Biomarkers ; Carcinogens ; Epigenesis, Genetic ; Humans

Gynecological malignancies have seriously affected women′s living quality and survival.In recent years,studies have shown that androgen is closely related to the occurrence and development of gynecologic malignancies.In this paper,we mainly discussed the mechanism of androgen on gynecologic malignancies.

Objective Toexplorethepatencyofbridgevesselsinpatientsaftercoronaryarterytransplantation,andto providereferencefortheselectionofclinicalbridgevessels.Methods Dataof32patientsunderwentcoronaryangiography aftercoronaryarterybypassgraftingwereselectedandanalyzedretrospectively.Theoverallusageandpatencyofthegreat saphenousveingraft(SVG),theleftinternalmammaryartery(LIMA)andtheradialartery(RA)wereanalyzed.Thepatency ofthenearfuture(5years),themediumterm(5-10years)andlongterm(>10years)werecomparedbetweenthethreekinds ofbridgingvascularvessels.TheRAocclusionwasanalyzed. Results Thetotalnumberofbridgevesselsusedin 32 patientswas85,only1caseusedrightinternalmammaryartery(RIMA),theothersusedSVG,LIMAandRA,inwhich48, 23and13brancheswereusedrespectively.ThepatencyratesofSVG,LIMAandRAwere25%(12/48),73.91%(17/23)and 69.23(9/13)respectively.Therecentandmedium-termpatencyratesofallbridgevesselsshowedadecreasingtrend,in whichtherecentpatencyrateofSVGwassignificantlyhigherthanthatinLIMA,theintermediatepatencyratesofLIMAand SVGwerehigherthanthatofRA,andthelong-termpatencyrateofRAwassignificantlyhigherthanthatofLIMAandSVG. Therewasseverestenosis(＞90%)orocclusionintheproximalsegmentofanastomosisinthe9radialarteriesunobstructed. Conclusion TheutilizationrateofRAisstilllow,andtheoverallpatencyrateofRAissuperiortotheSVG.RAcanbe usedasthesecondoptimalbridgevessel.ThepatientselectionandRAevaluationshouldbedonebeforeapplyingRA.The proximalstenosisdegreeoftargetvesselsignificantlyaffectsthelong-termpatencyofRA.

Objective To inverstigate the CT findings of non-Hodgkin’s lymphomas in orbit and paranasal sinuses,nasal cavity.Methods 12 patients with non-Hodgkin’s lymphomas in orb it and paranasal sinuses,nasal cavity diagnosed pathology retrospectivly were an alyzed based on their CT data. Results 12 cases of all were non-Hodgin’s lymphoma.Ther e were lymphoma of orbit in 8 cases, lymphoma of maxillary sinus in 3 cases, lym phoma of nasal in 1 case .There was eyelid tumor in 3 cases, soft tissue tumefac tion in adjacent eyelid in 2 cases,soft tissue tumefaction in adjacent maxillary region of nose back in 3 cases and local bone absorption in 2 cases.Conclusion Tumors in orbit and maxillary sinus nasal cavi ty were not concomitant with bone destruction. The sicken tumefaction or tumors formed in adjacent eyelid and maxillay region of nose back are important clue of lymphoma.

Child ; Erdheim-Chester Disease ; Female ; Humans

Objective To study whether the mechanism of mifepristone in treating adenomyosis is suppressing matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1(MMP-9/TIMP-1). Methods Thirty-five patients in the mifepristone treated group(19 cases of adenomyosis) and the control group(16 cases of adenomyosis,non-drug treated) underwent hysterectomy.Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium.Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Results The ectopic endometrium of the mifepristone treated group expressed lower level of MMP-9,higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group(P

OBJECTIVETo explore the effect of auricular point sticking before operation for postoperative complications of external excision and internal ligation on mixed hemorrhoid.

METHODSEighty patients with mixed hemorrhoid were randomly divided into an observation group and a control group, 40 cases in each group. In the control group, paracetamol and dihydrocodeine tartrate tablets were applied with oral administration 1 h after operation, 510 mg each time, twice a day; at the same time, diosmin tablets were treated with oral administration, 0.9 g each time, twice a day. Three days' treatments were required successively. In the observation group, auricular point sticking was used before operation based on the treatment in the control group. The auricular points of Shen (Co10), Pangguang (CO9), Shenmen (TF4), Pizhixia (AT4), Jiaogan (AH6a) and Gangmen (HX5) were selected. The patients were asked to press the points 3-6 times per day, 3-5 min each time, 3 days' treatment in total. The scores of the postoperative complications in the 1st and the 2nd days were compared between the two groups such as pain, edema, hematochezia, retention of urine, etc.

RESULTSAfter operation, the scores of pain, edema, hematochezia, retention of urine in the 2nd day were all decreased obviously than those in the 1st day in the two groups (all P<0.05); and the scores of pain, edema, hematochezia, retention of urine in the 1st and the 2nd days of the observation group were lower than those in the control group (all P<0.05).

CONCLUSIONAuricular point sticking before operation combined with conventional western medicine with oral administration for preventing and treating postoperative complications of external excision and internal ligation on mixed hemorrhoid achieves positive and reliable efficacy.

Acetaminophen ; administration & dosage ; Acupuncture Points ; Acupuncture, Ear ; Adult ; Codeine ; administration & dosage ; analogs & derivatives ; Combined Modality Therapy ; Female ; Hemorrhoids ; surgery ; Humans ; Ligation ; Male ; Middle Aged ; Postoperative Complications ; drug therapy ; prevention & control ; therapy

Anthrax ; Humans ; Occupational Diseases ; microbiology

Brucellosis ; Humans ; Occupational Diseases ; microbiology

OBJECTIVE:To determine the plasma concentration of mycophenolic acid (MPA) in renal transplantation patients by HPLC-Fluoremetry. METHODS: The sample was subjected to precipitation of proteins using 5% Zinc Sulfate methanol saturated solution,and the supernatant (20 ?L) was taken for sample injection and determination on Zorbax Eclipse XDB C18 with mobile phase consisted of acetonitrile-methanol-0.2 mol?L-1 glycine buffer(18∶2∶80,pH=9.0) at a flow rate of 1.0 mL?min-1. The column temperature was of 25℃;the excitation wavelength(EX) was 342 nm and the emission wavelength(EM) was 425 nm. RESULTS: The linear range of MPA was 0.5～40 mg?L-1,with its lowest limit of quantitation at 0.5 mg?L-1. The methodology recovery was 98.23%～101.00%;the extraction recovery of MPA was 91.56%～94.46%;the intra-day RSD was 0.64%～3.22% and the inter-day RSD was 5.12%～6.10%. CONCLUSION: The method is sensitive,rapid,accurate,convenient,and applicable for the quantitative determination of plasma concentration of MPA in renal transplantation patients.