1. Clinical-pathologic features and outcomes of IgA nephropathy patients with IgM deposition
Qice SUN ; Dongrong YU ; Hongyu CHENG ; Bin ZHU ; Yunqin HU ; Fei JIANG ; Jun WU ; Yongjun WANG
Chinese Journal of Nephrology 2017;33(1):8-14
Objective:
To determine the correlation of IgM deposition with clinic-pathological features and outcomes of IgA nephropathy patients.
Methods:
A total of 1060 patients, who were diagnosed as IgA nephropathy by renal biopsies between 2001 and 2007 in Guangxing Hospital were enrolled. According to immunofluorescent test, patients were divided into patients with mesangial IgM deposition and patients without IgM deposition. Renal survival curves were assessed by Kaplan-Meier method. The effect of IgM deposition on outcomes of IgA nephropathy patients was examined by univariate and multivariable Cox proportional-hazards regression.
Results:
Among 1060 IgA nephropathy patients, there were 750 patients with IgM deposition and 310 patients without IgM deposition. (1) Urinary protein and uric acid in patients with IgM deposition were significantly higher than those in patients without IgM deposition (all