Objective To compare the diagnostic accuracy between neutrophil CD64 and C-reactive protein (CRP) as a single test for the early detection of neonatal sepsis. Methods A total of 36 patients who were hospitalized in neonatal intensive care unit (NICU) in our hospital were divided into documented sepsis group(n=10), clinical sepsis group (n=14) and control newborns (n=12). CRP, neutrophil CD64, complete blood counts and blood culture were detected at the time of the suspected sepsis for the documented or clinical group. CD64 was measured by automatic flow cytometry. The di-agnostic value of CRP and CD64 was assessed by receiver operating characteristic (ROC) curve analysis. Results CD64 was significantly elevated in the groups with documented or clinical sepsis, whereas CRP was not significantly increased compared with controls. For documented sepsis group, CD64 and CRP had a sensitivity of 92% and11%, a specificity of 83% and 80%, a positive predictive value of 83% and 34% and a negative predictive value of 91% and 50%, respectively, with a cutoff value of 3.2 mg/dL for CD64 and 1.1 mg/dL for CRP. Conclusion The diagnostic ac-curacy of CD64 is superior to CRP when measured at the time of suspected sepsis, which implies that CD64 is a more reliable marker for the early identification of neonatal sepsis as a single determination compared with CRP.

Objective:To explore the short-term outcomes of dual kidney transplantation and summarize its safety and feasibility.Methods:From September 2018 to September 2019, a total of 7 dual kidney transplantations were performed. And retrospective analysis was performed for baseline profiles, clinical data and postoperative complications.Results:The mean age was (62.7±8.5) years for donors and (43.9±9.3) years for recipients. The Remuzzi score of 6 paired kidneys ranged from 4 to 6 points. During follow-ups, the survival rate of 7 dual kidney transplantation grafts and recipients was 100%. The median follow-up period was 16 months. Renal function of 6 recipients normalized within 1 week and delayed graft function (DGF) occurred in one case. All of them underwent unilateral kidney transplantation with an average operative duration of (5.6±1.4) hours. There was no onset of operative complications. One case of rejection was not confirmed by biopsy. Among three patients of lung infections, there was one case of severe pneumonia. In 3 cases, lateral plasma flow of transplanted kidney exceeded that of medial plasma flow.Conclusions:Dual kidney transplantation in adults is both safe and feasible so as to expand the availability of donated kidney.