Adenoviridae ; immunology ; Antigens, Viral ; analysis ; Child ; Fluorescent Antibody Technique ; Humans ; Respiratory Syncytial Viruses ; immunology ; Respiratory Tract Infections ; immunology ; Respirovirus ; immunology ; Virus Diseases ; immunology

Objective To evaluate the accuracy of a novel echocardiographic three-dimensional automated software for the assessment of the aortic root in candidates for transcatheter aortic valve replacement(TAVR).Methods Four patterns(Lax,Lax-Res,Sax,Sax-Res) of 3D-TEE imaging of aortic root were gotten preoperatively in 18 patients with severe tricuspid aortic stenosis who were referred to our center for TAVR.The specialized 3D-TEE reconstruction software,eSie Valves,then automatically configured a geometric model of the aortic root from the images obtained by 3D-TEE and performed a quantitative analysis of these structures:the minimal diameter(Dmin),maximal diameter(Dmax),area and perimeter(Peri) of aortic annulus,height of the ostia of the left/right coronary artery above the aortic annulus(LOH/ROH).The echo dimensions were compared with the MDCT measurements.Results No statistically significant difference were found in above parameters between the ZOOM pattern (Sax-Res and Lax-Res) and CT measurements(all P>0.05).Lax-Res pattern measurements had good correlation with MDCT,with r valves of 0.81,0.77,0.89,0.84 for Lax-Res-Dmin,Lax-Res-Dmax,Lax-Res-Area,Lax-Res-Peri,respectively(all P<0.05).3D-TEE LOH/ROH had poor correlation with MDCT LOH/ROH (all r<0.7).Conclusions The new automatic 3D-TEE software allows modelling and quantifying the aortic annulus dimensions from 3D-TEE data in patients with tricuspid aortic valves,and Lax-Res pattern is recommended.Quantified assessment of LOH/ROH is not ideal and needs to be improved.

Objective To analyze the present situation and reasons of short-term unplanned extubation after peripherally inserted central venous catheters (PICC)surgery in cancer patients. Methods A total of 2 458 cancer patients underwent PICC surgery were collected,and patients experienced short-term unplanned extubation were screened out to analyze the general information, catheter situation and reasons of unplanned extubation.Results Totally 2 431 cases (98.90%, 2431 /2458)were successfully followed-up and 103 patients (4.24%,103 /2431)experienced short-term unplanned extubation.Among them,the proportion of patients received primary PICC,pa-tients over 65 years old and patients with catheter located in median cubital vein were 96.12%(99 /103),59.22% (61 /103)and 46.60% (48 /103)respectively.The incidence of unplanned extubation were related to age,vascular choose and whether the primary PICC.Subjective will (61.17%,63 /103)of patients was the main reason for short-term unplanned extubation and the objective reasons were catheter prolapse (10.67%,11 /103),local thrombosis (7.77%,8 /103) and puncture site exudation /phlebitis(6.80%,7 /103),catheter-related infections (5.83%,6 /103)and so on.Conclusion Effective maintenance during the entire process after PICC such as adequate doctor-patient communication,positive patient education,strengthening outside hospital PICC maintenance training as well as establishment of good follow up system can reduce the inci-dence rate of short-term unplanned extubation.

Objective To analyze the present situation and reasons of short-term unplanned extubation after peripherally inserted central venous catheters (PICC)surgery in cancer patients. Methods A total of 2 458 cancer patients underwent PICC surgery were collected,and patients experienced short-term unplanned extubation were screened out to analyze the general information, catheter situation and reasons of unplanned extubation.Results Totally 2 431 cases (98.90%, 2431 /2458)were successfully followed-up and 103 patients (4.24%,103 /2431)experienced short-term unplanned extubation.Among them,the proportion of patients received primary PICC,pa-tients over 65 years old and patients with catheter located in median cubital vein were 96.12%(99 /103),59.22% (61 /103)and 46.60% (48 /103)respectively.The incidence of unplanned extubation were related to age,vascular choose and whether the primary PICC.Subjective will (61.17%,63 /103)of patients was the main reason for short-term unplanned extubation and the objective reasons were catheter prolapse (10.67%,11 /103),local thrombosis (7.77%,8 /103) and puncture site exudation /phlebitis(6.80%,7 /103),catheter-related infections (5.83%,6 /103)and so on.Conclusion Effective maintenance during the entire process after PICC such as adequate doctor-patient communication,positive patient education,strengthening outside hospital PICC maintenance training as well as establishment of good follow up system can reduce the inci-dence rate of short-term unplanned extubation.

