Objective] To summarize the experiences of Professor Shu Qijin and to introduce his frequently used traditional Chinese medicine(TCM) herbal-pairs for treating lung cancer. [Methods] Professor Shu's experience and the treatment principles on herbal-pairs were summarized by attending the process of his diagnosis and treatment for lung cancer patients and his medical records. [Results] Shu treated that lung cancer by traditional Chinese medicine belongs to the multi-target therapy, drug although short, lung disease is also complex. However, the drug for lung cancer a target in strong, if properly combined, can hold simplification, observant insight. For advanced lung cancer patients with Qi deficiency symptoms, Shu used common heterophylla-Astragalus, Codonopsis-white atractylodes rhizome, Radix Glehniae, Ophiopogon japonicus, medicine of Fuzheng anticancer; sputum is a poison stasis, Shu divided common diffusa-sheliugu, Lobelia chinensis, Scutellaria barbata, Taxus chinensis var. mairei, Polygonum cuspidatum root medicine for detoxification Sanjie; blood stasis, Shu used common trigonous, rhizome, notoginseng, radix paeoniae rubra, etc. drug for promoting blood circulation and removing blood stasis. Anyway, Shu permited the treatment of lung cancer, on the basis of dialectical argumentation, discerning the pathogeny, disease location, disease, illness and mastering five flavors of the four properties of traditional Chinese medicine(TCM), rising and sinking, using the following drugs, clinical addition and subtraction, herbal prescription has better clinical efficacy, and attached with the case of a post-mortem. [Conclusions]Medicine of precise curative effect is determined by Shu and the mechanism of medication has higher clinical value,it is worth in-depth study and application.

Objective:By observing effects of Dahuang Zhechong Pills on CD44,VEGF and the metastasis suppressor in mice with Lewis Lung carcinoma,to discuss its mechanism of anti-tumor metastasis preliminarily.Methods:The mice were divided randomly into five groups the day after modeling and each group included ten mice.According to the pre-test,high-dose,medium-dose and low-dose were quantitated with 0.18g/ml,0.09 g/ml,0.045g/ml.The model group was intragastric administrated with NS 0.2ml for ten days;the chemotherapy group was Intraperitoneal administrated 50mg/kg CTX on the first day.Observing and numerating the pulmonary metastases with nodules by pulmonary pressure slide film on the 12th day.Based on immunohistochemical method to detect the expression of VEGF and the activity detection by flow cytometry CD44,Its anti-tumor mechanism and the role of target were preliminarily studied.Results:The inhibition rates of lung spontaneous metastasis in experimental groups of high(H),medium(M),low(L)dosages and the chemotherapy group were respectively 57.44 percent, 55.32 percent,38.72 percent,60.00 percent.CD44,respectively,values were 0.59?0.86,0.21?0.28,0.33?0.31,1.36?0.52; the experimental group(M)compared with model group,VEGF expression was significantly reduced,there was a significant difference(P0.05).Conclusion:Dahuang Zhechong Pills reduced the lung metastases incidence of C57BL mice with Lewis lung carcinoma and prolonged their lives.These results were obvious in the medium-dose experimental group.Medium-dose of Dahuang Zhechong Pills had effects on C57BL mice with Lewis lung carcinoma,whose CD44 activity were inhibited and the expression of VEGF was reduced.

[Objective]To explore the medication characteristics of Professor SHU Qijin,a renowned traditional Chinese medicine(TCM)practitioner in Zhejiang Province,in the treatment of primary liver carcinoma(PLC).[Methods]A comprehensive analysis was conducted on the characteristics of Professor SHU's differentiation and treatment of PLC,and Professor SHU's prescription medication for PLC patients were explored from the perspective of pathogenesis.[Results]The pathogenesis of PLC is complex,often based on liver depression and spleen deficiency,as well as organ Qi and blood deficiency.Prolonged illness,surgical operation,radiotherapy and chemotherapy can lead to Qi depletion and Yin damage,poor circulation of Qi and blood,obstruction of water and fluid metabolism,and subsequent endogenous evils such as Qi stagnation,blood stasis,water consumption,phlegm dampness and heat toxicity.Professor SHU often uses the method of soothing the liver and strengthening the spleen in clinical practice;strengthens medication for the related endogenous evil of"Qi,blood,and water"to slow down and eliminate the internal evil;pays attention to heat toxicity and use more heat clearing,detoxifying,and uses diuretic drugs to reduce tumor metastasis and recurrence;remembers to treat according to syndrome differentiation,strengthen the body resistance,strengthen the spleen,replenish Qi,and nourish Yin;combines modern pharmacology research of TCM and the theory of drug meridians,implements precise anti-cancer measures.[Conclusion]Professor SHU follows the method of clarifying the source and consolidating the root when diagnosing and treating PLC,adheres to the pathogenesis,focuses on syndrome types,regulates the circulation of Qi,blood,and water in the body,dispels pathogenic factors,clarifies the source,strengthens the body,uses precise medication,and provides comprehensive prescriptions to reduce the deterioration,metastasis,and recurrence of PLC.