Objective To investigate the relation of resistant index and function of transposited ovaries following radical hysterectomy in young women with early stage of cervical cancer.Methods A total of 22 young women(aged from 26 to 40 years old)with early stage of cervical cancer(FIGO Ⅰ a or Ⅱ a)were studied from Aug.1997 to Sep.2004 in the Affiliated Hospital of Inner Mongolia Medical Collage.Ovarian transposition was performed at the time of radical hysterectomy and pelvic lymphadenectomy in 12 cases who received postoperative radiotherapy;the rest 10 cases did not receive postoperative radiotherapy.Ovarian function was evaluated by serum FSH,LH,E_2 and B-ultrasonography in all of the cases.Results There was a statistically significant difference between the radiotherapy group and the non-radiotherapy group in serum E_2,FSH,LH levels and RI at the 24th month postoperatively.RI had a negative correlation with E_2 and positive correlation with FSH.Conclusion Ovarian transplantation can preserve the endocrine function of ovary for young women with cervical cancer.RI has a negative correlation with E_2 and positive correlation with FSH.RI is the important index of supervising ovarian function.Postoperative radiotherapy can influence RI and ovarian function.

Objective To determine the levels of radiation-induced expressions of HIF-1α and Survivin in three human lymphoma cell lines with or without HIF-1a specific antagonist or HIF-1a siRNA transfection and to explore the possible mechanism of cell radioresistance.Methods Namalwa,Ramos,Raji cells were irradiated with X-rays with or without the combination of echinomycin (EC),a HIF-1α specific inhibitor,or transfection of HIF-1α siRNA.Then the expression levels of HIF-1α and Survivin proteins and mRNAs were determined by Western blot and real-time PCR,respectively.Results After irradiation,the expression level of HIF-1α protein was up-regulated at 10-20 h followed by up-regulation of survivin protein at 24 h (t =7.53-31.31,P ＜ 0.01 ) in three lymphoma cell lines.Radiation-induced up-expression of survivin protein was significantly reduced by either HIF-1α inhibition or EC treatment (t =7.21-32.81,P ＜0.01 ).However,radiation failed to induce up-erpression of survivin at both mRNA and protein levels after transfection with HIF-1α siRNA.Conclusion HIF-1α-Survivin pathway is activated in human lymphoma cells after radiation,which might be involved in the cell radioresistance.

Approaching an advantage in TCM and Chinese herbs, comparing the difference between them in many ways. TCM has macroscopic advantage and microcosmic disadvantage. Point out that only the theory of TCM be respected, the advantages of TCM can be kept.

The paper indicates the clinic ethical problems that AIDS brings and the countermeasures according-

Objective:To investigate the effect of meglumine adenosine cyclophosphate combined with Shenmai injection on the balance of Th1/Th2 cells in the patients with bronchial asthma. Methods:Totally 75 cases of patients with bronchial asthma were ran-domly divided into the treatment group (38 cases) and the control group (37 cases). The control group was treated with the conven-tional therapy, while the treatment group was treated with meglumine adenosine cyclophosphate combined with Shenmai injection by in-travenous infusion additionally for 14 days. The level of Th1/Th2 cells was detected by flow cytometry, and the serum level of IL-10, IL-4 and IFN-γ was detected by enzyme-linked immunosorbent assay ( ELISA) before and after the treatment, and the clinical thera-peutic effect was assessed. Results:①Compared with that before the treatment, the expression level of Th1, Th1/Th2 and IFN-γwas increased in both groups, while the expression level of IL-4 and IL-10 was decreased after the treatment, and the changes in the treat-ment group were more notable than those in the control group (P<0. 05,P<0. 01). The expression level of Th2 in the two groups was decreased (P<0. 05,P<0. 01), and there was no significant difference between the groups (P>0. 05). ②The clinical efficiency of the treatment group was 94. 74%, while that of the control group was 83. 78%. The curative effect of the treatment group was better than that of the control group (P<0. 05). Conclusion:Meglumine adenosine cyclophosphate combined with Shenmai injection shows definitely clinical curative effect on bronchial asthma, and the mechanism may be related with regulating the imbalance expression level of Th1/Th2 and inflammatory cytokines.

0.05).The bed confine time,discharging time and postoperative complications in femoral head replacement group were superior over internal fixation group(P

OBJECTIVE To discuss the prevention and countermeasures of occupational bloodborne exposure risks in health care workers.METHODS The data of the exposure materials,and the management measure were collected.RESULTS Totally 397 people were exposed to hematogenous exposure injury,of which 96 doctors people,and 301 nurses,but no one got infection disease.CONCLUSIONS Good management can prevent the injury caused by occupational exposure.

Objective To observe noninvasive positive pressure ventilation with type Ⅱ respiratory failure treatment effect in the combined treatment of acute exacerbations of chronic obstructive pulmonary disease( COPD) . To explore the application value of noninvasive positive pressure ventilation in the treatment of COPD with type Ⅱrespiratory failure.And to provide clinical indications guidance for the better application of noninvasive positive pres-sure ventilation.Methods 60 cases of COPD with typeⅡrespiratory failure patients were collected as the research object.30 cases in each group were randomly divided into the control group and treatment group.Two groups of patients were given the treatment of expectorant,anti infection,thearapy according to the basis of disease and compli-cations.The control group were given nasal catheter oxygen.In the treatment group therapy and routine therapy com-bined with noninvasive positive pressure ventilation.Acute Physiology and Chronic Health Evaluation Ⅱ ( APACHE score Ⅱ) was used as the standard.The two groups were observed before and after treatment in the heart rate,respira-tory rate,blood gas analysis and clinical index changes.Results The patients in the two groups after treatment pH, PaO2,PaCO2 of blood gas indexes were better than before treatment,the difference was statistically significant(P<0.05).The treatment group improved more obviously compared with the control group (P<0.05).Compared with the control group,the treatment group patients hospitalization days,tracheal intubation and mortality declined or shorten, the differences were statistically significant (P<0.05).Conclusion Chronic obstructive pulmonary disease com-bined with type Ⅱ respiratory failure by using of noninvasive positive pressure ventilation at the same time, can improve the therapeutic effect in the conventional treatment.Noninvasive positive pressure ventilation reduces the inci-dence of complications and mortality.It is worthy of clinical reference.

Hematopoietic stem cell transplantation ( HSCT) technology has been widely used to cure some high-risk hematologic diseases and malignancies, with the rapid development of hematology and transplantation immunology, especially human leukocyte antigen matching technology. It might play an important role in biological therapy and gene therapy.

The innate immune system is critical to protect against microorganisms,but it is immature.Preterm newborn have to stay longer in NICU.They are vulnerable to infections.The common pathogen is coagulase-negative staphylococci which is the most cause of mortality for preterm newborn.So it is the key to understand the interaction between innate immune system of preterm newborn and pathogen.