ABSTRACT:Objective To explore the correlation between the psychological resilience and quality of life in breast cancer patients with chemotherapy.Methods From January 2012 through December 2013,80 breast cancer patients with adjuvant hormonal therapy were selected as object. The psychological resilience was assessed by Conner-Davidson Resilience Scale and the quality of life was assessed by Functional Assessment of Cancer Therapy-Breast (FACT-B)at 1 month and 6 months after chemotherapy.The correlation between the psychological resilience and quality of life was assessed by Spearman correlation analysis.Results The total scores of psychological re-silience in breast cancer chemotherapy patients at 1 month and 6 months after chemotherapy were (45.72±8.44)and (49.35±8.27),which were significantly lower than (65.4±13.9)of the do-mestic norm (P <0.05).The scores of tenacity,self reliance and optimism in breast cancer chemotherapy patients were also lower than those of the domestic norm (P <0.05).Spearman correlation analysis showed that the psychological resilience had positive correlations with physical dimension,social /family dimension,emotional dimension and functional dimension (P <0.05). Conclusion Psychological resilience in breast cancer chemotherapy patients is low,and it shows a positive correlation with quality of life.The strength of the resilience in breast cancer chemothera-py patients can help promote their quality of life.

ABSTRACT:Objective To explore the correlation between the psychological resilience and quality of life in breast cancer patients with chemotherapy.Methods From January 2012 through December 2013,80 breast cancer patients with adjuvant hormonal therapy were selected as object. The psychological resilience was assessed by Conner-Davidson Resilience Scale and the quality of life was assessed by Functional Assessment of Cancer Therapy-Breast (FACT-B)at 1 month and 6 months after chemotherapy.The correlation between the psychological resilience and quality of life was assessed by Spearman correlation analysis.Results The total scores of psychological re-silience in breast cancer chemotherapy patients at 1 month and 6 months after chemotherapy were (45.72±8.44)and (49.35±8.27),which were significantly lower than (65.4±13.9)of the do-mestic norm (P <0.05).The scores of tenacity,self reliance and optimism in breast cancer chemotherapy patients were also lower than those of the domestic norm (P <0.05).Spearman correlation analysis showed that the psychological resilience had positive correlations with physical dimension,social /family dimension,emotional dimension and functional dimension (P <0.05). Conclusion Psychological resilience in breast cancer chemotherapy patients is low,and it shows a positive correlation with quality of life.The strength of the resilience in breast cancer chemothera-py patients can help promote their quality of life.

Objective:To investigate the correlation between white matter hyperintensities (WMHs) and the outcomes after reperfusion therapy in patients with acute ischemic stroke (AIS).Methods:Patients with AIS treated with reperfusion therapy (intravenous thrombolysis, endovascular mechanical thrombectomy or bridging therapy) in the Stroke Center of Zhongshan Hospital of traditional Chinese Medicine from January 2014 to December 2019 were retrospectively enrolled. The clinical baseline data of the patients were collected. The Fazekas scale was used to evaluate the severity of WMHs according to the MRI images. At 90 d after discharge, the modified Rankin Scale was used to evaluate the outcomes. A score of ≤ 2 was defined as good outcome, and a score of >2 was defined as poor outcome. Binary multivariate logistic regression analysis was used to determine the independent risk factors for hemorrhagic transformation (HT), symptomatic intracranial hemorrhage (sICH), and poor outcomes. Results:A total of 676 patients with AIS treated with reperfusion therapy were enrolled. Among them, 506 patients (74.9%) were complicated with WMHs, and 80 (11.8%) had severe WMHs. One hundred and thirty-two patients (19.5%) had HT, 34 (5.0%) had sICH, and 306 (45.3%) had a poor outcome. Multivariate logistic regression analysis showed that severe WMHs was an independent risk factor for the occurrence of HT (odds ratio [ OR] 1.890, 95% confidence interval [ CI] 1.047-3.413; P=0.035) and poor outcomes ( OR 3.366, 95% CI 1.567-7.232; P=0.002) after reperfusion treatment in patients with AIS, but there was no independent correlation with sICH ( OR 8.403, 95% CI 0.891-79.294; P=0.063). Conclusion:Severe WMHs is an independent risk factor for the occurrence of HT and poor outcomes in patients with AIS after reperfusion treatment, but it has no independent correlation with sICH.

