Objective To study the extraction technology of the polysaccharides from Sporophyll of Undaria pinnatifida Suringar and find out the optimum extraction condition.Methods The extraction technology was studied by the orthogonal design.Results The optimum extraction conditions were to add 50 times of water to the Undaria pinnatifida Suringar material at 90℃ for 4 hours.Conclusion This optimum extraction technology based on the orthogonal design was confirmed by the experiment and was available in the future research.

With the establishment of modern traditional Chinese medicine (TCM) as an oncology discipline, it has made great development and progress in the prevention and treatment of tumors. As a result, a number of academic thoughts and viewpoints have emerged. In the tumor field of TCM, the current representative theories include the theory of strengthening the body and treating cancer, the theory of treating from the membrane, the theory of surviving with tumor, the pathogenesis theory of cancer virus, the theory of consolidating the root and clearing the source, and the theory of regulating qi and detoxing. In TCM oncology, a large number of results have been achieved in the research of the thoughts of famous TCM doctors. However, discussions on these thoughts together are relatively few. This article summarizes and studies the above innovative theories from the aspects of academic connotation and clinical application to provide new ideas for further guiding the clinical practice of TCM oncology.

Investigator initiated trial （IIT） represents a primary format for clinical research in traditional Chinese medicine （TCM）. As key implementation sites for TCM-based IIT targeting malignant tumors， western medicine institutions often face unique challenges in conducting such studies， which limit their feasibility and standardization. This paper reviews the registration status of TCM-based IIT for malignancies conducted in western medical institutions and analyzes key difficulties， including complex project initiation and management processes， limited TCM knowledge and skills among western medicine physicians， and relatively low patient acceptance of TCM. From a practical perspective， the study proposes several optimization strategies. These include improving the review and management mechanisms of TCM-related IIT within western medical institutions， establishing multidisciplinary clinical research teams that integrate TCM and western medicine， and enhancing investigators' training in TCM theory and clinical skills. Additionally， the study suggests standardizing IIT operational procedures， objectifying the collection of TCM diagnostic information， refining subject recruitment methods， and increasing TCM involvement in patient follow-up and management. These investigator-oriented， TCM-featured， and operable strategies aim to promote the high-quality development of TCM-based IIT in western medicine institutions and enhance the clinical application of TCM.