Objective To evaluate the effect of low frequency ultrasound on the volume of the radiofrequency ablation lesion in canine hyperplasia prostate tissue.Methods A total of 9 experimental dogs were divided into three groups(3 in each group).Radiofrequency ablation was performed on the canine prostates.Low-frequency ultrasound was performed before the ablation of the experimental group.Radiofrequency ablation or low-frequency ultrasound was performed only in the control groups.Then all experiment animals underwent routine rectal examination,contrast-enhanced ultrasonography and MRI.The volume of prostate ablation lesions in enhanced magnetic resonance imaging was compared between the low-frequency ultrasound irradiation plus radiofrequency ablation group and the control group with radiofrequency ablation only.Statistical analysis was performed using the t-test to compare the differences between groups.Results Contrast enhanced ultrasonography(CEUS)performed immediately after low-frequency ultrasound irradiation showed that the time to peak of intra-prostatic contrast agent shortened,the maximum intensity decreased compared with those before irradiation [(28.55±10.88)s vs(14.81±5.15)s,t=2.796,P=0.0189],and the contrast agent duration increased [(2046.56±424.66)dB s vs(1454.82±458.12)dB s],the difference was statistically significant(t=2.32,P=0.0427).CEUS and MRI can accurately evaluate the size of the prostate radiofrequency ablation.The ablation volume of the experimental group after ablation was(1.27 ± 0.21)cm3in the experimental group,while the volume of the ablation group in the control group was(0.73±0.18)cm3,and the difference was statistically significant(t=3.382,P=0.0277); however,the other group which were only exposed to low-frequency ultrasound did not show lesions.Conclusion Low frequency ultrasound irradiation can effectively block the blood flow in proliferative prostatic tissue,and combined with radiofrequency ablation can effectively increase the volume of ablation.

BackgroundWomen may develop severe symptoms of stress disorder following childbirth， which may be exposed to a risk of developing mental health problems， and even lead to the recurrence of the illness in female patients with schizophrenia， while comparatively limited research has been undertaken concerning the clinical characteristics and treatment of puerperal schizophrenia in China. ObjectiveTo explore the clinical characteristics of puerperal schizophrenia， so as to provide references for the clinical treatment. MethodsA total of 24 patients with puerperal schizophrenia who were hospitalized in the female ward of adult psychiatry department of the Affiliated Brain Hospital of Guangzhou Medical University from 2012 to 2020 and met the Diagnostic and Statistical Manual of Mental Disorders， fourth edition （DSM-IV） diagnostic criteria for schizophrenia were included as puerperal group. Another 48 non-puerperal women with schizophrenia were concurrently enrolled as control group. Then the basic data， scores on Positive and Negative Symptom Scale （PANSS） and the discharge medication were recorded. ResultsThe percentages of newly onset and positive family history of psychosis in puerperal group were larger than those in control group， with statistical significance （χ²=9.321， 5.240， P<0.05 or 0.01）. Puerperal group scored higher on PANSS excitement factor （t=-2.220， P<0.05） and lower on negative factor （t=3.377， P<0.01） compared with control group. In terms of discharge medication， puerperal group reported a higher dosage of antipsychotic drugs （t=-2.095， P<0.05）， and a larger proportion of combined use of benzodiazepines or antidepressants （χ²=21.316， 5.114， P<0.05 or 0.01） compared with control group， with statistical significance. ConclusionPatients with puerperal schizophrenia display increased ratings of excitement symptoms and decreased ratings of negative symptoms， which necessitates the use of high doses of antipsychotic drugs， and combined use of benzodiazepines and antidepressants.