1.Study on Complex System Model for Relationship between Chinese Herbal Nature Combination and Viscera
Lan WANG ; Yun WANG ; Yanjiang QIAO
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(3):531-534
Chinese herbal nature combination (CHNC) is the particular combination of nature, taste and channel tropism, which can be used to express the effect of Chinese herbal medicine in the clinical application concisely. The complex system model for the relationship between CHNC and viscera was constructed in this paper based on the thinking model of viscera theory. The model is able to reveal the functional features of CHNC. The model will promote research on the relationship between CHNC and viscera and provide new ideas for clinical applications of CHNC.
2.Research on Features of Incompatible Medicaments in Prescriptions based on Chinese Herbal Nature Combinations
Xiaohe LI ; Yun WANG ; Yanjiang QIAO
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(3):613-616
The eighteen incompatible medicaments is the incompatibilities in traditional Chinese medicine (TCM). However, in some special occasion, the incompatible medicaments can also be used in one prescription in the clinical applications. In order to reveal the theoretical basis for applications of incompatible medicaments in prescriptions, we analyzed ancient prescriptions and found that there are contrary Chinese herbal nature combina-tions (CHNCs) which have the same meridian tropism as well as the opposite nature and taste in prescriptions. In clinical applications, one of the non-contrary CHNCs was selected as the main response to syndrome differentia-tion. The contrary CHNCs in the same meridian tropism were used to restrict each other and therefore have the protective effects. The features found in this paper will be beneficial to further research on the rational applica-tion of incompatible medicaments.
3.Research on Effective Component Group Identification from Traditional Chinese Medicine Formula based on Entity Grammar Systems
Ji LUO ; Yun WANG ; Yanjiang QIAO
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(3):482-488
This study was aimed to explain the relationship between chemical component and therapy objective and to identify effective component group (ECG). The objective of this study is to build a new method to identify the ECG. Traditional Chinese medicine (TCM) formula and one of its treated diseases were selected as the re-search object. The entity grammar systems (EGS) were used as the theoretical framework. A grammatical method for ECG identification was constructed. The component-disease relationship was inferred and the ECG was identi-fied with these inference results. In this paper, 16 compounds which act to 12 proteins in Type 1 diabetes melli-tus (T1D) disease network were identified from Bai-Hu Tang plus Xiao-Ke Fang and 9 chemical compounds were determined as the candidate effective components group. The results indicated that this method can be used to identify ECG and provide a new way to elucidate the molecular mechanism of TCM formula.
4.Screening of the Microbe Producing Docosahexaenoic Acid from Seawater and Identification on a Strain of High Yield
Yu-Qiao ZHAO ; Yun-Jian DU ; Li-Yan WANG ;
Microbiology 1992;0(04):-
Microbes that produce Docosahexaenoic Acid were isolated from seawater. 160 strains capable of producing lipids were screened out using Sudan Black B dying method from 280 seawater samples. From 60 strains of microorganisms producing bigger lipid particles, 7 strains of them capable of producing lipids more than 8% were obtained with Soxhlet abstracting method in the first screening. In the secondary screening from 10 strains with high lipids yield, strain 7-3 capable of producing 15.9% lipids was obtained, in which the content of DHA(Docosahexaenoic Acid)is 45.2%. Strain 7-3 was identified as Brettanomyces based on its morphological properties, cultural characteristics, physiological and biochemical properties.
5.The Application of the Different Methods in Different Contents in Pharmacological Theory Teaching
Qiao-Yun WANG ; Guan-Ying WEI ; Feng-Jie WU ;
Chinese Journal of Medical Education Research 2006;0(10):-
Different teaching methods were chosen based on different teaching contents in pharmacological theory teaching.Then teaching contents seem simple,interesting and acceptable.The students were more interested in the subject.The results of investiga- tion showed that teaching quality had improved through using this technology.
6.Standardization of the terms for Chinese herbal functions based on functional targeting.
Bin XIAO ; Ou TAO ; Hao GU ; Yun WANG ; Yanjiang QIAO
Journal of Integrative Medicine 2011;9(3):252-6
Functional analysis concisely summarizes and concentrates on the therapeutic characteristics and features of Chinese herbal medicine. Standardization of the terms for Chinese herbal functions not only plays a key role in modern research and development of Chinese herbal medicine, but also has far-reaching clinical applications. In this paper, a new method for standardizing the terms for Chinese herbal function was proposed. Firstly, functional targets were collected. Secondly, the pathological conditions and the mode of action of every functional target were determined by analyzing the references. Thirdly, the relationships between the pathological condition and the mode of action were determined based on Chinese medicine theory and data. This three-step approach allows for standardization of the terms for Chinese herbal functions. Promoting the standardization of Chinese medicine terms will benefit the overall clinical application of Chinese herbal medicine.
