1.Progress on roles of type 2 innate lymphoid cells in the pathogenesis of asthma
Journal of Clinical Pediatrics 2017;35(2):148-152
Type 2 innate lymphoid cell (ILC2) is a new member of the innate lymphoid cell family discovered recently. After being exposed to antigens, ILC2 was activated by epithelial cell-derived cytokines, lipid mediators and TNF family member TL1A to promote structural and immune cell responses in the airways. These cells are critical components of the innate immune response involved in the pathogenesis of asthma. This paper summarizes the progress on the roles of type 2 innate lymphoid cells in the pathogenesis of asthma.
3.Brain Efficient Connectivity Analysis of Attention Based on the Granger Causality Method.
Journal of Biomedical Engineering 2016;33(1):56-60
The study of brain information flow is of great significance to understand brain function in the field of neuroscience. The Granger causality is widely used functional connectivity analysis using multivariate autoregressive model based on the predicted mechanism. High resolution electroencephalogram (EEG) signals of ten healthy subjects were collected with a visual selective attention task. Firstly, independent component analysis was used to extract three spatially independent components of the occipital, parietal, and frontal cortices. Secondly, the Granger causal connectivity was computed between these three regions based on the Granger causality method and then independent sample t-test and bootstrap were used to test the significance of connections. The results showed that Granger causal connectivity existed from frontal to occipital and from parietal to occipital in attentional condition, while causal connectivity from frontal to occipital disappeared in unattentional condition.
Algorithms
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Attention
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Brain
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physiology
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Electroencephalography
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Healthy Volunteers
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Humans
4.Promotion of Pink1S Auto-phosphorylation with CK2β.
Journal of Biomedical Engineering 2015;32(5):1056-1060
The aim of this study is to determine the regulatory mechanism of PTEN-induced putative kinase protein 1 short isoform (PINK1S) in cytoplasm. By co-immunoprecipitation (Co-IP) assay, we identified that PINK1S interacted with the beta regulatory subunit of Casein Kinase 2 (CK2β), but not with the catalytic subunits CK2α1 and CK2α2. Furthermore, cells were transfected with PINK1S and CK2β, and then PINK1S was purified by immunoprecipitation. After detecting the phosphorylated proteins by Phos-tag Biotin, we found that CK2β overexpression increased auto-phosphorylation of PINK1S. Finally, we generated CK2β knockdown cell lines by RNA interference. Purified PINK1S from CK2β knockdown cells significantly reduced its auto-phosphorylation compared with control cells. These results suggested that CK2β functions as a regulatory subunit of PINK1S kinase complex promoted its activation by self-phosphorylation.
Biotin
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Casein Kinase II
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metabolism
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Cell Line
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Gene Knockdown Techniques
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Humans
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Phosphorylation
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Protein Kinases
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metabolism
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Pyridines
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RNA Interference
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Transfection
5.The correlation study between resilience and coping styles of recurrence of patients with nasopharyngeal neoplasms
Chinese Journal of Practical Nursing 2015;31(15):1165-1167
Objective To investigate the relationship between levels of psychological resilience and coping styles of the patients with recurrence of nasopharyngeal neoplasms during hospitalization,in order to provide scientific data about the clinical psychological intervention.Methods A total of 240 cases of hospitalized patients with recurrence of nasopharyngeal neoplasms were selected and measured with general information questionnaire which was self-designed,resilience scale (CD-RISC) and coping scale.Results Resilience average score of patients with recurrent nasopharyngeal neoplasms was (53.22 ± 12.09) points,the level of resilience was positively correlated with positive coping and avoidance coping,P<0.05,and negatively correlated with the yield coping,P<0.05.Conclusions The resilience levels in patients with recurrence of nasopharyngeal neoplasms is below the medium level,resilience have a significant impact on patients' coping styles,and coping styles is affecting the level of resilience.In clinical work,health care workers should take effective measures to improve the resilience of patients so that patients take positive coping with disease.
6.American Medicare Experiences and Implications of Inpatient Hospital Payment Reform for China
Chinese Health Economics 2013;(6):95-97
To discuss background of Medicare hospital payment system reform in the U.S., its legislative and administrative system and the key issues incurred during the design and implementation process, then summarized the experiences and lessons and suggestions were proposed for current provider payment reforms in China.
