1.Wolffian adnexal tumor: report of a case.
Ren-qiao LIU ; Zhen-huan ZHANG ; Min-hong PAN ; Zhi-hong ZHANG ; Qin-he FAN
Chinese Journal of Pathology 2013;42(7):476-477
Adenoma
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metabolism
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pathology
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surgery
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ultrastructure
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Adnexa Uteri
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pathology
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surgery
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Adnexal Diseases
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metabolism
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pathology
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surgery
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Carcinoma, Endometrioid
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metabolism
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pathology
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Diagnosis, Differential
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Female
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Granulosa Cell Tumor
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metabolism
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pathology
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Humans
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Hysterectomy
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Keratins
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metabolism
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Leiomyomatosis
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pathology
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surgery
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Microscopy, Electron
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Middle Aged
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Neoplasms, Multiple Primary
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metabolism
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pathology
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surgery
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ultrastructure
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Sertoli-Leydig Cell Tumor
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metabolism
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pathology
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Uterine Neoplasms
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pathology
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surgery
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Vimentin
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metabolism
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WT1 Proteins
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metabolism
3.Qualitative analysis of chemical constituents in Si-Wu Decoction based on TCM component database.
Zhen-fang WANG ; Yang ZHAO ; Zi-quan FAN ; Li-ping KANG ; Li-rui QIAO ; Jie ZHANG ; Yue GAO ; Bai-ping MA
Acta Pharmaceutica Sinica 2015;50(10):1309-1317
In order to clarify the chemical constituents of Si-Wu Decoction rapidly and holistically, we analyzed the ethanol extract of Si-Wu Decoction by UPLC/Q-TOF-MSE and UNIFI which based on traditional Chinese medicine database, the probable structures of 113 compounds were identified. The results show that this method can rapidly and effectively characterize the chemical compounds of Si-Wu Decoction and provide a new solution for identification of components from complex TCM extract.
Chromatography, High Pressure Liquid
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Databases, Pharmaceutical
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Drugs, Chinese Herbal
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chemistry
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Medicine, Chinese Traditional
4. Diagnostic value of 11C-methionine PET/CT imaging for detecting the recurrence of supratentorial glioma
Zhen QIAO ; Xiaobin ZHAO ; Qian CHEN ; Kai WANG ; Di FAN ; Lin AI
Chinese Journal of Nuclear Medicine and Molecular Imaging 2019;39(11):647-652
Objective:
To assess the diagnostic values of 11C-methionine (MET) PET/CT semiquantitative parameters for detecting recurrence in patients who were diagnosed with suspicious recurrence by MRI after resection of supratentorial gliomas.
Methods:
A total of 164 patients (107 males, 57 females, age 6-74 years; high-grade 94, low-grade 63, unclear 7) with supratentorial gliomas who underwent 11C-MET PET/CT between June 2015 and June 2017 in Beijing Tiantan Hospital were enrolled respectively. All patients were with suspicious recurrence after surgery showed by MRI and followed up for 6 months at least. The final diagnosis was determined with histopathological analysis or clinical follow-up. The maximum and mean standardized uptake value (SUVmax and SUVmean), tumor-to-background ratios (TBR) of SUVmax and SUVmean (TBRmax and TBRmean) were recorded and compared between patients with recurrence or without recurrence using independent-sample
5.A case-control study on the relationship of drinking water from farmland edge and digestive tract cancers
Zhen-Yu WU ; Rong-Fu CHEN ; Wang-Yan LIU ; Qiao-Yu YE ; Fan CHEN ; Zhen WANG ; Guan-Ping HUANG ; Xiao-Qing XIANG ; Guo-Bao ZHANG
Journal of Preventive Medicine 2014;(9):888-892
Objective To explore the relationship between drinking water from farmland edge and digestive tract cancers in rural areas.Methods A total of 180 cases of digestive tract cancers from Longquan city,Jinyun county and Qingtian county were selected and 360 controls with the same age group and sex were enrolled.1∶2 matched design of case-control study was used.The data was analyzed by Wilcoxon matched -pairs signed -ranks test.Results Overall,individuals who drank water from farmland edge were more likely to have digestive tract cancer among 3 areas (OR=4.005 ,95%CI:2.228-7.199).In Qingtian county the risk of digestive tract cancers in individuals who drank water from farmland edge was 5.375 times of control group population (95%CI:2.287 -12.635 ),But there was not statistically significant in Longquan city and Jinyun county (P >0.05 ).For gastric cancer,the proportion of drinking farmland edge water was significantly higher in cases than that in control group (OR=4.875,95%CI:2.007-11.839),while the difference was not statistically significant for liver cancer,colorectal cancer and esophageal cancer (P>0.05 ).In Qingtian county ,for gastric cancer,the proportion of drinking water from farmland edge was 5.750 times of control group population (95%CI:1.683-19.649).But there was not statistically significant in other cancers(P>0.05).Conclusion Drinking water near farmland edge may be one of the risk factors of gastric cancer in rural areas.
