Objective To study the clinical value of combined detection of CA125 and CA153 for diagnosis of endometrial carcinoma.Methods The combimed detection of CA125 and CA153 were performed in 36 patients with endometrial carcinoma,confirmed by pathological examination,on admission and 2-3 months after operation.Fifty-seven patients with uterine myoma,admitted for laparotomy in the same period and confirmed by pathology,were as controls.Results The sensitivity of combined detection of CA125 and CA153 for diagnosing endometrial carcinoma increased to 82.3% and the specificity decreased.Total accuracy rate of diagnosis reached 75.1%.There was statistical difference between the group of endometrial carcinoma and controls(P

Objective:To explore the therapeutic effect and safety of direct and selective percutaneous coronary inter-vention (PCI)in patients with ST elevation myocardial infarction (STEMI).Methods:A total of 138 STEMI pa-tients were randomly divided into direct PCI group (n=69,received PCI immediately after diagnosis)and selective PCI group (n=69,received acute thrombolysis therapy and then PCI in a selected time).Left ventricular ejection fraction (LVEF),peak creatine phosphokinase (CPK),CPK peak time,peak creatine kinase isoenzyme (CK-MB), CK-MB peak time,cardiac rupture rate during hospitalization,re-infarction rate and mortality rate within 30d and one year were compared between two groups.Results:Compared with selective PCI group after treatment,there were significant rise in LVEF [(49.3±6.8)% vs.(58.2±7.7)%],peak CPK [(74.9±49.3)IU/L vs.(113.0± 59.3)IU/L ]and peak CK-MB [(1983.1±1251.2)IU/L vs.(2588.6±1592.3)IU/L],and significant reduction in CPK peak time [(19.4±6.5)h vs.(13.9±4.5)h ]and CK-MB peak time [(19.7±7.7)h vs.(12.7±7.2) h]in direct PCI group,P <0.01 all;there were significant reductions in cardiac rupture rate (5.8% vs.0),re-in-farction rate (17.5% vs.6.3%)during hospitalization;mortality rates within 30d (11.0% vs.2.2%)and one year (22.2% vs.8.2%)in direct PCI group,P <0.05 all.Conclusion:Direct PCI in STEMI patients possesses better therapeutic effect and safety,which is worthy extending.

Objective To investigate the effects of prostaglandin E1 on proinflammatory and anti-inflammatory cytokines in sepsis patients.Methods One hundred and twenty cases of sepsis in ICU of our hospital were assigned to the groups:A,B,C and D,30 cases in each group.On the basis of conventional therapy,group A was added with prostaglandin El+ Xuebijing injection.The group was treated with prostaglandin E1,while the group C was treated with Xuebijing injection.The changes of APACHE Ⅱ score,Marshall score,anti-inflammatory and pro-inflammatory factors,mechanical ventilation time,ICU treatment time,28 d mortality rate in the 4 grups were observed and compared among 4 groups.Results The APACHE Ⅱ score and Marshall score after treatment in 4 groups were significantly decreased compared with before freatment (P＜0.05),Compared with the group B,C and D,The decrease of APACHE Ⅱ score,Marshace score,IL-1β,IL-6 and TNF-α levels was more significantly(P＜0.05),While the IL-10 level was significantly increastol(P＜0.05);duration of mechanical ventilation,length of stay ICU in were significantly shorter (P＜0.05),28 d mortality was significantly lower (P＜0.05).Conclusion Prostaglandin E1 combined with Xuebijing injection can effectively inhibit the inflammatory response in septic patients and promote the recovery of patients,reduces the mortality rate.

Fifty postoperative patients who suf- fered esophageal carcinoma were divided randomly into two groups.They received either enteral nutrition(Group EN,n=2 7) or parenteral nutrilion(Group PN,n=2 3) . The provisions of calorie and nitrogen were equal in the two groups.Nutrition support was started on the first postoperative day and continued for8days.The weight plas- ma proteins,immunological parameters and nitrogen balance were evaluated.The re- sults showed that there was no significant difference in body weight and serum albu- min level between the two groups.The pos- itive nitrogen balance were reached in both groups on the8th day.The CD4+percents age,the ratio of CD4+/ CD8+and NK cell activity were elevated,The conclusion is that the values of both EN and PN are sati- factory.In contrast with PN,EN has the advantages of physiological concordance and low cost.

