Chemotherapy has been widely used in treating patients with colorectal cancer(CRC).Despite the tremendous progress achieved in cancer treatment during the last decades, drug resistance remains a major obstacle to effective treatment for CRC. Emerging evidence shows that microRNAs (miRNAs) play an important role in regulating the drug sensitivity of tumor cells. This review aimed to summarize the association of microRNA expression with chemotherapy in colorectal cancer.

Purpose: To analyze the treatment effects by radiotherapy alone and radiotherapy plus chemotherapy of carotid artery intubation after operation for malignant astrocytoma. Materials and Methods: 135 patients with malignant astrocytoma were treated from August, 1987 to November, 1992. Patients were divided into two groups after operation: 71 patients received radiotherapy alone and 64 patients,combination therapy of chemotherapy (BCNU) plus radiotherapy. All patients received DT 55～70Gy. In combination therapy group, BCNU(250mg) was given daily by carotid artery intubation for 4～15 days.Radiotherapy was given 10～15 days after chemotherapy, then followed by 1～3 intubation. Results: The median survival were 17.5 months in radiotherapy alone group and 31.9 months in combination one.Patients with glioblastoma gave the better results with the 2-,3-,and 5- year survivals of 70%, 36% and 15%, respectively. Conclusion: Chemotherapy (BCNU) of intubation plus radiotherapy is preferable in treating malignant astrocytoma after operation.

Objective To improve the therapeutic response and survival of locally advanced pancreatic cancer treated with radiochemotherapy. Methods Fifty nine patients with stage Ⅱ Ⅲ pancreatic cancer were divided into two groups: 33 patients were treated with three dimensional conformal radiotherapy (3DCRT) plus regional intra arterial infusion chemotherapy (CT)and 26 patients received 3DCRT alone.Results The response (pain alleviating) rates were 78.8% in 3DCRT+CT group and 80.8% in 3DCRT group,while the overall response (CR+PR) rates were 78.8% and 42.3% (P