Objective To explore the role of Clara cell secretory protein(CCSP) in asthmatic children and compare the levels of CCSP in sera and induced sputum.Methods Thirty-four children with asthma who were in remission and 25 healthy controls were enrolled.Sera and hypertonic saline-induced sputum were obtained in asthmatic children,and sera alone were obtained in control subjects.The le-(vels) of CCSP were measured in sera and induced sputum by enzyme linked immunosorbent assay.Results Asthmatic children,compared with controls,had significantly lower concentration of CCSP in sera(P

Objective To observe the influence of long-term treatment with inhaled corticosteroid on biochemical bone indexes and bone mineral density (BMD) in children with asthma. Methods The design was a randomized, paralleled group study with 3 low dose regiments of 100, 200,300 micrograms of budesonide per day in 45 children with asthma aged 5-8 years old for 12 months. Before inhaled corticosteroid therapy and 6th,12th month,clinical effects were observed and lung function(FEV1) was measured; concentration of serum osteocalcin(OST),insulin-like growth factor-1(IGF-1),bony alkaline phosphatase (BALP) and urinary deoxypyridinolin: creatinine (DPD/Cr) were measured; BMD was examined by dual energy X-ray absorptiometry. Results Clinical evaluation was improved and there was significant increase in FEV1 of asthmatic children. The amount of serum OST was slightly higher,yet no significant compared with that of normal control group. There was significant increase of serum BALP in asthmatic children after treatment; there was significant increase in serum IGF-1 of patients group after treatment compared with in normal children at the same age group; there was significant decrease in urinary DPD/Cr after treatment.There was no significant decrease in BMD before and after treatment at the hip (neck of femur , trochanter of femur ,Ward′s triangle),the lumber area of the spine (L2-4) and forearm (ultradis, distal). Conclusion Long-term treatment with low does corticosteroid dose not restrictedly affect bone metabolism and BMD in children with asthma.

OBJECTIVETo summarize the clinical management of abdominal compartment syndrome (ACS) in burn patients with severe burn injury.

METHODSTwelve serious burn patients with abdominal compartment syndrome hospitalized in our center from January 2001 to April 2005 were enrolled in the study. Among them 3 patients were treated with conservative method, 4 with escharectomy of abdominal wall, 5 with laparotomy for decompression. The clinical results were analyzed statistically. Bladder pressure, central venous pressure, systolic blood pressure and arterial blood oxygen partial pressure (PaO2 ) were measured and compared before and after operation.

RESULTSAmong these 12 patients, 5 died with the overall mortality of 41.67%. But only 3 died among 9 patients undergone operation. Most of patients were oliguric,with abnormal bladder pressure, central venous pressure, and systolic blood pressure 24 hours before operation. But these parameters were significantly improved after operation ( P <0. 01).

CONCLUSIONEarly abdominal escharectomy and timely abdominal decompression are vital for the management of ACS in burn patients.

Abdomen ; pathology ; Adult ; Aged ; Burns ; complications ; therapy ; Compartment Syndromes ; etiology ; surgery ; Female ; Humans ; Male ; Middle Aged

OBJECTIVETo evaluate the efficacy and safety of modified FOLFIRI regimen in advanced colorectal cancer (CRC) patients refractory to fluoropyrimidine and oxaliplatin.

METHODSThe modified FOLFIRI regimen consisted of intravenous infusion of irinotecan 180 mg/m2 d1 + LV 200 mg/m2 dl + 5-Fu 400 mg/m2 bolus dl plus 46-hour intravenous infusion of 5-Fu 2.4 g/m2, every 2 weeks as one cycle. The main selection criterion for this study was the advanced CRC refractory to fluoropyrimidine and oxaliplatin.

RESULTSOf the 80 evaluable patients for efficacy: 10 (12.5%) had a partial response, 51 (63.7%) stable disease, and 19 (23.8%) progressive disease. The median time to progression was 96 days. Safety analysis was based on the data of 83 evaluable patients. The most frequently observed grade 3 or 4 toxicities were neutropenia (24.1%), nausea/vomiting (8.4%), and diarrhea (2.4%).

CONCLUSIONModified FOLFIRI regimen is effective and well tolerated in patients with advanced colorectal cancer refractory to fluoropyrimidine and oxaliplatin.

