OBJECTIVE: To compare the therapeutic effect of postoperative radiotherapy with surgery alone in advanced supraglottic laryngeal squamous cell carcinoma (LSCC). METHOD: According to the treatment methods, 59 patients with advanced supraglottic LSCC were divided into surgery plus radiotherapy group (S+R group) (33 cases) and surgical group (S group) (26 cases). In S+R group, total laryngectomy was performed on 27 patients and partial laryngectomy on 6 patients, 27 of whom underwent lateral neck dissections; while in S group, total laryngectomy was performed on 23 patients and partial laryngectomy on 3 patients, 24 of whom underwent lateral neck dissections. RESULT: The 3-year overall survival rate of S+R and S group were 62.6% and 62.6% respectively, and the 5-year overall survival rate of S+R and S group were 43.8% and 40.5% respectively. But there was no statistically significant difference of survival rate between two groups by Log-rank test (P > 0.05). In S+R group, recurrence happened in 5 cases and the recurrent rate was 15.1%; in S group, recurrence happened in 10 patients and the recurrent rate was 38.5%, statistically significant difference was found between the two recurrent rates (P < 0.05). CONCLUSION Surgery combined with postoperative radiotherapy could not improve the 3-year-or 5-year overall survival rate, but could significantly reduced tumor recurrence rate.
Adult ; Aged ; Carcinoma, Squamous Cell ; pathology ; radiotherapy ; surgery ; Combined Modality Therapy ; Female ; Glottis ; pathology ; Head and Neck Neoplasms ; pathology ; radiotherapy ; surgery ; Humans ; Laryngeal Neoplasms ; pathology ; radiotherapy ; surgery ; Laryngectomy ; Male ; Middle Aged ; Neck Dissection ; Squamous Cell Carcinoma of Head and Neck ; Survival Rate ; Treatment Outcome

OBJECTIVE: This study was to evaluate the patterns of central lymph nodes metastasis, by analyzing the results of surgery in clinical NO (cNO) papillary thyroid carcinoma (PTC). METHOD: We retrospectively studied the effect of surgical treatment among 123 cN0 PTC patients. All the patients underwent central lymph node dissection; 47 patients underwent ipsilateral neck dissection and 9 patients underwent bilateral neck dissection. RE- SULT: Seventy-eight cases (63.4%)were found positive central lymph node, which included 34 cases (27.6%) bilateral positive central lymph node. Central lymph node metastases correlated with age < 45 years, extrathyroidal extension, surrounding tissue invasion and tumor size grade (P < 0.05), were the independent risk factors of central lymph node metastasis. CONCLUSION Age < 45 years, extrathyroidal extension and surrounding tissue invasion were the independent risk factors of central lymph node metastasis. For cNo patients with PTC, primary excision as well as central neck dissection was recommended; according to the results of intraoperative frozen and situation, further process were made.
Adult ; Carcinoma ; pathology ; Carcinoma, Papillary ; Humans ; Lymphatic Metastasis ; Neck Dissection ; Retrospective Studies ; Risk Factors ; Thyroid Cancer, Papillary ; Thyroid Neoplasms ; pathology