7.Combined operation for the relaxation of degenerative entropion
International Eye Science 2014;(7):1352-1353
AlM:To analyze and explore the clinical efficacy of strengthening lateral tarsal strip and advancing lower eyelid retractor for the treatment of degenerative entropion with eyelid relaxation
METHODS: Reviewed from January 2011 to January 2013, 21 cases (33 eyes) of degenerative entropion eyelid relaxation were treated with operation of strengthening lateral tarsal strip and advancing lower eyelid retractor ( fornix conjunctival incision ) , the follow-up was 12-24mo, curative effect was observed.
RESULTS: All the patients were cured completely, have no recurrence or overcorrection phenomenon. The cure rate of operation was 100%, there was no complication.
CONCLUSlON: Operation of strengthening lateral tarsal strip and advancing lower eyelid retractor is a safe, reliable, efficient operation to the treatment of degenerative entropion with mode of eyelid relaxation.
8.Effect of Danshen injections on NT-proBNP in patients with hypertension and left ventricular failure
International Journal of Laboratory Medicine 2016;37(19):2728-2729
Objective To study the effect of Danshen injection on brain peptide type B (NT‐proBNP) in patients with hyperten‐sion and left ventricular failure ,provide an effective basis for clinical treatment .Methods Totally 80 patients of hypertension with left heart failure from February 2015 to February 2016 were randomly divided into two groups :40 patients were treated with con‐ventional therapy (control group ) ,40 patients in the conventional treatment combined with Danshen injection (experimental group) .We compared NT‐proBNP ,inflammatory factors and clinical efficacy between two groups .Results Before treatment ,the expression of NT‐proBNP and hs‐CRP ,NT‐proBNP level was basically the same in two groups (P> 0 .05) .After treatment ,the ex‐perimental group of patients with NT‐proBNP was significantly lower than the control group and the LVEF ,left ventricular mass index and left ventricular volume index were significantly higher compared with the control group (P< 0 .05) .The total effective rate of patients in Danshen injection groups was significantly higher (P< 0 .05) .Conclusion The injection of Danshen in patients with hypertension and heart failure patients can significantly improving NT‐proBNP levels and improve the cardiac function .
9.Discussion on Day Surgery Payment Method
Shengjie JIANG ; Qin JIANG ; Zhenzhong ZHANG
Chinese Health Economics 2013;(6):13-14
Through analyzing domestic medical service payment method and day surgery payment method in USA and Australia, combine the current domestic progress of day surgery and its main prevailing payment to explore the future day surgery payment system in China.
10.Operative treatment of crescent fracture of the pelvis by posterior approach
Hui QIN ; Zhiquan AN ; Chaolai JIANG
Chinese Journal of Orthopaedic Trauma 2011;13(9):822-823
ObjectiveTo explore the efficacy of posterior approach in treatment of crescent pelvic fracture.MethodsBetween April 2007 and January 2010, 12 patients with crescent pelvic fracture were treated via posterior approach at our department. They were 8 men and 4 women, aged from 21 to 55 years (average, 31.3 years). Six left and 6 right sides were affected. The fractures were caused by a traffic accident in 8 cases, high falling in 3 cases and heavy weight crushing in one. By Tile classification, there were 8 cases of type B2. 1 and 4 cases of B2.2. The time from injury to operation was 3 to 9 days, with an average of 6. 2 days. They were treated with open reduction and internal fixation via the posterior approach. Operation time,intraoperative blood loss, postoperative loss of pelvic ring reduction, fracture healing time and Hannover pelvic outcome scoring were documented.ResultsThe average operation time was 172.5 ± 34. 1 minutes(from 120 to 240 minutes) . The average blood loss was 412.5 ±- 128.1 mL(from 250 to 700 mL) . The average reduction gained was 11.7 ±4. 6 mm(from 6 to 21 mm). Ten patients obtained an average follow-up of 16. 3 months (from 12 to 20 months). The X-ray films showed bony healing in all patients after an average of 3. 1 ± 0. 3 months(from 3 to 4 months). There was no postoperative loss of pelvic ring reduction or implant failure.By the Hannover scoring system, 7 patients were rated as excellent and 3 as good in clinic symptoms, and complete social reintegration was obtained in 8 cases and incomplete one in 2 cases.ConclusionOperation via posterior approach is a good choice for treatment of crescent pelvic fracture.