6.Nutritional support in children with pneumonia on mechanical ventilation by short-peptide enteral nutrition formula.
Xian-Jie HUANG ; Fei-Fei GUO ; Fan LI ; Jian-Chuang ZHAO ; Ya-Zhen FAN ; Na WANG ; Jun-Ying QIAO
Chinese Journal of Contemporary Pediatrics 2020;22(11):1209-1214
OBJECTIVE:
To observe the incidence of malnutrition and nutritional risk in children with pneumonia on mechanical ventilation in the pediatric intensive care unit (PICU), and to explore the nutritional support effect of short-peptide enteral nutrition formula.
METHODS:
A total of 68 children with severe pneumonia who were hospitalized in the PICU from October 2017 to October 2018 and required mechanical ventilation were enrolled for a prospective randomized controlled study. The children were randomly divided into a control group and an experimental group. Through the nasogastric feeding tube, the experimental group received the short-peptide enteral nutrition formula, and the control group received the intact-protein enteral nutrition formula. The weight-for-age Z score, STRONGkids nutritional risk score, and pediatric critical illness score of the two groups were evaluated. The serum levels of total protein, albumin, and prealbumin (PA) on admission and before discharge were measured. The gastrointestinal tolerance and clinical outcome indicators of the two groups were observed.
RESULTS:
Among the 68 mechanically ventilated children, 26 (38%) had malnutrition, including moderate malnutrition (10 cases, 15%) and severe malnutrition (16 cases, 24%); 10 cases (15%) had malnutrition at discharge. Sixty-three children (93%) had nutritional risk, including moderate nutritional risk in 21 cases and high nutritional risk in 42 cases. The moderate and high nutritional risk rates of the critical and extreme critical groups were significantly higher than those of the non-critical group (P<0.05). Compared with the control group, the experimental group had significantly shorter duration of mechanical ventilation and total length of hospital stay, significantly higher serum PA level and weight growth rate, and significantly better gastrointestinal tolerance (P<0.05). There were no significant differences in the incidence of ventilator-associated pneumonia and disease outcome between the two groups (P>0.05).
CONCLUSIONS
The detection rates of malnutrition and nutritional risk in children with pneumonia on mechanical ventilation are relatively high. Short-peptide enteral nutrition formula can help improve their treatment outcome and are more suitable for nutritional support in critically ill children on mechanical ventilation.
Child
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Critical Illness
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Enteral Nutrition
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Humans
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Peptides
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Prospective Studies
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Respiration, Artificial
7.Renal function of donors and recipients after living donor kidney transplantation in a Chinese cohort.
Nian-qiao GONG ; Chang-sheng MING ; Fan-jun ZENG ; Wei-jie ZHANG ; Zhen-bin LIN ; Ping ZHOU ; Xiao-ping CHEN ; Zhi-shui CHEN
Chinese Medical Journal 2011;124(9):1290-1295
BACKGROUNDLiving donor kidney transplantation (LKT) has been booming in China. This study aimed to elucidate the renal function of both Chinese donors and recipients after the donation and transplantation.
METHODSOne hundred and forty-one pairs of donors and recipients for LKT were randomly selected and followed up for up to seven years. The donors' and recipients' renal function was recorded before and after operation.
