Objective:To observe the effect of magnesium sulfate combined with nifedipine on preeclampsia blood pressure and pregnancy outcomes. Methods:The data of 62 patients with preeclampsia were retrospectively studied. According to the treatment reg-imen, the patients were divided into the control group (30 cases) with magnesium sulfate treatment and the observation group (32 ca-ses) with magnesium sulfate combined with nifedipine treatment. The blood pressure before and after the treatment, as well as the clin-ical efficacy, pregnancy complications and pregnancy outcomes in the two groups were compared. Results:After the treatment, systolic and diastolic blood pressure of the patients in the two groups were significantly lowered when compared with those before the treatment (P<0. 05), and the decrease in the observation group was more significant than that in the control group (P<0. 05). The total effec-tive rate of the observation group was 96. 88%, which was significantly higher than that of the control group (73. 33%, P<0. 05). The incidence of uterine inertia, postpartum hemorrhage, fetal distress and placental abruption in the observation group was significant-ly lower than that in the control group (P<0. 05), and the rate of cesarean section and neonatal asphyxia in the observation group was also significantly lower than that in the control group(P<0. 05). Conclusion:Magnesium sulfate combined with nifedipine in the treat-ment of preeclampsia shows notable antihypertensive effect, which can reduce the incidence of pregnancy complications and adverse pregnancy outcomes. Therefore, the combination exhibits better efficacy than magnesium sulfate alone.

Objective To evaluate the effects of low blood sugar production index (LGI) combined with low blood sugar production burden (LGL) dietary intervention on blood glucose, oxidative stress and anthropometric indicators in type 2 diabetes mellitus. Methods A total of 150 cases of type 2 diabetes were randomly divided into two groups,maintain the original treatment plan of two groups,75 patients in the control group were given traditional food interchange method for dietary intervention;the experimental group of 75 patients, provide food education based on LGI+LGI food exchange method , the time period of 3 months. Fasting blood glucose (FPG)、2h postprandial blood glucose (2hPG), Glycated hemoglobin (HbAlc), Superoxide dismutase (SOD), Malondialdehyde (MDA), Vitamin C, Vitamin E, Body Mass Index (BMI), Waist circumference (WC) Upper arm muscle circumference (AMC), Triceps skin fold thickness (TSF) were observed before and after the intervention. Results There were no significant differences in blood glucose, oxidative stress and anthropometry between the two groups (P>0.05). After intervention, in the control group: FPG, 2hPG, HbAlc, SOD, MDA, Vitamin C, Vitamin E, BMI, WC, AMC, TSF were (10.27 ± 2.67) mmol/L, (11.51 ± 2.54) mmol/L, (8.78 ± 1.95)%, (322.73 ± 51.97) kU/L, (5.80 ± 1.76)μmol/L, (40.78±4.86)μmol/L, (19.33±4.79)μmol/L, (23.94±3.18) kg/m2, (89.57±10.23) cm, (24.10± 3.01) cm, (18.38 ± 3.79)mm respectively. In the experimental group: they were (8.76 ± 2.77) mmol/L, (10.63 ± 1.76) mmol/L, (7.96 ± 1.86)%, (357.29 ± 60.04) kU/L, (5.26 ± 1.33)μmol/L, (44.01 ± 7.06)μmol/L, (21.58 ± 5.25) μmol/L, (22.93 ± 2.75) kg/m2, (86.05 ± 10.79) cm, (22.75 ± 2.86) cm, (16.98 ± 4.48) mm respectively. There was significant difference between the two groups after intervention (t=2.049-3.769, all P < 0.05). In the experimental group, the improvement of blood sugar, oxidative stress and anthropometry was better than that of the control group (P < 0.05). Conclusions LGI combined with LGL diet intervention is better than the traditional method of food interchange, the blood glucose, oxidative stress and anthropometric indicators have improved, which can improve treatment efficacy in type 2 diabetes and easy for home self-management.