1.The effect ofTanreqing injection combined with conventional western medicine therapy on children with bronchioliti
Zhuxing FENG ; Xinqi LI ; Qiaorong LI
International Journal of Traditional Chinese Medicine 2016;38(6):515-518
Objective To detect the effect ofTanreqing injection combined with conventional western medicine therapy on children with bronchioliti.Methods A total of 116 children with bronchioliti were enrolled in this study. Children were randomly divided into the control group (n=58) andTanreqing injection observation group (n=58). The control group received continued low flow oxygen, anti-infection treatment, and salbutamol aerosol to relieve asthma. The observation group receivedTanreqing injection based on the intervention of control group. Each group was treated for 7 d. The Th17 and Treg cells were detected by cytometry analysis and the expression of IL-17 and IL-10 were detected by ELISA analysis. The clinical effect of the two groups was compared.Results After treatment, compared with the control group, the Th17 cells (5.91% ± 0.83%vs. 7.23% ± 1.25%,t=2.346) and IL-17 (14.62 ± 3.24 ng/mlvs. 22.52 ± 5.14 ng/ml,t=2.412) decreased significantly, and the Treg cells (7.32% ± 1.24%vs. 5.32% ± 1.03%,t=2.352) and IL-10 (15.84 ± 2.23 ng/mlvs.11.72 ± 2.12 ng/ml,t=2.365) increased significantly in the observation group (P<0.05). The temperature recovery time (t=2.264,P=0.048), disappearance time of coughing (t=2.437,P=3.406), wheezing(t=2.258,P=2.352), pulmonary rales (t=0.032,P=0.034) and hospital duration (t=0.046,P=0.042) in the control group were significantly higher than those in the observation group. The clinical effective rate (94.8%, 55/58) in observation group was higher than that (79.3%, 46/58) in control group (χ2=2.327,P=0.041). ConclusionTanreqing injection can regulate Th17/Treg cell balance, and its curative effect is superior to conventional therapy in children with bronchiolitis.
2.Inhibitory effects of IBI302 on experimental choroidal neovascularization
Yuliang FENG ; Ming ZHANG ; Chunming WANG ; Jia LI ; Qiaorong DAN
Chinese Journal of Ocular Fundus Diseases 2016;32(2):177-183
Objective To investigate the inhibitory effects of IBI302 on experimental choroidal neovascularization (CNV).Methods Affinity of IBI302 to vascular endothelial growth factor (VEGF) family cytokines (including VEGF-A165,VEGF-A121 and placental growth factor PlGF) and complements (C3b,C4b) was determined by enzyme-linked immunosorbent assay (ELISA).The antagonist effect of IBI302 on VEGF was measured by proliferation,migration and tube formation tests of human umbilical vein endothelial cells (HUVEC).The anti-complement activity of IBI302 was measured by hemolysis test mediated by complement classical pathway and alternative pathway.Rhesus laser-induced CNV model was divided into 5 groups including model control group,bevacizumab group,IBI302 0.25 mg group,IBI302 0.50 mg group and IBI302 1.25 mg group.Fluorescein angiography and optical coherence tomography were performed on these monkeys at 14 and 28 days after drug delivery to observe the fluorescein leakage area and retinal thickness.The aqueous VEGF concentration was measured at 29 days after drug delivery.Results IBI302 showed good affinity to VEGF-A165,VEGF-A121 and PlGF,as well as C3b and C4b.IBI302 significantly inhibited the proliferation,migration and tube formation of HUVEC induced by VEGF-A165.IBI302 inhibited the hemolysis induced by complements obviously.At 14 and 28 days after drug delivery,the area of fluorescein leakage and retinal thickness in IBI302 0.25 mg group,IBI302 0.50 mg group,IBI302 1.25 mg group were reduced.The differences of the area of fluorescein leakage and retinal thickness in three IBI302 groups were not significant (P>0.05).At 29 days after drug delivery,the VEGF concentration in the aqueous of rhesus monkey in bevacizumab group [(38.644 ± 6.521) pg/ml] was decreased than that in model control group [(94.203± 17.360) pg/ml],the difference was significant (P< 0.05).The VEGF concentration in the aqueous of rhesus monkey in three IBI302 groups were less than 31.300 pg/ml.Conclusion IBI302 inhibited experimental CNV through blocking the activity of VEGF and complement.
