Objective:To explore the effects of Xiao's double-C nursing mode based on enhanced recovery after surgery (ERAS) on perioperative related indexes and pain in patients undergoing mixed hemorrhoid surgery.Methods:From August 2019 to August 2020, 60 patients undergoing mixed hemorrhoid surgery who were admitted to anorectal surgery department of Anqing Municipal Hospital were enrolled as the research objects by single center, random, single blind and parallel control methods. They were divided into control group (routine perioperative nursing) and observation group (ERAS-based Xiao's double-C nursing mode) by random number table method, 30 cases in each group. The perioperative indexes, scores of postoperative Visual Analogue Scale (VAS) and wound healing, postoperative complications and nursing satisfaction were compared between the two groups.Results:The first urination time, defecation time, hospitalization time and hospitalization cost were (5.78±1.38) h, (13.37±2.38) h, (7.32±0.72) d and (7 337.84±524.99) yuan in the observation group, and (6.48±1.26) h, (16.72±2.33) h, (8.85±0.93) d, (8 689.54±688.34) yuan in the control group, and the differences were statistically significant ( t values were 2.052-8.552, P<0.01 or 0.05). There were between-group, time and interaction differences in the scores of VAS and postoperative wound healing between the two groups ( Fbetween-group values were 36.24, 42.36, Ftime values were 256.71, 377.42, Finteraction values were 88.62,90.62, P<0.01). There was no significant difference in the incidence of postoperative complications between the two groups ( P>0.05). The scores of nursing satisfaction with health education and services accessibility were (94.37±2.92), (95.11±3.85) points in the observation group, and (92.38±3.01), (91.72±4.31) points in the control group, and the differences were statistically significant ( t values were 2.599, 3.213, P<0.05). Conclusions:ERAS-based Xiao's double-C nursing mode is beneficial to shorten first defecation time, incision healing time and hospitalization time of patients undergoing mixed hemorrhoid surgery, accelerate wound healing and alleviate pain, with higher nursing satisfaction.