1.Development and Study of Associative Memory Neural Network
Chinese Medical Equipment Journal 1993;0(05):-
The concept and important role of associative memory neural network are introduced.The development of associative memory neural network is also summarized along with other neural networks such as the Hopfield neural network,the neural network composed of FitzHugh-Nagumo neuron model,the neural network composed of Hodgkin-Huxley neuron model.
2.Meta analysis of the level of plasma D-dimer in patients with ovarian cancer
Xuefeng QIAO ; Donghong ZHANG ; Wei CUI
Chinese Journal of Laboratory Medicine 2014;(9):696-700
Objective To evaluate the correlation between plasma D dimer levels and ovarian cancer, as well as its pathologic staging.Methods According to the inclusion and exclusion criteria , articles published about the correlation between plasma D dimer levels and human ovarian cancer were searched by means of PubMed , Embase, CNKI and WanFang Data from their inception to December 31th , 2013.In addition , references′list of the included articles and their related citations in Pubmed were also reviewed for additional articles.After quality assessment of all studies , Meta-analysis and ANOVA were performed with RevMan 5.2 and SAS 9.1 for statistic analysis.Results A total of 13 articles were identified, including 679 cases of ovarian cancers , 685 cases of benign controls and 477 cases of healthy controls.Meta-analysis revealed that:(1) Plasma D dimer levels in ovarian cancer groups were higher than that in benign control groups ( Z =8.61, P <0.000 01 ) and healthy control groups ( Z =6.76, P <0.000 01);(2) Plasma D dimer levels in benign control groups were higher than that in healthy controls (Z=3.15, P=0.002); (3) Plasma D dimer levels in advanced ovarian cancer FIGO (Ⅲ-Ⅳ) were higher than that in early cancer FIGO (Ⅰ-Ⅱ) (Z=3.38, P=0.000 9);(4)But there were no difference between relapse groups and remission groups (Z=1.19, P=0.23).ANOVA revealed that:(1) There were significant difference of D dimer levels among ovarian cancer groups or benign groups , healthy control groups; ( 2 ) Significant increasing of D dimer levels was revealed by Pairwise ANOVA from healthy controls, benign controls to ovarian cancer.Conclusions Plasma D dimer levels were high in patients with ovarian cancer , especially in FIGO (Ⅲ-Ⅳ) ovarian cancer.No difference of D dimer levels were investigated between relapse phase and remission phase.
3.Cardiac involvements in adult polymyositis or dermatomyositis: a qualitative systematic review
Lu ZHANG ; Wei QIAO ; Guochun WANG
Chinese Journal of Rheumatology 2012;16(3):167-172
ObjectiveTo investigate the clinical features of cardiac involvement in polymyositis or dermatomyositis(PM/DM).MethodsAll articles published in Chinese and English were retrieved by searching the electronic resource databases.Theeligible articles that metthe predefined inclusion and exclusion criteria were included and then a systemic review was performed.ResultsTotally 23 articles were enrolled in this study,including 1452 patients.The incidence of cardiac involvement was 27.1%-85%.Heart failure was the most frequent (43.8%-76.9%) symptom.Among the abnormal ECG and UCG,the incidence of conduction abnormalities,left ventricular diastolic dysfunction andhyperkinetic left ventricular contraction 25%-38.5%,27.3%-51.5% and 11.5%-42.3% respectively.The pathological findings revealed myocardial inflamma-tion,degenerative changes and necrosis similar to those findings in skeletal muscles.Some patients'condition were improved aftergluco-corticoid stero and immunosuppressant treatment.Thirtypatients (30.9%) died as a direct result of heart disease.ConclusionHeart abnormalities are common in patients with PM/DM,most of them are subclinical,however.The efficacy of gluco corticoid steroid and immunosup-pressant treatment are uncertain.Cardiac involvement is a common cause of death.
