Background Triamcinolone acetonide (TA) is often used in the treatment of uveitis and fundus disease,but whether it has toxic effect to normal tissue around eyes is unclear.Objective The aim of this study was to explore the adverse and toxic effects of TA on the periorbitally normal tissue following the periocular injection.Methods Twenty-seven New Zealand albino rabbits were randomly divided into experimental group,normal saline solution group and blank control group.TA was periocularly injected twice (20 mg for each) at 1-month interval in the rabbits of the experimental group,and 0.5 ml normal saline solution was used in the same way in the rabbits of the normal saline solution group.Not any drug was used in the blank group.The rabbits were sacrificed 1 month and 2 months,3 months after the secondary injection.For the preparation of the specimens of extraocular muscles,peribulbus adipose tissue,lacrimal gland and optic nerve.Hematoxylin and eosin staining of the specimens was performed to examine the the pathological change under the optical microscope,and the ultrastructural of peribulbus tissues was observed under the transmission electron microscope.Results No statistically significant change was found in IOP among various time points and groups (Fgroup =0.952,P =0.881 ; Ftime =7.297,P =0.411).The hyphological structures and ultrastructure of extraocular muscles,peribulbus adipose tissue,lacrimal gland and optic nerve were normal in the rabbits of the normal saline solution group and the blank control group.However,the optical microscopy showed varying degrees of atrophy or dissolving in the extraocular muscle fibers,the increase of glandular epithelial cells and enlargement of nuclei in the lacrimal gland as well as visible disorder arrangement of nerve fibers,vacuoles degeneration and the decrease of glial cells in optial nerve tissue in the rabbits of the experimental group from 1 month though 3 months after the secondary injection.Under the transmission electron microscope,the muscle stripes,bright band and dark band were incompletely disappeared,and expansionary sarcoplasmic reticulum and oval nucleus at the inferior to sarolemma were seen in the extraocular muscles.In addition,swelling lacrimal gland epithelial cells,thickening nuclear membrane and more organelles were exhibited in the lacrimal gland.In the optic never tissue,uneven myelin,space between axons and myelin,lamellar separation and degeneration also were revealed in the rabbits of the experimental group after injection of TA.Peribulbus adipose tissue was near normal both by optical microscope and transmission electron microscope in the experimental group.Conclusions The periocular injection of TA dose not elevated the IOP.However,it will result in the histogical and ultrastructural damages of extraocular muscles,lacrimal gland and optic nerve.

Objective To observe the international obstetric services model to reduce the incidence of hypoxic ischemic encephalopathy( HIE) in natural childbirth neonatal. Methods A total of 360 maternals from February 2012 to May 2014 were selected, according to production inspection manual number, odd as the study group and even as the control group, 180 cases in each group. The study group adopts the scheme of new international obstetrics service mode, the control group used traditional obstetric services model. Rate of maternal natural childbirth, maternal satisfaction and incidence of HIE were compared between the two groups. Results The rate of childbirth maternal natural and satisfaction of the observation group were 88. 5%, 96. 0%, which were significantly higher than that of the control group (χ2 =6. 632, 4. 114,P<0. 05). Incidence of HIE in the observation group was 4. 19%, which was significantly lower than 10. 14% in the control group, the difference was statistically significant (χ2 =4. 267,P <0. 05). Conclusions International obstetric service mode can reduce the incidence of HIE in natural childbirth neonatal, which has a high value of popularization.

Objective To investigate the influence of facial acne on the quality of life in college students.Methods The Quality of Life-Acne ( QOL-Acne) designed by Martin AR, the questionnaire of self-assessment on patients ’ severity and self-designed epidemiological questionnaire were used to investigate and analyze the quality of life in college students in order to explore the risk factors that affecting college students’ quality of life.Results The results of single factor Logistic regression analysis suggested that the risk factors affecting quality of life were gender, course of disease, clinical severity, self-assessment severity.The results of multi-factor Logistic regression analysis suggested that gender (β=-0.667,OR=0.475) and self-assessment severity (β=-0.713, OR=0.534) were significantly associated with the quality of life in college students. Conclusions The facial acne can make greater influence on female students than male college students.The gender of college students and self-assessment severity are the risk factors affecting their quality of life.It is necessary for medical staff to carry out the related health education on facial acne in hospitals and at schools.