7.Detection of Th17 cell in patients with bronchial asthma and itssignificance
Rong SHI ; Shan QIAO ; Yun WANG ; Yuezhen WEN
Chinese Journal of Primary Medicine and Pharmacy 2015;(13):2010-2012,2013
Objective To detect the expression of Th17 levels about peripheral blood in patients with bron-chial asthma in bronchoalveolar lavage fluid,and to investigate its effect in pathogenesis of bronchial asthmaand. Methods Patients with acute bronchial asthma from 2014 April to 2014 November were collected in the experiment. There are 52 cases as observation group (group of patients with asthma),and the patients were then divided according the severity (mild,moderate,severe);in addition,select 50 healthy people in the same period in our hospital as con-trol group healthy control group.Collect peripheral blood and bronchoalveolar lavage fluid,the expression of specific transcription factors ROR gamma T and cytokine IL -17 in the peripheral blood and bronchoalveolar lavage fluid in Th17 cells levels were detected by real -time fluorescent quantitative PCR.Results The expression of IL -17,ROR gamma T in peripheral blood and bronchoalveolar lavage fluid of the observation group were higher than the control group;the expression of IL -17,ROR gamma T in alveolar lavage fluid quantity and peripheral blood with severe patients in the observation group were higher than that in the mild patients,differences were statistically significant (P <0.05).Conclusion There are 17 auxiliary T lymphocytes in patients with bronchial asthma in vivo (Th17) advantage of expression,Th17 may play an important role in the pathogenesis of bronchial asthma.Bronchial asthma patients body may have advantage to heip expression of T lymphocytes 17 (Th17).Th17 may play an important role in the pathogenesis of bronchial asthma.
8.Improvements in Similarity Algorithms Based on Similarity System Theory
Xueyan ZHAN ; Xinyuan SHI ; Xiaori ZHAN ; Yun WANG ; Yanjiang QIAO
Chinese Journal of Analytical Chemistry 2010;38(2):253-257
For solving the problem that common similarity algorithms are insensitive to the relative differences of different chromatographic fingerprints data, this paper improved the algorithms of improved extent similarity), which named new improved extent similarity. It was confirmed that new improved extent similarity could distinguish) the samples with the same total difference and different distribution of relative differences. by applying) the similarity algorithm to simulated data and the chromatographic fingerprints of nine batches Rukuaixiao tablets. New improved extent similarity could reflect the relative differences of peak areas more sensitively when the relative differences of common peak areas was less than 100%. The result indicates that new improved extent similarity can reflect the large deviation from the established proportion of components, which can be applied to the control of the fluctuation of the established proportion of effective components and the process quality control of Traditional Chinese Medicine .
9.Practice on Early Exposure to the Training of Scientific Research for the Students on the Seven-year Program of the Clinical Medicine
Yun ZHANG ; Min QIAO ; Shipeng WANG ; Weijun SONG
Chinese Journal of Medical Education Research 2003;0(02):-
In China medical university 8 weeks early exposing to scientific research have been arranged for the students on seven-year program of clinical medicine. The purpose is to let the students understand scientific research procedures based on the tutor's research project. The students gain great achievements. The result of questionnaire shows that the attitudes of the students are positive and 81% of them are satisfied in general. The paper also summarizes the experiences of the practice.
10.Research on Identification Model of Chinese Herbal Medicine by Texture Feature Parameter of Transverse Section Image
Ou TAO ; Zhaozhou LIN ; Xianbao ZHANG ; Yun WANG ; Yanjiang QIAO
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(12):2558-2562
This study was aimed to establish the classification method of Chinese herbal medicine based on feature parameters extracted from images of herbal transverse section, in order to explore the feasibility of automatic identi-fication method of herbal medicine. The extracted 26 parameters of 18 herbal medicine images by gray-level co-oc-currence matrix and grayscale gradient matrix were used as the basic data set. And the minimum covariance determi-nant (MCD) was used to delete the outliers. A total of 18 identification models were established using the native Bayes method and BP neural network methods. The results showed that the average correct rates of models were 90%. It was concluded the feasibility of using these models in the establishment of the automatic identification method of herbal medicines. It provided new technologies for the quantitative, scientific and objective identification of Chinese herbal medicine.