5.Correlation between two animal models of state anxiety in Kunming mice: evidence from open field test and light-dark box
Shiguang SUN ; Sheng WEI ; Peng SUN ; Mingqi QIAO ; Huiyun ZHANG
Chinese Journal of Behavioral Medicine and Brain Science 2012;21(2):101-104
ObjectiveTo explore the correlation between open field test(OFT) and light-dark box (LDB),as two animal models of state anxiety in Kunming mice.MethodsThe behavior of adult,male,Kunming mice in OFT and LDB was recorded by sequence,for five minutes,with a one-week inter-trial interval.The following parameters were evaluated:percentage of time exploring in the OFT central area( OFT-Ctime% ) ; percentage of squares crossing in the OFT central area( OFT-Ccross% ) ; total number of squares crossing in OFT(OFT-Cross) ;total number of rears in the OFT(OFT-Rear) ; number of fecal boli in OFT(OFT-FB) ; percentage of time exploring in the LDB light area( LDB-Ltime% ) ; percentage of squares crossing in the LDB light area( LDB-Lcross% ) ;and percentage of rears in the LDB light area( LDB-Lrear% ) ; transitions between two areas in LDB( LDB-Transition) ; total number of squares crossing in LDB(LDB-Croas) ; total number of rears in LDB(LDB-Rear) ; number of fecal boli in LDB (LDB-FB).Subsequently,factor analysis,cluster analysis and correlation analysis were calculated for these parameters.ResultsFactor analysis and cluster analysis of variances from either OFT or LDB revealed a three behavioral dimensions:anxiety factor ( loaded by OFT-Ctime%,OFT-Ccross% or LDB-Ltime%,LDB-Lcross%,LDB-Lrear% ),activity factor ( loaded by OFT-Cross,OFT-Rear or LDB-Transition,LDB-Cross,LDB-Rear) and emotionality factor(loaded by OFT-FB or LDB-FB).While all the variances from both OFT and LDB in combination were analyzed,it could be seen as five components:' LDB-anxiety factor ( loaded by LDBLtime%,LDB-Lcross% and LDB-Lrear% ),' OFT-anxiety factor ( loaded by OFT-Ctime% and OFT-Ccross% ),'LDB-activity factor (loaded by LDB-Transition,LDB-Cross and LDB-Rear),'OFT-LDB-emotionality factor( loaded by OFT-FB and LDB-FB) and 'OFT-activity factor (loaded by OFT-Cross and OFT-Rear).Good correlation were found between OFT/LDB factors alone and in combination,such as OFT-emotionality factor and LDB-emotionality factor(Pearson =0.383,P<0.05),LDB-anxiety factor and 'LDB-anxiety factor( Pearson =0.989,P<0.01 ),OFT-anxiety factor and 'OFT-anxiety factor( Pearson =0.934,P < 0.01 ),LDB-activity factor and 'LDB-activity factor ( Pearson =0.956,P < 0.01 ),OFT/LDB-emotionality factor and ' OFT-LDB-emotionality factor ( Pearson =0.835,P<0.01 ;Pearson =0.696,P<0.01 ),OFT-activity factor and 'OFF-activity factor( Pearson =0.926,P<0.01 ).ConclusionEither OFT or LDB comprised three behavioral dimensions:anxiety factor,activity factor and emotionality factor; however,it was difficult to establish face validity as a point-to-point concordance between OFT and LDB.Attention should be paid to heterogeneity of animal models when OFT and LDB were in combination as a behavionomics to evaluate anxiolytics in Kunming mice.
6."Conceptual Change:""Exploring Object, Changing Recognition"", Guiding Theory, Teaching and Thinking Reform---Series of Studies on the Modern Basic Theory of Traditional Chinese Medicine (Part 2-Ⅲ)"
Mingqi QIAO ; Sheng WEI ; Huiyun ZHANG ; Xiuzhen HAN
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(8):1678-1687
The concept is cell of the theory. Starting from the concept, is the first and important step in building the modern basic theory of traditional Chinese medicine. Based on the early thought of Changes from phenomenon description to entity elucidation, we firstly introduce conceptual change in this paper and point out its basic meaning and role. To accurately apply the new concept, we have analyzed and demonstrated the concept and its expression object, the concept words' expression forms, as well as the concept explanatory power in details, and pointed out the problems because of ignoring these recognition in researching the concept of chinese medicine and its solutions. We have summarized the laws of the international scientific community realizing the conceptual change focus on the object, explore the unknown, propose new knowledge. and proposed the definition of conceptual change of the basic theory of traditional Chinese medicine. According to preliminary findings we have generalized the goal and standard to achieve the conceptual change of the basic theory of traditional Chinese medicine and gave examples of proof. As such we have draw an conclusion: the concepts of the basic theory of traditional Chinese medicine form the scientific concepts of the modern basic theory of traditional Chinese medicine through conceptual change, and thus guiding the theory, teaching and thinking reform of the Chinese medicine.