RESULTSThe donors presented a mean age of (43.9 ± 7.5) years at donation. The female contributed 101/141 (71.6%) in all donors, and no effect was shown between genders on healthy donors' renal function. The donors' glomerular filtration rates (GFR) were (119.5 ± 20.4) ml/min, (85.2 ± 17.6) ml/min, (87.2 ± 15.9) ml/min, (82.1 ± 14.6) ml/min and (83.0 ± 13.7) ml/min preoperatively, and for five days, three months, one year and beyond one year after the operation. The donors for the period of 1 - 3 years, 3 - 5 years and more than 5 years after donation showed GFR as (83.9 ± 12.7) ml/min, (83.0 ± 17.6) ml/min, and (80.9 ± 20.8) ml/min, respectively, no statistically significant difference was found. Moreover, no significant clinical changes in blood pressure and proteinuria were found among the donors. In the recipients, delayed graft function (DGF) rate was 6.4%, acute rejection rate was 11.3%, and GFR were (66.5 ± 16.4) ml/min, (73.2 ± 19.6) ml/min and (63.9 ± 18.6) ml/min respectively at three months, one year and beyond one year post-transplantation respectively.
CONCLUSIONThe donors/recipients of LKT in Chinese population experience well-functioning remaining/donor kidneys.
Adult ; Aged ; Blood Pressure ; physiology ; China ; Cohort Studies ; Female ; Glomerular Filtration Rate ; physiology ; Humans ; Kidney Function Tests ; Kidney Transplantation ; Living Donors ; Male ; Middle Aged ; Postoperative Period ; Proteinuria ; physiopathology
8.Determination of decapeptide LXT-101 in plasma by HPLC-MS/MS and its pharmacokinetics in Beagle dogs.
Ai-ying KONG ; Zhen-qing ZHANG ; Jian-zhong QIAO ; Fan ZHANG ; Wen-xia ZHOU ; Ke-liang LIU ; Jin-xiu RUAN
Acta Pharmaceutica Sinica 2008;43(9):946-950
This paper developed a sensitive and specific liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/MS) method for the determination of decapeptide LXT-101 in Beagle dog plasma. Plasma samples spiked with internal standard (IS) were treated with acetonitrile to precipitate the protein. Selected reaction monitoring (SRM) using the precursor --> product ion combinations of m/z 472.1-->587.9 and m/z 502.8-->633.8 were used to quantify LXT-101 and IS, respectively. The linear calibration curves were obtained in the concentration range of 0.5 - 500.0 ng x mL(-1). The limit of quantification (LOQ) was 0.5 ng x mL(-1). The inter-day and intra-day precision (RSD) across three validation run over the entire concentration range was below 10.9%, and the accuracy (RE) was within +/- 1.8%. The main pharmacokinetic parameters of LXT-101 after muscle injection of 20 microg x kg(-1) were as follows, AUC(0-t): (176.8 +/- 116.7) microg x h x L(-1), MRT(0-t): (2.52 +/- 0.53) h, T(1/2): (1.4 +/- 0.3) h; CL: (0.16 +/- 0.09) L x h(-1) x kg(-1), and Vd: (0.30 +/- 0.16) L x kg(-1), respectively. The method is proved to be specific, sensitive and suitable for the investigation of LXT-101 pharmacokinetics in Beagle dog.
Animals
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Antineoplastic Agents
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administration & dosage
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blood
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pharmacokinetics
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Area Under Curve
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Chromatography, High Pressure Liquid
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Dogs
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Gonadotropin-Releasing Hormone
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antagonists & inhibitors
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Injections, Intramuscular
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Male
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Oligopeptides
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administration & dosage
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blood
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pharmacokinetics
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Spectrometry, Mass, Electrospray Ionization
9.Drug distribution in gastric cancer and adjacent tissues by preoperative intraperitoneal chemotherapy with Co-fluorouracil liposome.
