Objective To explore the clinical value of serological indicators in diagnosis of patients with different degree of liver cirrhosis.Methods 50 patients with liver cirrhosis and 50 patients with decompensate cirrhosis were selected.The control group had 50 patients.The serological indicators were statistically analyzed.Results TBIL and ALT in the decompensated liver cirrhosis group were (69.5 ± 7.0) μmol/L,(143.1 ± 14.2) U/L,which were higher than those of compensated liver cirrhosis group (44.6 ± 5.8) μmol/L,(77.4 ± 8.6) U/L (P ＜ 0.05),and those two groups were higher than the control group(P ＜ 0.05).Alb and ChE of decompensated liver cirrhosis group were (28.2 ± 3.7) g/L and (2024.39 ± 211.40) U/L,which were lower than those of the control group (36.1 ±3.7) g/L,(6169.36 ± 607.42) U/L and the compensated cirrhosis group [(34.7 ± 4.3) g/L,(3571.27 ± 310.01)U/L] (P ＜0.05).ChE of compensated cirrhosis group was lower than the control group (P ＜0.05).PA and ADA of decompensated and compensated liver cirrhosis group were (0.14 ±0.04)mg/L,(16.17 ± 1.94)U/L and (0.21 ±0.05) mg/L,(34.20 ± 3.29) U/L,the differences were statistically significant (P ＜ 0.05).A/G of decompensated and compensated liver cirrhosis group were (0.64 ± 0.29) and (1.06 ± 0.30),which were lower than the control group (1.51 ± 0.21) (P ＜ 0.05),and that of the decompensated cirrhosis group was lower than that of the compensated cirrhosis group(P ＜0.05).Ⅳ-C and LN of decompensated cirrhosis group were (97.4 ±9.8) μg/L and (205.7 ±20.1) μg/L,which were higher than those of compensated liver cirrhosis group (68.7 ± 7.5) μg/L and (124.1 ±11.8) μg/L and the control group(52.3 ±6.1) μg/L and (83.8 ±7.6) μg/L(P ＜0.05).And those of the compensated cirrhosis group were higher than the control group (P ＜ 0.05).HA and PC Ⅲ of decompensated cirrhosis group were (211.3 ± 16.4) μg/L and (168.1 ± 16.2) μg/L,which were higher than the control group (51.2 ±5.3) μg/Land (79.1 ± 8.0) μg/L (P ＜ 0.05).Conclusion The serological indicators had the important reference value for clinical diagnosis and prognosis of cirrhosis.