7.Effect of Baixiangdan Capsule on expression and behavior and sex hormone of rhesus monkey with premenstrual syndrome and liver-qi invasion
Haiping WANG ; Sheng WEI ; Jiancheng ZONG ; Mingqi QIAO ; Huiyun ZHANG
Chinese Traditional Patent Medicine 1992;0(05):-
AIM: To study the effect of Baixiangdan Capsule (Radix paeoniae alba and Rhizoma cyperi) on expression and behavior and sex hormone of rhesus monkey with premenstrual syndrome (PMS) and liver-qi invasion. METHODS: Twenty-four young rhesus monkeys in high rank and in the ovalatory menstrual cycle were isolated and squeezed 7 h a day for 5 d by specifically designed isolating-cage. At the same time Baixiangdan Capsule orally administed was compared with the control group of Jingqianping Granule. The expression and behavior changes of rhesus monkeys were observed and evaluated by The Measure Table of Emotion Evaluation of Female Experiment Macaque. And the levels of prolactin (PRL),estradiol (E2) and progesterone (P) in serum were investigated by radioimmunoassay. RESULTS: The scores of anxiety factors of the model monkeys were higher than the normal and the serum E2,and P levels decreased and PRL level increased significantly in the control group. As compared with the model group,Baixiangdan Capsule reduced the enhancing anxiety factor scores and also could increase the lower E2 and P levels in serum obviously and decrease PRL level. CONCLUSION: The above findings suggest that Baixiangdan Capsule has good regulative effects and makes it to the normal state on the abnormal expression and behavior and serum sex hormones of rhesus monkey with PMS and liver-qi invasion.
8.Establishment of Modern Basic Theory of Traditional Chinese Medicine, Part Ⅰ New Concept:Theoretical Premise, Reveal Connotation of Concept Towards Modern Science
Mingqi QIAO ; Sheng WEI ; Haijun WANG ; Peng SUN ; Huiyun ZHANG
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(2):216-224
Editor's Notes: The basic theory of traditional Chinese medicine is the theoretical foundation of Chinese medicine , modernization of Chinese medicine needs of the modern theory of Chinese medicine urgently . However , it is always the important issues about how modern Chinese medicine theory should be created , and what kind of theory should have been established concerned and explored by domestic and foreign counterparts in tradi-tional Chinese medicine . To lead the development of modern Chinese medicine theory , Modern Basic Theory of Traditional Chinese Medicine series of symposiums are set up specially in the current Review column, and discussed thoroughly and systematically using three consecutive pats respectively. Among them, part I contains 3 articles about new concepts, new theories, new disciplines; part II contains 5 articles about new ideas, new norms, how to clear concept, how to verify hypotheses, why to evaluate theory; part III contains 12 articles about concept of wholism updating, treatment based on syndrome differentiation development, viscera-state doc-trine innovation, pathogeny, etiology, pathogenesis, prevention, principle of treatment, knowledge structure, cogni-tion structure , monographic study , 5-year outlook . Published article on this issue is the first one belong to new concept of part I. In this paper, we want to describe the denotation and connotation of the new concept of the modern basic theory of traditional Chinese medicine from three aspects of a concept: a label , a theoretical definition , and an operational definition learning from the international academic understanding of scientific concepts, demonstrate the necessity of theoretical premise to the research and establishment of the modern basic theory of traditional Chinese medicine and the need to build on , illustrate the inevitable trend toward modern science . The whole article contains profound meaning and a certain breakthrough and innovation. We are expected to cause concerns and discusses of experts and scholars through this article .
9.Chemical Constituents in Groups of Effective Components Extracted fromXiaoxuming Decoction
Qiao ZHANG ; Juan SHEN ; Yiwu ZHAO ; Zhenzhong WANG ; Wei XIAO
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;17(3):583-586
This article was aimed to study the chemical constituents in groups of effective components extracted from Xiaoxuming Decoction. Twelve compounds were isolated and purified by dynamic axial compression column chromatography. Their chemical structures were identified by spectral analysis. The results showed that twelve compounds were isolated and identified as octacosanoic acid(1), cetanol(2), oroxylin A(3), wogonin(4), baicalein(5), tetrandrine(6), fangchinoline(7), wogonoside(8), baicalin(9), paeoniflorin(10), amygdalin(11), manntol(12). It was concluded that all compounds were isolated from this compound prescription for the first time.
10.Hypoglycemic Effect of Cortex Lycii Radicis (CLR) on Alloxan induced Diabetic Mice
Jing ZHOU ; Lin MENG ; Jianan HUANG ; Yanwen ZHANG ; Wei QIAO ;
Chinese Traditional Patent Medicine 1992;0(06):-
Objective:To observe the hypoglycemic effects of Cortex Lycii Radicis (CLR) on alloxan induced diabetic mice.Methods:The alloxan induced diabetic mice were given drug decoction of CLR[2.5g/(kg?d) -1 , or 5.0g/(kg?d) -1 )] for successive 2 weeks, The blood sugar level was determined with GOD method.Results:There were remarkedly differences in the levels of blood sugar between before and after treatment of various groups. ( P