1.Hyperthermia differentially affects specific human stem cells and their differentiated derivatives.
Si WANG ; Fang CHENG ; Qianzhao JI ; Moshi SONG ; Zeming WU ; Yiyuan ZHANG ; Zhejun JI ; Huyi FENG ; Juan Carlos Izpisua BELMONTE ; Qi ZHOU ; Jing QU ; Wei LI ; Guang-Hui LIU ; Weiqi ZHANG
Protein & Cell 2022;13(8):615-622
2.ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells.
Hongyu LI ; Zeming WU ; Xiaoqian LIU ; Sheng ZHANG ; Qianzhao JI ; Xiaoyu JIANG ; Zunpeng LIU ; Si WANG ; Jing QU ; Weiqi ZHANG ; Moshi SONG ; Eli SONG ; Guang-Hui LIU
Protein & Cell 2020;11(9):688-695
3.APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation.
Hongkai ZHAO ; Kuan YANG ; Yiyuan ZHANG ; Hongyu LI ; Qianzhao JI ; Zeming WU ; Shuai MA ; Si WANG ; Moshi SONG ; Guang-Hui LIU ; Qiang LIU ; Weiqi ZHANG ; Jing QU
Protein & Cell 2023;14(12):908-913
4.4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis.
Yifang HE ; Qianzhao JI ; Zeming WU ; Yusheng CAI ; Jian YIN ; Yiyuan ZHANG ; Sheng ZHANG ; Xiaoqian LIU ; Weiqi ZHANG ; Guang-Hui LIU ; Si WANG ; Moshi SONG ; Jing QU
Protein & Cell 2023;14(3):202-216
Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown. Here, we report that the expression of 4E-BP1 decreases along with the senescence of human mesenchymal stem cells (hMSCs). Genetic inactivation of 4E-BP1 in hMSCs compromises mitochondrial respiration, increases mitochondrial reactive oxygen species (ROS) production, and accelerates cellular senescence. Mechanistically, the absence of 4E-BP1 destabilizes proteins in mitochondrial respiration complexes, especially several key subunits of complex III including UQCRC2. Ectopic expression of 4E-BP1 attenuates mitochondrial abnormalities and alleviates cellular senescence in 4E-BP1-deficient hMSCs as well as in physiologically aged hMSCs. These f indings together demonstrate that 4E-BP1 functions as a geroprotector to mitigate human stem cell senescence and maintain mitochondrial homeostasis, particularly for the mitochondrial respiration complex III, thus providing a new potential target to counteract human stem cell senescence.
Mesenchymal Stem Cells/physiology*
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Cellular Senescence
;
Homeostasis
;
Cell Cycle Proteins/metabolism*
;
Adaptor Proteins, Signal Transducing/metabolism*
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Mitochondria/metabolism*
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Electron Transport Complex III/metabolism*
;
Humans
;
Cells, Cultured
5.Correction to: Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction.
Si WANG ; Zheying MIN ; Qianzhao JI ; Lingling GENG ; Yao SU ; Zunpeng LIU ; Huifang HU ; Lixia WANG ; Weiqi ZHANG ; Keiichiro SUZUIKI ; Yu HUANG ; Puyao ZHANG ; Tie-Shan TANG ; Jing QU ; Yang YU ; Guang-Hui LIU ; Jie QIAO
Protein & Cell 2022;13(8):623-625
6.FTO stabilizes MIS12 and counteracts senescence.
Sheng ZHANG ; Zeming WU ; Yue SHI ; Si WANG ; Jie REN ; Zihui YU ; Daoyuan HUANG ; Kaowen YAN ; Yifang HE ; Xiaoqian LIU ; Qianzhao JI ; Beibei LIU ; Zunpeng LIU ; Jing QU ; Guang-Hui LIU ; Weimin CI ; Xiaoqun WANG ; Weiqi ZHANG
Protein & Cell 2022;13(12):954-960
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