1.Toxicological mechanisms of lung injurant and poisoning management
Chinese Journal of Pharmacology and Toxicology 2016;30(12):1424-1430
The lung is one of the important target organs of chemical poisoning. Chemical toxins may be absorbed into body through blood circulation of the lungs,inducing systemic damage. Mean?while,they may also directly damage the lungs themselves. Lung injury is usually rapid and life-threatening. This review systematically introduced the toxicological mechanisms and poisoning management of lung injury agents.
3.Costimulatory molecules and allograft rejection
Cancer Research and Clinic 2006;0(12):-
Allograft rejection after xero organ transplantation rejection, especially acute rejection is still the major reason of failure and death. Active T cell play key roles in allograft rejection. It has been showed that the expressions of costimulatory molecules are associated with xero organ transplantation rejection. The pathways of CD28/CTLA-4 and CD40/CD40L are important costimulatory pathways that cause T cell activation.The article emphasizes on the role of CD28/CTLA-4-B7 pathway in allograft rejection.
4.Considerations of curriculum arrangement for professional English education for pharmacog-nosy-major graduate students
Chinese Journal of Medical Education Research 2015;(9):901-904
Pharmacognosy (Chinese Medicine) discipline has a long history and International cooperation is more and more frequent, but the communication of the Chinese traditional medicine cul-ture is very difficult. In order to solve this problem, it is urgent to improve the professional English level of the students. Thus, combined with the education survey and interview results, as well as the reports in previous studies and our own experience, we think about how to set pharmaceutical profes-sional English course and put forward some suggestions such as the innovation of curriculum organiza-tion strategy, convergence of basic English course, teaching content and form being closely linked to academic activities, and paying attention to highlighting the subject characteristics of pharmacognosy (Pharmacy).
6.Hard metal lung disease.
Chinese Journal of Industrial Hygiene and Occupational Diseases 2015;33(7):558-560
Alloys
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toxicity
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Cobalt
;
toxicity
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Humans
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Lung Diseases
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chemically induced
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Tungsten
;
toxicity
7.Three cases of sharply reduced blood platelets after transcatheter closure of patent ductus arteriosus.
Ye TIAN ; Xiao-qiao LIU ; Ping ZHANG
Chinese Journal of Cardiology 2012;40(4):340-341
Catheterization
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adverse effects
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Child
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Ductus Arteriosus, Patent
;
therapy
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Female
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Humans
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Male
;
Platelet Count
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Thrombocytopenia
;
etiology
;
Young Adult
8.Recent Methods and Strategies for in vivo Metabolic Study of Traditional Chinese Medicines
Xue QIAO ; De'an GUO ; Min YE ;
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(3):532-537
Traditional Chinese medicine (TCM) contains a big array of chemical constituents. These constituents un-dergo various metabolic reactions to produce complex in v iv o metabolites. Identification and distribution of these metabolites are important to reveal the effective constituents from a complex formulation. Recently, developments had been made to elucidate the complex metabolic process. In this review, we summarized the methods and strategies developed for TCM metabolism. Application of these metabolic results has also been discussed.
9.Relationship of mean color vessels density and microvessel density in rectal cancer and their clinical significance
Zhibin QIAO ; Weihua YE ; Yuzhen ZHAO
Chinese Journal of Ultrasonography 2010;19(6):503-505
Objective To explore the relationship of the mean color vessels density (MCVD) and pathologic microvessel density(MVD) in rectal cancers and their relation with T stags and lymph node metastasis.Methods MCVD were caculated preoperationly with transrectal color power angiography(TRCPA).After operation MVD was assessed immunohistochemically using anti-CD105 monoclonal antibody.The relationships within MCVD, MVD and T stages and lymph node metastasis were analysed.Results There were positive correlation between MCVD and MVD (r=0.763, P<0.01) in rectal cancer.There were significant difference of MCVD and MVD in both the depth of carcinoma invasion and metastasis of lymphatic nodes( P<0.05).Conclusions MCVD can display features of the blood supply and distribution of pathologic microvessels and reflect the development of rectal cancers.MCVD is a credible index to choose available treatment and to evaluate prognosis before operation of rectal cancer.
10.Effect of human telomerase antisense oligodeoxyribonucleotides on the growth in hibition of gastric cancer cell lines with well, moderate and poor differentiati on
Jing YE ; Yunlin WU ; Minmin QIAO
Chinese Journal of Digestion 2001;0(11):-
Objective To investigate the effect of specialized human tel omerase antisense oligodeoxyribonucleotides (AS-ODN) on the growth inhibition o f well, moderate and poor differentiated gastric cancer cell lines, and to explore its inhibitory mechanism and the correlation between the inhibition ratio of gastric cancer cells and differentiation of the tumor cells. Methods Under the given circumstances, three distinct differentiated gastric cancer cell lines were treated with AS-ODN. The telomerase a ctivities were measured by modified telomeric repeat amplification protocal assa y. The cell viability was detected by Trypan blue test, and the cell apoptosis was determined by cell morphological observation under light and electromicroscope, flow cytometry an d TUNEL assay. Results The telomerase activity and cell growth were apparently suppressed in MK N45 and SGC7901 cells, under defined concentrations of AS-ODN. Whilst, in MKN28 cells, only telomerase activity was suppressed at same concentration . There were no obvious changes in non-antisense oligomers treated group. The apoptotic features of MKN45 and SGC7901 were noticed by microscopic observa tion, TUNEL assay, after three distinct gastric cancer cell lines being continuo usly exposed to 10 ?mol/L AS-ODN for 96 h. Furthermore, the flow cytometric analy sis verified that the average apoptotic rate of MKN45 and SGC7901 was 44.75% and 33.56% respectively, but there were no obvious changes in non-antisense oli gomers treated group (P