P-glycoprotein(P-gp),the product of multidrug resistance gene MDR1,plays a very significant role in the ADME processes(absorption,distribution,metabolism,excretion)and drug-drug interaction of drugs in human.The magnitude of resistance depends on the expression of MDR1 up-regulated by chemotherapy.DNA sequence differences ale associated with phenotypic variation by various mechanisms,single-nucleotide polymorphisms(SNPs)is the most common of them.Genetic polymorphisms of MDR1 are associated with alteration in P-gp expression and function in different ethnicities and subjects.

To summarize clinical experience of Professor HE Tian-you in treating chronic prostatitis with combined acupuncture and herbs.His originally created acupoint ‘san yin xue’as the main points in the acupuncture treatment,and other acupoints were selected according to pattern and symptoms.He emphasized Deqi (acupuncture esthesia) and was good at performing needling manipulation. Based on the main pathogenesis of obstruction of liver liver channel,Prof HE chose Bupleurum chinense,Turmeric Root Tuber,Rhizoma,Szechwan Chinaberry Fruit,litchi,Oldenlandia and spina gleditsiae to compose the main formula.Furthermore,some other herbs were added or subtracted in main formula according to pattern and symptoms.

The paper analyzes current situation of the non -medical majors and literature information retrieval course in Traditional Chinese Medicine ( TCM) colleges and universities , points out the course reform objectives and key points .By taking Liaoning Universi-ty of Traditional Chinese Medicine as an example , it discusses the characteristics of non -medical majors and needs for the literature in-formation retrieval course , and proposes the teaching approach of literature information retrieval course for non -medical majors in TCM colleges and universities .

Objective To find out evidences for the identification of Ajuga decumbens Thunb.(Jinchuangxiaocao) and Pogostemon cablin (Blanco.) Benth.(Guanghuoxiang) . Methods Fresh stems and leaves of the two species were collected and used as the samples. We used stereoscopy to observe and compare the macroscopic appearance of the original plants, and used light microscope to observe the stem cross-section, petiole cross-section, leaf epiderm and powder of the two species for microscopic identification. Results The results of macroscopic character identification showed that the petiole of Jinchuangxiaocao had narrow wing, while that of Guanghuoxiang had no narrow wing; the angles between leaf main vein and lateral vein of Jinchuangxiaocao were less than 45°, while the angles of Guanghuoxiang were more than 45°. In respect of microscopic identification, Jinchuangxiaocao had the glandular scales with multicellular head, and Guanghuoxiang had the glandular scales with one-celled head; the intercellular space and crystals were found in the cortex of Guanghuoxiang stems and mesophyll, while Jinchuangxiaocao has no such structures. Jinchuangxiaocao had diacytic and anomocytic stomata, and Guanghuoxiang only had diacytic stomata. Conclusion The appearance and microscopic differences can be used for the identification of Jinchuangxiaocao from Guanghuoxiang.

Objective To study the influence of different dosages of atorvastatin in acute coronary syndrome female patients on vascular endothelial growth factor(VEGF) and brain natriuretic peptide(BNP).Methods 60 female cases of ACS patients were divided into A and B group.30 patients in the A group were given atorvastatin 20mg per night,while the other 30 patients in the B group were taken 40mg per night.The patients were followed four weeks by evaluating serum VEGF and BNP concentration.Results After treatment for four weeks,the patients in the two groups showed significant reduction in VEGF and BNP,however,the therapeutic group showed significant difference between the two groups.Additionally,the B group further showed significant reduction in VEGF and BNP.Conclusion Using high-dose atorvastatin lowers VEGF and BNP significantly,which could reduce female cardiovascμlar events.

[Objective] To provide a basis for the identification of six species of Calicarpa. [Methods] Histological and microhistological features were studied. [Results] Obvious distinctive features of color and types of villi on the back of the leaf were found. [Conclusion] The method can be used to distinguish the features of the six species of Calicarpa.

Adult ; Aged ; Aged, 80 and over ; Anti-Infective Agents ; pharmacology ; therapeutic use ; Cross Infection ; drug therapy ; microbiology ; Female ; Hospitalization ; Humans ; Inpatients ; Male ; Middle Aged ; Pneumoconiosis ; microbiology ; Pneumonia ; drug therapy ; microbiology ; Retrospective Studies

Objective To investigate the imaging and condylar movements during mandibular opening/closing movement in AngleⅡ2 malocclusion accompanying one side of temporomandibular joint(TMJ)click before and after orthodontic treatment.Methods There were 20 AngleⅡ2 malocclusion patients with one side of TMJ click in treatment group,and 23 with the individual normal occlusion in control group.This study was performed taking the films of Sch?ller position before and after treatment,using CADIAX to record the condylar tracings during opening/closing movement and analyze the qualitative and quantitive changes.Results In AngleⅡ2 malocclusion patients,the condylar position of 58.33% patients recovered from retroposition to mesoposition.The condyle movement presented conspicuous verticality,the smoothing and symmetry were not well,and obvious improvements were observed after the treatment.All the index changed remarkably except the TCI and TCI of 5 mm.Conclusion It is suggested that orthodontic treatment can make the disc-condyle relationship return to normalization,and the condylar movement become much more coherent.

Objective: To observe the clinical effect of integrated traditional and western medicine in treating chronic idiopathic thrombocytopenic purpura (CITP) elderly patients. Methods: Sixty patients were divided randomly into the treatment group (n=30) and the control group (n=30), the former was treated with danazol combining with prednisone and Chinese drugs, while the latter was treated with VCR. Results: The total effective rate of the treatment group was better than that of the control group, the difference between those two groups was significant (P

Objective To evaluate the effect of lifestyle intervention on the indexes of patients with dyslipidemia.Methods CNKI,Wanfang Database,VIP,PubMed,Web of Science,EBSCO,EMbase,the Cochrane Library,Clinical Trials,MEDLINE were retrieved.The search terms included lifestyle intervention,lifestyle,diet,physical activity,dyslipidemia,hypercholesterolemia,lipid,low fat diet,plant sterols,low-glycemic index(GI)diets,mono-unsaturated fatty acids.Articles on randomized controlled trials(RCTs)to study the effect of lifestyle intervention on the indexes of patients with dyslipidemia were screened according to inclusion and exclusion criteria.Meta-analyses were conducted by using RevMan 5.3 software after extracting data.Results 19 articles were internalized,including 2 294 patients(intervention group,n=1,170)and(control group,n =1,124).According to the results of intervention group versus control group,total cholesterol of weighted mean difference(WMD)was (-0.61,95 ％CI.-0.84～-0.38,P＜0.01),triglyceride of WMD was(-0.28,95 ％ CI:-0.42～ 0.15),P＜0.01),low-density lipoprotein cholesterol of WMD was (-0.45,95 ％ CI:-0.72 ～ 0.18,P ＜0.01),(all P＜0.01),with significantly lower WMD in intervention group than in control group.The high-density lipoprotein cholesterol of WMD was (-0.05,95 ％ CI:-0.22 ～ 0.12,P =0.59),the difference was not significant.Conclusions Lifestyle intervention improves serum levels of total cholesterol,triglyceride and low-density lipoprotein cholesterol for dyslipidemia patients,but its effect on high-density lipoprotein cholesterol is not significant.