Objective To observe the effect of nasal inhalation of Compound Acorus Liquid(CAL) and oxygen on the recovery of nervous function in cerebral infarction patients.Methods Forty ischemic stroke patients were equally randomized into the treatment group and the control group.The two groups received anti-fibrinogen drug,antiplatelet aggregation drug,and symptomatic treatment;additionally,the treatment group received nasal inhalation of CAL and oxygen,and the control group received nasal inhalation of CAL and oxygen.Ten times constituted one treatment course,and the treatment lasted two courses.Therapeutic effect was evaluated,and the changes of nervous function were assayed by MESSS scoring and Barthel index,and activities of daily life(ADL) were also observed.Results The total effective rate was 90.0% in the treatment group and 55.0% in the control group(P

Objective To analyze the therapy method and the therapeutic effect of Jones fracture by using hollow screw internal fixation.Methods All the Jones fractures were treated by open reduction hollow screw internal fixation and the plaster external fixation were not used after operation.Results The 32 cases with Jones fractures got excellent 25 cases,good 6cases and poor 1 case which used by Maryland foot score system to appraisal.All the cases were followed up for 6 months to 30 months and the average follow-up time is 18 months.Conclusion The treatment of hollow screw internal fixation was a satisfactory method to cure Jones fracture,which had get advantages of simple operation,small wound,short operation time,not external fixation,quick recovery and few complications.

Objective: To study the chemical constituents in the twigs and leaves of Ervatamia hainanensis. Methods: The chemical constituents were isolated by silica gel, ODS, Sephadex LH-20 column chromatographies, and preparative HPLC. The structures were elucidated on the basis of physicochemical properties and spectral analysis. Results: Four lignans were isolated and identified as threo-7-O-ethylguaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (1), threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (2), erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (3), and dehydrodiconiferyl alcohol (4). Conclusion: Compound 1 is a new 8-O-4'-neolignan and named as hainanervaligan A (1), and compounds 2-4 are obtained from the plants of Ervatamia (A. DC.) Stapf for the first time.

Objective To explore the dynamic changes of neuron-specific enolase (NSE) and myelin basic protein (MBP) in serum of rats with temporal epilepsy (EP) induced by kainic acid (KA) and to judge the degree of injury of brain neuron and nerve myelin after seizure.Methods KA was injected into rat's hippocampus by stereotactic operation to establish an animal model of temporal EP.The levels of NSE and MBP in serum of rats with temporal EP were measured at the time 3 h,6 h,12 h,24 h,48 h and 72 h after seizure.Results The level of NSE in serum increased gradually and reached its peak at 24 h after seizure, as well as MBP at 72 h.Conclusions There are the nerve cell damage and necrosis after seizure in rats with temporal EP, then brain white matter nerve myelin appear to damage.

Objective To evaluate the inhibiting effect of selective and non-selective cyclo-oxygenase-2(COX-2) inhibitor on growth of colon cancer cell lines in vitro and its signal transduction pathway. Methods The proliferation of colon cancer cells was determined by MTT assay. COX-2, nuclear factor(NF)-?Bp65, extracellular-signal regulated kinase(ERK), phospho ERK(pERK) protein expressed in colon cancer cell lines were analyzed by Western blot. Activator protein(AP)-1 and NF-?B binding activity influenced by non-steroidal anti-inflammatory was detected by electrophoretic mobility sift assay. Results Aspirin and celecoxib could inhibit the proliferation of HT-29, SW480 and LS174-T cells and showed a dose-dependent manner. Western blot analysis showed that expression of COX-2, pERK, NF-?Bp65 protein in colon cancer cells were down-regulated by celecoxib or aspirin in some degree but not effect in total ERK expression. AP-1 and NF-?B binding activity could be stimulated by 20% fetal calf serum or tumor necrosis factor-?. Both aspirin and celecoxib could inhibit fetal calf serum-induced AP-1 activation in HT-29 and SW480 cells. Celecoxib could also inhibit tumor necrosis factor induced NF-?B binding activity, but aspirin had little effects on SW480 cells. Conclusion NSAIDs are able to potentially inhibit the growth of colon cell lines in vitro and the mechanism may relate to AP-1 and NF-?B signal transduction pathway.

