With the popularity of heart disease and obesity,as an important part of the integrated management of heart disease,weight gradually attracting attention from all walks of life.This paper summarizes the 2013 to 2016,American College of Cardiology/American Heart Association (ACC/AHA) jointly launched by the obese patients lose weight guide and aimed at overweight or obese patients with the fone management based on the weight of the specific steps,and by the AHA and international diabetes groups put forward the treatment of type 2 diabetes and overweight or obesity surgery.

On June 20,2014 in Washington for a meeting of the heart,a think-tank.As a call to action,the meeting to define the cardiovascular disease~ prevention and control of new mode and method,to help solve the problem of merging high metabolic risk of cardiovascular disease.More than 20 representative groups participate in the discussion and meet the following consensus that metabolic syndrome is a complex pathophysiological state,is a process of gradual change,consisting of a series of known and unknown risk factors,and is associated with the severity of the disease.Treatment is the ideal mode of the metabolic syndrome,before the disease can accurately determine risk,identify the subtypes of disease,and identify the different stages of the disease,in order to better carry out prevention and treatment of cardiovascular disease.This new mode of prevention and control of determination needs establishment of consensus,and sustainable development of this control mode,the mode of authentication,in the future continue to optimize the mode.

Atherosclerosis is a kind of participation of multiple factors,complicated chronic lesions.It has become a threat to people's life and health,with the deepening of the research,this paper summarizes the risk factors of the newly discovered in recent years,with the risk factors causing atherosclerosis for more targeted prevention and control measures.

Aim To explore the effect of high density lipoprotein and apolipoprotein A-I mimetic peptide on the secretion and the expression of adiponectin in fully differentiated 3T3-L1 adipocytes in inflammatory status and the possible mechanism.Methods Fully differentiated 3T3-L1 adipocytes were incubated in the medium containing various concentrations of high density lipoprotein(10~100 mg?L-1) and apolipoprotein A-I mimetic peptide(1~50 mg?L-1)with 100 ?g?L-1 lipopolysaccharide(n=3).Evaluate the levels of adiponectin in supernatant,the mRNA expression of adiponectin and PPAR?,and the activity of NF-?B.Results During LPS stimulation adiponectin concentrations in supernatant decreased from 0.25?0.03 ?g?L-1 to 0.14?0.02 ?g?L-1(P

3T3-L1 adipocytes were cultured with various concentrations of high-density lipoprotein ( HDL, 0, 10, 50, and 100 μg/ml ) for 16 h and with lipopolysaccharide ( LPS, 100 ng/ml ) for another 6 h. Interleukin-8 in the medium was determined by ELISA, and PPAR-γ mRNA expression by reverse transacription polymerase chain reaction (RT-PCR). Interleukin-8 levels were increased in LPS-treated cells ( P＜0.05 ), but decreased in HDL-treated cells in the dose-dependent manner. PPARγ mRNA expressions were increased in HDL-treated groups than those treated only with LPS. These results suggested HDL may decrease interleukin-8 secretion via up-regulating PPARγ expression in adipocytes.