Objective:To investigate the correlations of collateral circulation with hemorrhagic transformation (HT) and short-term prognoses in patients with acute ischemic stroke (AIS) after different reperfusion therapies.Methods:Four hundred and forty-nine patients with AIS after different reperfusion therapies, admitted to our hospital from January 2016 to December 2019, were chosen in our study. These patients were divided into HT group ( n=90) and non-HT group ( n=359) according to whether HT presented or not. The baseline data, clinical characteristics, and prognoses of patients between the 2 groups were compared. And the variables of P<0.05 in univariate analysis were re-analyzed by multivariate Logistics regression to identify the independent influencing factors for HT in patients with AIS; the correlations between cerebral collateral circulation grading (American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology [ASITN/SIR], and modified Thrombolysis in Cerebral Infarction [mTICI]) and modified Rankin scale (mRS) scores at discharge were explored. Results:(1) There were significant differences between patients in the two groups in terms of age, percentages of patients with atrial fibrillation, baseline National Institutes of Health Stroke Scale (NIHSS) scores, emergency blood glucose, platelet count, and percentages of patients used dual antiplatelet agents and statin ( P<0.05). (2) Results of multivariate Logistics analysis: moderate stroke (NIHSS scores of 9-15), severe stroke (NIHSS scores≥16), elevated emergency glucose, atherosclerotic cerebral infarction and bridging therapy were independent risk factors for HT, and good collateral circulation status and dual antiplatelet therapy were independent protective factors for HT. (3) Correlation of collateral circulation with short-term prognosis: mRS scores of patients at discharge were negatively correlated with ASITN/SIR grading of collateral circulation and mTICI grading ( rs=-0.201, P=0.003; rs=-0.222, P=0.001). Further grouping by different reperfusion therapies showed that ASITN/SIR grading in the intravenous thrombolysis group and mTICI grading in the bridging therapy group were negatively correlated with mRS scores of these patients at discharge ( rs=-0.176, P=0.016; rs=-0.271, P=0.010). Conclusion:AIS patients with poor collateral circulation who receive reperfusion therapies are more likely to develop HT than patients with good collateral circulation, enjoying a relatively poor short-term prognosis.

Reperfusion therapy has become a standard treatment for acute ischemic stroke, which can effectively improve the outcomes of patients and reduce the mortality. Some studies have found that reperfusion therapy may increase the incidence of post-stroke seizures and post-stroke epilepsy, but this view is still controversial. This article reviews the recent studies on reperfusion therapy and post-stroke seizures and post-stroke epilepsy.

Objective To explore the influence of gender and age on auditory startle reflex in healthy adults.Methods A total of 150 healthy volunteers (92 males and 58 females) aged from 18 to 60 years were recruited for this study.A modified startle reflex paradigm was adopted.Furthermore,gender-age differences on startle magnitude,habituation,perceived spatial co-location induced prepulse inhibition (PSC-PPI) and perceived spatial separation-induced prepulse inhibition (PSS-PPI) in healthy volunteers were analyzed.Results ① There was no significant difference in amplitude and habituation of startie reflex between males and females (F=0.29,P=0.593;F=1.57,P=0.212).PSC-PPI and PSS-PPI were significantly higher in males (PSC-PPI:(34.68± 20.81) ％,PSS-PPI:(44.56 ± 23.19) ％) than those in females (PSC-PPI:(23.11±22.43)％,PSS-PPI:(35.21±25.09)％) (F=9.48,P=0.002;F=4.76,P=0.031).② There was a negative correlation between startle magnitude and age (r=-0.29,P＜0.01),however,no obvious correlations between age and PSC-PPI or PSS-PPI as well as habituation were observed.③Bivariate analysis of variance showed that no interaction between gender and age was found to the indexes of startle reflex(F=0.71-1.36,all P＞0.05).Conclusions There are differences for gender and age in the indexes of startle reflex.In detail,age chiefly influences startle magnitude,while gender mainly affects the prepulse inhibition.