Yong LI ; Bin-wei LIU ; Wen-li DU ; Zhen-chuan SONG ; Qun ZHAO ; Li-qiao FAN ; Jin-qiang YANG ; Qi-jun LI ; Ming-xia WANG ; Zhi-kai JIAO ; Zhi-dong ZHANG
Chinese Journal of Oncology 2004;26(10):638-640
OBJECTIVETo examine the distribution of fluorouracil in gastric cancer (CA), lymph node (LN), normal gastric mucosa (NG), peritoneum (PE), greater omentum (GO) and lesser omentum (LO) by preoperative intraperitoneal chemotherapy with Co-fluorouracil liposome (Co 5-Fu), and offer an experimental basis for clinic practice.
METHODSNinety-six gastric cancer patients were divided into four groups: Co 5-Fu i.v. injection group (Co 5-Fu i.v.), Co 5-Fu intraperitoneal perfusion group (Co 5-Fu i.p.), 5-Fu i.v. injection group (5-Fu i.v.) and intraperitoneal perfusion group (5-Fu i.p.) given on day-2, day-1 and 60 minutes before operation. Fluorouracil concentration in all tissues collected during operation were examined by high performance liquid chromatography (HPLC).
RESULTSThe fluorouracil concentration in the tissues in Co 5-Fu i.p. group was significantly higher than that in Co 5-Fu i.v. or 5-Fu i.p. group (P < 0.05 or P < 0.01), and that in 5-Fu i.p. group was greatly higher than that at 5-Fu i.v. group (P < 0.01). In Co 5-Fu i.p. group, the concentration of drug in LN, CA, PE, NG, GO and LO decreased gradually with the former 3 tissues significantly higher than the latter 3 tissues (P < 0.01), and adjacent lymph node was the highest. In Co 5-Fu i.v. group, the ranking was LN, CA, NG, PE, GO and LO with the former 3 tissues significantly higher than the latter 3 tissues (P < 0.01) and showing tumor tissues higher than the other tissues (P < 0.01). In 5-Fu i.p. group, the ranking was PE, LN, CA, NG, GO and LO with the former 2 tissues significantly higher than the latter tissues (P < 0.01).
CONCLUSIONCo 5-Fu possesses drug targeting, slow release and long effect in gastric cancer tissues and adjacent lymph nodes. Preoperative chemotherapy with Co 5-Fu i.p. is more advantageous than 5-Fu given i.v. or 5-Fu i.p.
Aged ; Antimetabolites, Antineoplastic ; administration & dosage ; pharmacokinetics ; Female ; Fluorouracil ; administration & dosage ; pharmacokinetics ; Gastric Mucosa ; metabolism ; Humans ; Infusions, Parenteral ; Injections, Intravenous ; Liposomes ; Lymph Nodes ; metabolism ; Male ; Middle Aged ; Omentum ; metabolism ; Panax ; chemistry ; Peritoneum ; metabolism ; Polysaccharides ; administration & dosage ; isolation & purification ; pharmacokinetics ; Preoperative Care ; Stomach Neoplasms ; drug therapy ; metabolism ; pathology
10.Surgical treatment of acute embolism of the upper extremity.
Long-hua FAN ; Jian-rong YE ; Wei-guo FU ; Da-qiao GUO ; Bin CHEN ; Jue YANG ; Jun-hao JIANG ; Zhen-yu SHI
Chinese Journal of Surgery 2003;41(1):50-51
OBJECTIVETo study the methods of surgical treatment and the prognosis of acute embolism of the upper extremity.
METHODSBalloon catheter embolectomy through the brachial artery was performed in 18 patients with acute embolism of the upper extremity.
RESULTSBoth the pulse of the radial and ulnar artery could be palpated in 8 patients, either the pulse of the radial or ulner artery could be palpated in 9 patients. The temperature of the upper extremity was increased in the patient whose embolectomy was performed in the 6th day after onset of the illness. Three patients died postoperatively.
CONCLUSIONSEmbolectomy through the brachial artery is an effective method to treat acute embolism of the upper extremity. Elderly and heart and pulmonary diseases are the high risk factors for postoperative death.
Acute Disease ; Adolescent ; Adult ; Aged ; Cause of Death ; Child ; Embolism ; etiology ; surgery ; Female ; Humans ; Male ; Middle Aged ; Upper Extremity ; blood supply