Adult ; Aged ; Antineoplastic Agents ; therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; adverse effects ; therapeutic use ; Camptothecin ; adverse effects ; analogs & derivatives ; therapeutic use ; Colonic Neoplasms ; drug therapy ; pathology ; Diarrhea ; chemically induced ; Female ; Fluorouracil ; adverse effects ; therapeutic use ; Humans ; Leucovorin ; adverse effects ; therapeutic use ; Male ; Middle Aged ; Nausea ; chemically induced ; Neoplasm Staging ; Neutropenia ; chemically induced ; Organoplatinum Compounds ; therapeutic use ; Prospective Studies ; Pyrimidines ; therapeutic use ; Rectal Neoplasms ; drug therapy ; pathology ; Remission Induction ; Treatment Failure

Unlike other non-gynecologic solid tumors, such as breast cancer, lung cancer, metastasis to bone from endometrial carcinoma is rare, metastasis to extremity is extremely rare. We report a 51-year-old multiparous woman with FIGO Stage IVb Grade 2 endometrial adenocarcinoma which metastasized to left lower extremity bone. She received an amputation of left lower extremity below the knees, and a total abdominal hysterectomy and bilateral salpingo-oophorectomy, and followed by systemic chemotherapy, radiation therapy to the pelvis and progestational agent. She had a complete response to above treatments, and disease-free survival for 10 months. After recurrence, she received chemotherapy, radiotherapy and progestational agent once again. She had lived 56 months and is still alive by the time of report. Metastasis of endometrial carcinoma to extremity bone can rarely occur and should be considered when the patient with endometrial carcinoma complained of unexplained pain and swelling associated with extremity bone.
Bone Neoplasms ; pathology ; secondary ; surgery ; Endometrial Neoplasms ; complications ; pathology ; surgery ; Female ; Humans ; Middle Aged

Adult ; Female ; Humans ; Hysterectomy ; Leiomyoma ; diagnosis ; Middle Aged ; Muscle Neoplasms ; complications ; surgery ; Uterine Neoplasms ; complications ; surgery

OBJECTIVETo investigate the validity of hepatic resection as a treatment option for hepatic parenchymal metastasis in patients with recurrent epithelial ovarian cancer.

METHODSA retrospective review of the clinicopathological and follow up data of 39 patients treated in our hospital from 1996 to 2008 was conducted.

RESULTSTen patients underwent partial hepatic resection for metastatic ovarian cancer. All the 10 patients underwent surgery were with unilobar metastasis and the number of tumors was lower than 3(P < 0.05). No significant difference existed in patient age, the primary pathology type and tumor grade, the rate of optimal primary cytoreductive surgery, the disease free survival after the primary therapy and the serum CA125 level at the liver metastasis when compared with the 29 patients accepted salvage chemotherapy (P > 0.05). There were 7 patients who achieved optional surgery. The operation complication was 3/10 and there was no perioperative mortality. There were 2 patients without postoperative chemotherapy in the 8 recurrent patients with microscopic negative margins. The median recurrence time was 12 (5 - 24) months after the hepatic resection. The overall median survival periods after hepatic metastasis were 26 and 9 months and the 3-years cumulative survival rates were 60.0% and 16.8% for the optimal surgery patients including hepatic surgery and the salvage chemotherapy patients, respectively (P < 0.05).

CONCLUSIONHepatic resection for liver metastatic epithelial ovarian cancer is safe and may achieve long-term survival in patients after optimal second cytoreductive surgery.

CA-125 Antigen ; blood ; Disease-Free Survival ; Female ; Humans ; Liver Neoplasms ; pathology ; secondary ; surgery ; Neoplasm Recurrence, Local ; pathology ; Neoplasms, Glandular and Epithelial ; pathology ; Neoplasms, Second Primary ; Ovarian Neoplasms ; pathology ; Retrospective Studies ; Salvage Therapy

