OBJECTIVETo prepare ginkgo biloba extract (GBE) sustained-release tablets and observe its in vitro release profile.

METHODGBE sustained-release tablets were prepared by direct compression method using sodium carboxymethylcellulose (CMC-Na) and hydroxypropyl methylcellulose HPMC) as matrix excipients. Based on the result of single-factor selecting experiment, the formulations and preparation process were optimized through orthogonal design, and release difference of tablets was evaluated with similarity factor (f2).

RESULTThe ratio of HPMC and CMC-Na, the viscosity of HPMC and the different types of the diluents had pronounced effect on the release of GBE sustained release tablets, although the hardness and weight difference of tablets did not show notable influences.

CONCLUSIONGBE sustained-release tablets that prepared by using the mixture of HPMC and CMC-Na display constant release profile in 12 h.

Delayed-Action Preparations ; chemistry ; Drug Compounding ; methods ; Drug Stability ; Ginkgo biloba ; chemistry ; Plant Extracts ; chemistry ; Tablets ; chemistry

In this paper , 2280 strains of suspicious Shigella c culture were detected by the diagnostic typing phage set for Enterobacteriaceae, the routine identification of them were carried oat at the same time . The results showed that 100% of shigella cultures were lysed with 10~3RTD and 99.9% lysed with 1RTD of phage Sh. 12.3% of 65 non-shigeUa cultures agglutinating with typing serum of shigeUa was lysed with 10~3RTD, 4.6% lysed with 1RTD of phage Sh. The determination of lytic-pattern of 2215 shigella culture indicated that only 3 strains of Boyd 5 of lytic-pattern 3 were not reported in literature, the rest strains were consistent to fomer studies. The nonshigella cultures lysed by Sh 10~3RTD could be excluded with 1RTD and its lytic-pattern. 20 strains of Enteroinvasive Escherichia coli possessing shigeUa-related antigens could be differentiated by Sh 10~3RTD. 1RTD and its lytic-pattern.

OBJECTIVETo prepare paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD) loaded colon-specific release tablets.

METHODThe core tablets were prepared with the mixture of Pae-beta-CYD inclusion complex, peotin and calcium acetate, and coated with ethanolic solution of Eudragit S100. The effects of coating weight, amount of plasticizer, curing time and temperature on the release of drug from tablets were investigated in vitro.

RESULTAbout 5-6 h retarded release of paeonol in the dissolution media of pectinase or rats colon contents were obtained by 12% coating weight gain and 20% Dibutyl phthalate (DBP) was used as plasticizer, and subsequently curing the tablets at 45 degrees C for 12 h.

CONCLUSIONPae-beta-CYD loaded colon-specific release tablets showed pH environment and enzyme dependant release properties.

Acetophenones ; pharmacokinetics ; therapeutic use ; Animals ; Colitis, Ulcerative ; drug therapy ; Colon ; drug effects ; Drug Delivery Systems ; methods ; Excipients ; chemistry ; Humans ; Hydrogen-Ion Concentration ; Rats ; Rats, Sprague-Dawley ; Tablets, Enteric-Coated ; chemistry ; beta-Cyclodextrins ; chemistry