications .Resuts Three cases died,a death rate of 8 33%,and a cure rate of 91 8%.Conclusion Hepatic partial resection is an effective method for treatment of hepatic trauma.

Objective:To study the feasibility and reliability of using phosphorylated H2AX(?H2AX)as a predictor for sensitivity of hepatic carcinoma cell HepG2.215 to chemotherapy agents: etoposide, doxorubicin, mitomycin, and cisplatin. Methods: HepG2.215 cells were exposed to etoposide, doxorubicin, mitomycin or cisplatin of 1, 2, 4 and 20 concentration index (CI). Untreated HepG2.215 cells were taken as control. The proportion of HepG2.215 cells expressing ?H2AX was measured by flow cytometry, the number of ?H2AX foci in HepG2.215 cells was measured by immunocytochemistry, and cell proliferation was measured by MTT. The correlation between the number of ?H2AX foci and the percentage of HepG2.215 cells expressing ?H2AX in HepG2.215 cells was analyzed; the correlation of CI with the percentage of HepG2.215 cells expressing ?H2AX or ?H2AX foci and inhibitory rate of cell proliferation was analyzed; and the correlation of inhibitory rate of cell praliferation with the percentage of HepG2.215 cells expressing ?H2AX or ?H2AX foci was also analyzed. Results: There was a positive correlation between the number of ?H2AX foci and the percentage of HepG2.215 cells expressing ?H2AX in HepG2.215 cells after treatment with the above 4 agents (all P

Objective To investigate and analyze the relative factors in elderly men with type 2 diabetes mellitus(T2DM)complicated with osteoporosis(OP),thus to provide guidance for prevention of OP complicated with T2DM in elderly men.Methods Dual X -ray absorptiometry determination of bone mineral density (BMD)of 67 cases of elderly men with diabetes,men were divided into OP group (n =32),NOP group (n =35).Then,we compared differences in body mass index(BMI),diabetes duration,fasting plasma glucose (FPG),glycosylated hemo-globin(HbA1c),patients'age,fasting insulin(FINS),insulin sensitivity index(ISI),quantitative of urinary albumin (ALb),quantitative of urinary protein in 24 hours and alkaliphosphatase level(ALP),low density lipoprotein choles-terin(LDL -C),triglyceride(TG),and made correlation analysis.Results Compared with those in NOP group,pa-tients in OP group had older age,longer disease course,smaller baric index,lower BMD,higher ALP,lower FINS,low-er ISI,higher HbA1c,higher quantitative of urinary protein in 24 hours and urinary albumin,higher LDL -C,which were significantly different (P <0.05);BMD of elderly men with T2DM was negatively correlated to patients'age, disease course,HbA1c,quantitative of urinary protein in 24 hours,ALb,ALP and LDL -C,but positively correlated to BMI,FINS and ISI.Conclusion Many factors,such as elderly,low body weight,long duration of the disease,high level of blood sugar,insulin dysfunction,low insulin sensitivity,high level of blood suger,insulin dysfunction,low insulin sensitivity,high serum alkalinephosphatase,high LDL -C and diabetic nephropathy,contribute to osteoporosis in elderly men with T2DM.

China ; Heart Defects, Congenital ; therapy ; Humans