OBJECTIVE: To investigate the changes and determine the difference of electrode impedance and neural response telemetry ( NRT) value with cochlear implants in children with malformed inner ear and normal inner ear. METHOD: Eighty-eight children with multi-channel cochlear implants participated in this study. Children were divided into malformed inner ear group and normal inner ear group. To test the electrode impedance values and NRT value. RESULT: The changes of electrode impedance showed the similar changing pattern in two groups. There was not different in electrode impedance values between the two groups (P > 0.05). The changes of electrode neural response telemetry values showed the similar changing pattern in two groups. There was significantly different in electrode impedance values between the two groups (P < 0.05). The NRT were going up higher from electrode 22 to electrode 1. CONCLUSION The values vary are different programming sessions and electrodes during the first 3 months of cochlear implant use. To acquire better hearing frequent programming sessions are necessary.
Adolescent ; Case-Control Studies ; Child ; Child, Preschool ; Cochlear Implantation ; Cochlear Implants ; Cochlear Nerve ; Ear, Inner ; abnormalities ; physiopathology ; surgery ; Electric Impedance ; Electrodes ; Female ; Humans ; Infant ; Male

Adult ; Crown Lengthening ; Dental Restoration, Permanent ; Esthetics, Dental ; Female ; Humans ; Incisor ; Malocclusion ; therapy

Objective To analyze the clinical characteristics of systemic lupus erythematosus (SLE) patients with septic arthritis.Methods Twelve SLE patients with septic arthritis admitted to Peking Union Medical College Hospital from January 1990 to December 2012 were retrospectively analyzed.Results The median duration from onset of SLE to septic arthritis was 8.5 months (ranged from 1 to 120 months).All patients had received higher doses of steroid therapy (equal to prednisolone 1 mg ·kg-1 ·d-1) and immunosuppressant,and 5 of them had received methylprednisolone pulse therapy.The infectious manifestations included joint pain (all cases),swelling (5 cases),reduced joint function (8 cases) and fever (10 cases).All patients were oligo-arthritis.The hip and knee joints were most commonly involved.Three patients were infected by Salmonella,4 patients were infected by S.aureus,and 3 patients were infected by tuber culosis.Conclusion When SLE patients with long term steroid and immunosuppressant therapy developedacute joint pain and swelling,septic arthritis should be considered.Synovial fluid Gram stain,culture,blood culture and arthroscopy should be performed promptly.Appropriate antibiotics should be administered,and early treatment can improve the outcomes.

ObjectiveTo explore the etiology of incisional hernia of abdomianal wall.Methods98 cases with incisional hernia were analyzed retrospectively in terms of incision type, technique of suture, suture materials,infection of incision, and the time of occurrence.ResultsLongitudinal incision, improper technique of suture,infection, increase of intraabdominal pressure, and diabetes mellitus were risk factors of incisional hernia. ConclusionsTransverse incision, prevention of infection of the incision, strict aseptic manipulation and hemostasis were effective in the prevention of incisional hernia. Most hernia developed within 6 months postoperatively.

A number of studies have shown that migraine, particularly migraine with aura, has certain correlation with stroke.However, their related potential mechanism remains unclear. Migraine may be a cause and/or a risk factor for stroke. Stroke may cause the occurrence of migraine, and it may also be a disease with two clinical manifestations.

Objective To explore the mechnism of toxicity induced by cisplatin on renal proximal tubular cells(RPTC) line and anti-apoptosis mechanism of BCL-2 with transfection of different mutant BCL-2 in vitro.MethodsRPTC was translocated with different mutants BCL-2(s).Cell apoptosis induced by cisplatin on RPTC was analyzed with confocal and flurencent microscope.The cell apoptosis was measured with Hoechst33258 after treatment with cisplatin.Results Different mutant BCL-2(BCL-acta,BCL-cb5)were translocated on mitochondrial and Endoplasmic Reticulum(ER) respectively.BCL-acta protected RPTC from apoptosis induced by cisplatin more easily than BCL-cb5 group in a time-dependant manner(P