Objective To evaluate the quality of Cortex Cinnamomi from genuine producing areas and GAP planting base,and to compare with those of the commercial medicinal materials.Methods A RP-HPLC method was carried out to determine the content of cinnamyl aldehyde in cortex cinnamomi.Combined with the comparison of volatile oil yield,total ash content and acid-insoluble ash content,the quality of the samples was evaluated with the index of cinnamyl aldehyde content.Results The total ash contents and acid-insoluble ash contents of all samples were in the normal range.Cinnamyl aldehyde contents and volatile oil yields for samples from genuine producing areas and GAP planting base were up to the pharmacopoeia.There was a great fluctuation in cinnamyl aldehyde contents and volatile oil yields in commercial materials.Conclusions The quality is good and stable for the samples from genuine producing areas and GAP planting base,but it is not stable for the commercial materials.

Objective To investigate the effects of glucocorticoid(GC) on the expression of CD80 and CD4+CD25+T cells in peripheral blood lymphocyte of patients with multiple sclerosis (MS). Methods With flow cytometer,the positive rates of CD80 and CD4+CD25+T cells in peripheral blood lymphocyte were detected in 21 acute MS patients pre and post treatment separately,and compared with the nomal control group.The secols of Expanded Disablility Status Scale(EDSS) were compared pre and post treatment in MS patients.Results The positive rate of CD80[(5.031?1.782)%]in the MS patients pre treatment was obviously less than that in control group's [(6.436?2.035)%](P

Objective To investigate the dynamic enhanced CT scanning in differentiation of small lung cancer.Methods 20 patients with pathologically confirmed small lung cancer,and 6 patients with inflammatory nodules,5 patients with tuberculoma were studied with plain chest CT scan and dynamic enhanced (the delay time of scans was 30 s,1,3,5,7 min after injection)before surgery.Then the enhancement degree of the lesions was recorded in different time lag.The time-attenuation curves of different diseases were drawn.Results Tuberculoma showed a significantly lower degree of enhancement than the pulmonary carcinoma and inflammatory nodules,it showed a lower and flat line.The carcinoma and the inflammation showed no differences in degree of enhancement.But the peaks of the tow curves appeared to be different in various time of delay,tumor reached its peak in 1～3 minute after injection of contrast medium which dropped behind the inflammatory.Conclusion The results suggested that from the time-attenuation curve we could make the different diagnosis between small lung lesions.

[Objective]To investigate the curative effect of intermittent pneumatic compression(IPC) in the treatment of deep venous thrombosis(DVT) after interventional thrombolysis.[Method]Fifty-two cases of DVT were treated from December 1998 to August 2007,and divided into 2 groups randomly.In the first group,all cases received low molecular heparin and warfarin after routine or interventional thrombolysis.In the second group,IPC was used on the basis of group one.Two groups were compared about cases for repeated thrombolysis,time point of symptom relief,reduction of swelling at 7 days after surgery,re-canalization of vein at 1 month after surgery.[Result]Three cases in the first group needed repeated thrombolysis while none was found in the second group.In the second group,quicker symptom relief,more obvious reduction of swelling,wider re-canalization of vein were observed compared with the first group.[Conclusion]IPC is proved effective in the comprehensive therapy of DVT.

Objective To investigate corneal shape changes following three different surgical procedures of retinal and vitreous surgery. Methods A total of 41 eyes of 41 patients were divided into 3 groups based on the type of surgical procedure: encircling with vitrectomy, encircling with additional segmental buckling, and local buckling. The corneal shapes of these eyes were examined by corneal topographic machine before operation and one week, one month, and three months after operation. Results Corneal astigmatism and surface asymmetry index(SAI) significantly increased one week after operation compared with before operation (P