Objective To identify the value of medical journals by analyzing the papers covered in Medical F1000. Methods The papers published before November 2012 recommended by Medical F1000 were retrieved,the recommended ratios of the total number of papers published in journals each year were calculated and ranked.Results A total of 27960 papers were recommended by Medical F1000.Of these papers,801 were published in New England Journal of Medicine and ranked first.A great difference was found in the number of papers ranked according to their recommended ratios and the recommended number of papers.Conclusion Only a small number of papers are recommended by Medical F1000.However,they can help readers access to the valued medical information in the shortest time.The recommended ratio and the recommended number of papers are the important evidence for the assessment of journals.

To find out whether articles that recommended by F1000 medical edition really contain more valuable information than others.Thirty articles published in NEJM were selected from F1000 medical edition (Group A).For each article that entered our collection,another article was picked out from the same issue as control (Group B).ISI Web Service was usedto gain the cited times of these selected articles.The results were statisticallyanalyzed with paired t test.Total cited times were range from 54 to 1 256 in group A versus 20～614 in group B,with 345.2 versus 198.6 in meantimes.Meancited times of first three years was 144.2 in group A versus 88.9 in group B and 210 versus 109.8 in the years that follows.Cited times of articles in group A was higher than that of group B significantly (P=0.05,t=2.430 9).F1000 articles contain more valuable information than others and can act as an important role in acquiring high quality medical information.As F1000 does not contain all high quality information in medical field,other tools are needed if onewants to get all of the concerning information.

10.3969/j.issn.2095-4344.2013.23.022

Probiotics modulate the biological functions (and even cell apoptosis) of intestinal epithelial cells,intestinal macrophages,intestinal dendritic cells,and T cells via cell signaling pathways including nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.Peroxisome proliferator-activated receptor γ (PPARγ) and heat shock protein (hsp) are targets for probiotics or their products.

Humans ; Laryngostenosis ; diagnosis ; etiology ; surgery

Humans ; Laryngostenosis ; diagnosis ; etiology ; therapy ; Tracheal Stenosis ; diagnosis ; etiology ; therapy

Narrative medicine adds new elements for the development of medical humanistic education .It pro-vides a new perspective to re -examine the doctor -patient relationship .From medical humanities and narrative and narrative ability is medical students overall development reality needs two aspects analyzes the narrative ability training medical students is a new requirement , medical humanities education narrative medical practice signifi-cance is not only reflected in promoting the medical work of humanity , but also in the training process for medical students through the narrating ability .

Objective To study the inhibitory effects of cyclosporine A (CsA) on the laryngeal allograft rejection and corresponding histological changes,and the relation to the CsA dose.Methods The Wistar rats as recipients were divided into control group(without CsA)and two experimental groups:group Ⅰ and group Ⅱ receiving CsA 15 mg/kg and 25 mg/kg daily for 2 weeks respectively.Topographic anatomically and histologically,the survival of the laryngeal allografts was evaluated.Results Obvious histologic evidence of acute rejection of the laryngeal allografts was found in the control group.In the two experimental groups,the histological changes was obviously lessened 7 days after operation as compared with those in the control group,and the tissue structure of the laryngeal allografts was kept intact 14 days after transplantation.In the group Ⅱ,2 allografts histologically showed an increase in inflammatory cells in the lamina propria,predominantly polymorphonuclear leukocytes,with associated edema.surface epithelium and minor salivary gland acini were damaged,with focal ulceration and acinar micro-abscesses.The other case only exhibited slight rejection.Conclusion CsA can effectively prevent rejection of laryngeal allografts and block the development of injury of allografts from SD rat donors to Wistar recipients.The dosage and the pattern of administration of CsA may be closely related to its efficacy.The increased infection rate of the allografts may possibly be contributed to the higher CsA doses employed.

The expression of genes have an important effect to gastric cancer chemotherapy.Some genes are related the therapeutic efficacy of drugs,some genes are related the untoward effects of drug,and some genes are related the sensitivity of the tumor to drug.Chemotherapy related genes may play an important guiding role to improve the curative effect of chemotherapy patients.In recent years,the gastric cancer chemotherapy related genes have made great progress,especially in platinum,fluorouracil,paclitaxel and targeted medicine related genes.

Objective To determine the proportion and the clinical value of the thymus extending superiorly into the lower neck in children.Methods The MR images of 400 normal children were retrospectively reviewed.According to the childhood staging criteria.all children were divided into four groups:the infancy and toddlerhood group(0-3 yo,42),the pre-school age group(>3-6 yo,87),the school age group(>6-12 yo,168),and the adolescence group(>12-18 yo,103).The presence or absence of the superior extension of the thymus above the manubrium Was determined on sagittal T2-weighted images.If so,the distance between manubrium and thymic apex was measured.The associations between frequency of ccrvicaI extension and age and sex were evaluated using correlation analysis.Results Superior extension of the thymus was detected in 288(288/400,72.0%)children,with 39(39/42,92.9%)in the infancy and toddlerhood group,72(72/87,82.8%)in the pre-school age group,118(118/168,70.0%)in the school age group,and 59(59/103)in the adolescence group(57.3%).There Was a statistically significant relationship between age group and frequency of cervical extension of the thymus (X2=4.9684,P<0.05).There was no significant decreasing trend in the mean distance of cervical extension between age increasing groups(F=2.28,P>0.05).Conclusions Cervical extension of the thymus occurs in the majority of children,and should be considered as a normal finding.Through recognizing this finding,doctors can avoid misdiagnosing it as a pathologic mass.