3.The effect of improved epidural catheter labor analgesia on the maternal and infant outcome of re-pregnant parturients with scar uterus
Ruixin ZHAO ; Yanmin SHEN ; Qiaorong FENG
Chinese Journal of Postgraduates of Medicine 2022;45(6):514-517
Objective:To investigate the effect of improved epidural catheter labor analgesia on the maternal and infant outcome of re-pregnant parturients with scar uterus.Method:A total of 100 cases of re-pregnant women with scarred uterus admitted to Shexian Hospital from January 2019 to January 2020 were selected. According to the random number table, they were divided into the observation group (50 cases) and the control group (50 cases). Parturients in the observation group received a modified epidural catheter for labor analgesia, and parturients in the control group received conventional epidural analgesia. The complications of epidural vascular injury, difficulty in catheterization, multiple catheterization, loss of catheter resistance, urinary retention, intrauterine distress, neonatal asphyxia, postpartum hemorrhage, Apgar score, maternal and neonatal outcomes were compared between the two groups.Results:The rate of epidural vascular injury, difficulty in catheter placement, multiple catheter placement and disappearance of catheter resistancein the observation group were lower than those in the control group: 2.0%(1/50) vs. 14.0%(7/50), 2.0%(1/50) vs. 16.0%(8/50), 0 vs. 8.0% (4/50), 8.0% (4/50) vs. 24.0% (12/50), χ2 = 4.89, 5.98, 4.17, 4.76, P<0.05. The rate of urinary retention, intrauterine distress and neonatal asphyxia in the observation group were lower than those in the control group: 4.0%(2/50) vs. 16.0%(8/50), 2.0%(1/50) vs. 14.0%(7/50), 0 vs. 8.0%(4/50), χ2 = 4.00, 4.89, 4.17, P<0.05. Conclusions:Improved epidural catheter delivery analgesia for patients with scarred uterus can achieve significant results, effectively reduce the incidence of vascular injury, and improve the maternal and infant outcome.
4.Efficiency and safety of Hydromorphone combined with Propofol therapy in painless gastroscopy combined with colonoscopy examination in elder patients
Zhen ZHANG ; Meng GAO ; Qiaorong DENG ; Xilong LI ; Yaping CUI ; Aimin FENG ; Shuanshuang HE ; Xihua LU
Chinese Journal of Geriatrics 2017;36(11):1224-1228
Objective To explore the clinical efficacy and safety of Hydromorphone combined with Propofol therapy in painless gastroscopy combined with colonoscopy examination in elder patients.Methods Sixty-one patients aged 65-80 years underwent a painless gastroscopy combined with colonoscopy examination in the Affiliated Tumor Hospital of Zhengzhou University from June 2015 to January 2016.The patients were randomly divided into the Hydromorphone combined with Propofol group (Group H,n=31) and the Fentanyl combined with propofol group (Group F,n=30).Results The levels (H vs F group) of VAS at 5,15,30 min after anesthetic recovery were lower in H group thanin F group[(2.4±0.5) vs (3.4±0.6),(2.0±0.5) vs (3.2±0.6),(1.6±0.4) vs (2.6±0.7) respectively,(all P<0.05)],and those of ramsay sedation scores at 5,15,30,45,and 60 min after anesthetic recovery were lower in H group than in F group[(2.6 ± 0.4) vs (3.3 ± 0.5),(2.3±0.5) vs (2.9±0.4),(2.1±0.3) vs (2.6±0.3),(1.9±0.3) vs (2.2±0.3),(1.8±0.3) vs (2.0±0.3) (all P<0.05)] respectively.Additionally,the incidence rates (H vs F group) of nausea and vomit (3.2% vs.26.7%),respiratory depression (0.0% vs.33.3%) and restlessness (6.5% vs.30.0%) within 60 min after anesthetic recovery were lower in the group H than in the group F (all P< 0.05).However,there were no statistical differences in the indexes of postoperative gastrointestinal function between two groups (all P>0.05).Conclusions The clinical efficiency of hydromorphone combined with propofol used in painless gastroscopy combined colonoscopy examination is favourable and safe without increasing postoperative adverse reactions in elder patients.Hydromorphone combined with propofol is superior to fentanyl combined with propofol as a general intravenous anesthesia.
5.Ethnic differences in the association of hypertension duration with cardiovascular diseases risk in Chinese adults.
Leilei LIU ; Zixuan XU ; Linyuan ZHANG ; Xiao ZHANG ; Cailiang ZHANG ; Zixiu QIN ; Jing HUANG ; Qianyuan YANG ; Jun YANG ; Xuejie TANG ; Qiaorong WANG ; Feng HONG
Chinese Medical Journal 2023;136(15):1882-1884