Objective:To investigate the sleep status of elderly hypertensive patients stratified into the group of high risk or above in a community.Methods:1 606 patients aged over 65 years were selected from the hypertension database of Gumei Community Health Service Center, Minhang District, Shanghai, including 757 males and 849 females.Pittsburgh Sleep Quality Index (PSQI) was used to investigate the population.Results:43.2% of the patients had sleep disorders.The PSQI score was 7.09±2.95 in the males and 8.07±3.39 in the females (P<0.05).In terms of age, the prevalence of sleep disorders among the group of 65 to 69 years, the group of 70 to 74 years and the group of older than 75 years was 40.1%, 42.6%, and 49.4%, respectively.The percentage of sleep disorders in patients with diabetes and those without diabetes was 45.4% and 42.3% (P<0.05).In characterizing the sleep disorder, 51.2% of the patients had difficulty falling asleep frequently, 54.8 % of them spent more than six hours in bed but most of these patients (over 95%) had a low sleep efficiency, staying awake about one third (35%) of the time in bed.In the treatment of sleep disorders, less than one-third of the patients took sleeping pills, and about 13% of them took sleeping pills regularly.In evaluation of the impact of sleep disorders, nearly 40% of the patients had daytime dysfunction.Conclusions:Among the elderly hypertensive patients stratified into the group of high risk or above, sleep disorders are common.Female, advanced age and diabetes are risk factors to sleep disorders.Which should be paid attention to health workers.

Objective To explore the gene polymorphisms of ApoAⅠ-75 Msp1,ApoB Msp1,ApoCⅢSst1,LRP5,and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers.Methods The patients are divided into 9 groups.There were a total of 720 cases,80 patients in each group,The patients was carried out by SnaPshot method (single-base multilocus micro-sequencing),and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results. Results There was association between gene polymorphisms of ApoAⅠ-75Msp1 and ApoE and different modes of two pairs of semi-hepatitis B ( P ＜ 0.05 ),while there wasn't any association between gene polymorphisms of ApoB-Msp1,ApoCⅢ-Sst1, LRP5 and different modes of two pairs of semi-hepatitis B (P ＞ 0.05 ).Conclusion The gene polymorphism of ApoAⅠ-75Msp1 and ApoE was associated with the different modes of HBV markers.

OBJECTIVE To explore the correlation between polymorphisms in the toll-like receptor 4 (rs1 927914, rs10759932 and rs1 1 536889) and susceptivity,gene expression,cytokines and blood lipid metabolism in southern Han Chinese with stroke due to wind-phlegm obstruction,qi deficiency and blood stasis.METHODS 559 stroke cases were divided into two groups based on case-control study method,with 248 cases in the qi deficiency and blood stasis group,31 1 cases in wind-phlegm obstruction group.In addition,another 605 cases were involved as the healthy control group with the corresponding gender and age.All the subjects were from the Han nationality.Sequenom MassARRAY technology was adopted for testing and genotyping of rs1 927914,rs10759932 and rs1 1 536889 in the toll-like receptor 4.Real-time fluorescence quantification (qPCR) was applied for examine mRNA expression.Enzyme linked immunosorbent assay(ELISA)was used to detect the level of interleukin-1β(IL-1β),interleukin-6 (IL-6),interleukin-8 (IL-8),interleukin-12(IL-12) and tumor necrosis factor-α(TNF-α).HITACHI 7600 automatic biochemical analyzer was applied to test the total cholesterol(TC),triglyceride(TG),high den-sity lipoprotein cholesterol(HDL) and low density lipoprotein cholesterol(LDL).RESULTS There existed a statistical differ-ence between the male cases of the qi deficiency and blood stasis group and male cases of the control group in the distribution of gene frequency of rs10759932(P <0.05).The locus polymorphism of both rs1 927914 (dominant model:OR =0.65,95%CI=0.43-0.96,Padj =0.031) and rs10759932 (dominant model:OR =0.64,95%CI =0.41 -0.99,Padj =0.046) were closely related with susceptivity of stroke male of qi deficiency and blood stasis type.The IL-8 level of male stroke patients of qi deficiency and blood stasis type with the rs10759932 TT genotype was much lower than those with CC+CT(P <0.01). Rs1 1 536889 polymorphism was notablely related to TG level(additive model:Padj =0.021,dominant model:Padj =0.013) and HDL level(dominant model:Padj = 0.032) in stroke patients of qi deficiency and blood stasis type.CONCLUSION TLR4 polymorphisms exert certain influence on the occurance of stroke due to qi deficiency and blood stasis in Han Chinese men and they have been involved in the inflammatory reaction and blood lipid metabolism.