Objective:To study the clinical characteristics of retinoblastoma in children.Methods:To analyze the age,sexuality,symptom,the accompaniment of symptom and the diagnostic feature of 53 retinoblastoma cases.Results:The average diagnostic age was two years and three months.There was no obvious sex difference.The principal first symptom of 24 cases was leukocoria,11 cases was strabismus,8 cases was big cornea or muddy cornea,6 cases was exophthalmos,1 case was nystagmus,2 cases was anterior chamber bleeding,and 1 case with health examination.It was significantly higher in single eye(85%) than in both eyes(15%).Conclusion:More and more people recognize the importance of eye health care,and the average diagnostic age becomes younger.The principal first symptom remains "galeamaurosis".The clinical characteristics of retinoblastoma in children are diversified?concealed?puzzling and easy to make missed diagnosis.

Specific fusion genes of leukemia are currently the main biomakers for minimal residual disease (MRD)monitoring. Recent studys have found that the WT1, PRAME, ERG genes may be the potential acute leukemia related molecules, and can be used to monitor acute myeloid leukemia's MRD, directing clinical stratified therapy and estimating prognosis. This article reviews the pathogenesis, incidence of these genes and the relationship to the clinical prognosis.

Objective To discuss the influence of systematic nursing on cancer related fatigue and life quality of patients with breast cancer during perioperative period.Methods 197 patients in our hospital with breast cancer were randomly divided into the experimental group (99 cases)and the control group (98 cases)from November 2010 to December 2011.The experimental group was given systematic nursing method and the control group received traditional nursing.After treatment,the influence of nursing intervention on cancer related fatigue and QOL were compared between two groups.Results The score of QOL was(92.1±1.6)after nursing in the experimental group,higher than before systematic nursing and the control group.The severity of cancer related fatigue in the experimental group was apparently lower than before nursing intervention and that in the control group.There was significant difference.Conclusions The systematic nursing can reduce the level of perioperative cancer related fatigue and improve the life quality for the patients with breast cancer,so it can be widely used in clinic.

Thioredoxin(TRx) is a kind of endogenous protein which widely distributes in prokaryotic and eukaryotic cells.It possesses two vicinal cysteine residues at the active site and therefore can provide strong reducing activity and catalyze the reduction of protein-protein disulfides effectively.In addition,TRx plays a vital role in regulating intracellular redox homeostasis.Recent studies showed that TRx is muhifunctional and has a protective effect on the occurrence and development of a variety of human diseases including ocular diseases,such as age-related cataract,choroidal neovascularization,retinal diseases and optic nerve diseases,etc..Many researchers assessed the protective effect of TRx on ocular diseases in recent years.The progress in the relationship of TRx with eye diseases was reviewed in this article.

Idiopathic thrombocytopenic purpura(ITP),which is the most common acquired hemorrhagic disease in childhood period,is also called immune thrombocytopenia because it is an immune-mediated disorder characterized by isolated thrombocytopehia.In recent years,the diagnosis and treatment of ITP has been dramatically improved,and some consensuses concerning the staging,symptom scoring,treatment indications and prognosis have been achieved.This article reviews the pathogenesis,epidemiology,symptom scoring,staging,grading of severity,treatment and prognosis evaluation of ITP in children.

Based on the main body's definition of philosophy,the article points out that patients are the main body of clinic activities.It also analyzes patients'main status in the performance of clinic activities and in the medical countermeasure.The concluson is that a harmonious relationship between doctors and patients should be composed from bi-main bodies characteristic of the clinic activities.

The expansion of high-containment bio-defense laboratory in USA is introduced in such aspects as the increase of laboratory magnitude,amplification of laboratory area and the funding growth of the United States National Institutes of Health(NIH).In addition,a series of problems caused by the expansion are analyzed in the perspective of the biosafety training,information exchange of laboratory and public participation.

Objective To explore the clinical effiicacy and effect on cytokines of invigorating the kidney and activating blood fomula on treating osteoarthritis patients in the pattern of kidney deficiency. Methods 113 patients with knee osteoarthritis were randomly divided into two groups including 56 cases of treatment group and 57 cases of control group, which were treated by invigorating the kidney and activating blood fomula and combinaton of Celecoxib and Glucosamine respectively. The clinical effiicacy of two groups were investigated by Womac osteoarthritis index and the average severity of OA index. The changes of serum inflammatory cytokines TNF-? and IL-6 were detected by ELISA. Results The total efficiency of the treatment group was 89.3% and better than the control group (P 0.05) compared with control group. The serum TNF-?, IL-6 levels of treatment group significantly decreased after treatment in treatment group (P

Set up observation group and control one,observe electro-acupuncture's effect on Fluoxetine side effect during treatment of depression.The result shows electro-acupuncture has improvement on side effect of Fluoxetine,which is more marked with long medication.

Objective To develop a method to determine molybdenum in radix puerariae and the soil. Methods A method for determination of trace molybdenum in radix puerariae and the soil where it growth by single sweep polarography has been used. Results The linear range was 0.010-1.0 ?g/ml, r=0.999 0, the detection limit was 6.0?10-3 ?g/ml, the recovery rates were 98.0%～106.0%, RSD was 2.2%-4.8%. Conclusion This method is suitable for the determination of molybdenum in radix puerariae and the soil. The content of Mo in radix puerariae is related to that in the soil.