As a new radiotherapy for carcinomas, Proton Therapy has been making progresses. Compared with conventional radiation, proton has a better physical characteristic and a similar biological effect. Proton Therapy consists of Conformal Proton Radiotherapy, Intensity-Modulated Proton Therapy, Stereotactic Radiotherapy, Proton Scanning Radiation and et al. With the utilization of Bragg peak, Proton therapy can increase the dose of carcinoma region and reduce the dose of normal tissue, and thus it has a good curative effect and can be a good cure for many indications. In spite of the above-mentioned, Proton therapy has to be improved in the future.

ObjectiveTo overview the relationship between translational medicine and Chinese medicine, and the developments of translational medicine in TCM. MethodsResearch and reporting literatures on translational medicine m TCM and western medicine were collated and analyzed. The development and application of translational medicine was introduced. ResultsTranslational medicine has been successfully introduced into the realm of TCM applications and researches. ConclusionThe rise of translational medicine will promote the development of Chinese medicine and provide better opportunities for innovation.

This paper discussed key factors and significations of development and construction of professional traditional Chinese medical library alliance. The targets of establishing the alliance is to provide on-line cooperative catalogue, documents exchange and OPAC (online public access catalog), the prescription of the alliance construction, and the latest trend of the alliance. The paper also explored the policy for constructing library alliaqce and put forward the developing treads of this alliance.

The establishment of overseas traditional Chinese medical book database provides a new approach to help Chinese medical researchers to catch on the overseas Chinese medicine development. Overseas traditional Chinese medical book database is introduced and the overseas development of Chinese medicine has been discussed by using statistic results from the database in this paper.

Objective To analyze the clinical data,radiological and pathological features of breast cancer which were understated by image,and summarize the causes.Methods The clinical features,radiological features and pathological data of 26 cases of breast cancer were retrospectively analyzed.The preoperative ultrasound and mammography BI-RADS grades of these 26 cases were both ≤ 3,and they were confirmed to be breast cancer by pathology.The clinical and pathological data of 1224 cases of breast cancer in the same period were compared.Results For the 26 cases,100％ were early breast cancer,100％ were HER2 negative breast cancer,and only 1 case had lymph node metastasis.26％ were special type of breast cancer.Mammography showed glandular multi type,and ultrasound showed atypical or typical benign features.Conclusions Breast cancer understated by image shows features of young age,early stage,well differentiated,low malignant degree,not easy to be visualized by mammography,and their ultrasound features are usually atypical.In clinical setting,analysis of the ultrasound and mammography images should be combined with other examination,to decrease misdiagnosis rate.

Objective: To analyze the correlation of carotid artery color Doppler flow imaging (CDFI) indices and transcranial Doppler ultrasound (TCD) indices. Methods: The clinical data of 118 hospitalized patients with ischemic cerebrovascular diseases were included in the present study and all of them received CDFI and TCD examination. The patients were divided into two groups according to presence of carotid plaque group; t-test was used to identify the correlation between the presence of carotid plaque and TCD indices. Meanwhile, the patients were also divided into three groups according to the quantity/distribution of plaque) one-way ANOVA(F-test) and student-Newman-Keuls were used to identify the correlation of the quantity/distribution of plaque with TCD indices. The patients with carotid plaque were divided into three groups according to the plaque texture) one-way ANOVA(F-test) and student-Newman-Keuls were used to identify the correlation of the quality of plaque with TCD indices. Meanwhile, linear correlation was used to identify the correlation of the common carotid intimal-medial thickness (CCA IMT) with TCD indices. Results: The resistance index (RI), pulsatile index (PI) and ratio of peak systolic to least diastolic flow velocity (S/D) of bilateral middle cerebral arteries and basal artery in patients with carotid plaque were significantly higher than those in patients without carotid plaque (P<0.05); other TCD indices including Vp, Vd, and Vm were not significantly different. The quantity/distribution of plaque, the quality of plaque and CCA IMT were not correlated with TCD indices. Conclusion: No CDFI indices, except for the presence of carotid plaque, are correlated with TCD indices. Combined application of CDFI and TCD indices can better reflect the structure and hemodynamic status of cerebral vessels.

Objective This study is to explore the infratentoriat-supracerebellar keyhole approach for microsurgical treatment of pineal region tumors and to evaluate its curative efficacy and safety.Methods According to hi-fi quality MRI images,individual operation schemes were designed.Microsurgical infratentori- al-supracerebellar keyhole approach was used to resect lesions in 7 consecutive patients with prone postition.A 2.0 cm?2.5 cm surgical bone window was performed with its superior margin reaching to the inferior margin of the transverse sinus and confluence sinus.Results Among the 7 pineal region tumors,there were 2 ger- minomas,2 pineocytomas,1 pineoblastoma,1 glioma and 1 chlesteatoma.All cases were re-examined with MRI after operation and it was found that 6 lesions were totally removed and 1 was subtotally removed.The outcome of the treatment was satisfying.There was no infection,bleeding or death after surgery.The follow-up result in the near future was good.Conclusion The infratentorial-supracerebellar keyhole approach for the excision of pineal region tumors was proved to be a satisfactory means with a total removal rate,an excellent curative effect and small surgical trauma.

To study the effects of fractioned ir radiation on the total RNA and MDR 1 mRNA of NCI H 446 small cell lung cancer cell line, NCI H446 cells in the period of exponential growth were exposed to 60 Co ? radiation at 2 Gy/fraction, 2 fraction/week, with the cumulative dose of 50 Gy by 25 fractions. The total RNA of the cells of the irradiated group and control group were extracted by the acid guanidine thiocyanate phenol chloroform method and the amount of the expression of MDR 1 mRNA was assessed by qualitative RT PCR assays. Under the conditions of same cell number and volume, in cells of the control group, the concentration of the total RNA was 25 9 ?g/ml and the ratio of MDR 1 DNA/? actinDNA was 1 078, whereas in cells of the irradiation group, the corresponding values were 16 6 ?g/ml and 1 338, respectively. It is concluded that, for the NCI H446 small cell lung cancer cell line, a high dose accumulated during fractioned irradiation can inhibit the synthesis of its total RNA and enhance the expression of its MDR 1 gene at the same time.

[Objective]To discuss the causes and preventive measures of early complications after using Vertes technique in treating dens axis fracture with atlantoaxial dislocation.[Method]Eighteen cases performed Vertex technique were included in this study.The early complications(postoperative or at surgery) included vertebral artery injury(2 cases),logagnosia(1 case),anopsia(1 case),hematorrhea(1 case) and wrong instrumentation(1 case).The causes of these complications and how to prevent were analyzed.[Result]All these complications were treated in time,and no sequela was found.[Conclusion]The early complications of Vertex technique in treating dens axis fracture with atlantoaxial joint dislocation can be prevented.The timely treatment must be performed when it occurs,and the effect would be satisfactory.

In the circumstance of information age,this article made an analysis on the publish and distribution channels of medical professional literature.With the prosperity and development of the publishing industry,and diversified distribution channels,medical professional literature personnel must comply with the pace of the times,actively extended interview channels.