Henoch-schonlein purpura nephritis (HSPN)is the most common pediatric secondary renal glomerular disease.It could play an important role in the pathogenesis and progression of HSPN that regulatory T cells decline in the children and that the differentiation of Th17 cells are maybe not able to be effectively inhibited,leading to the insufficient immunosuppressive effect and the Th17 cells overexpression.We could further study the correlation among HPSN and the quantity and functional imbalance of Th17 cells and regulatory T cells to provide more theoretical basis for clinical treatment of HSPN.

OBJECTIVE:To provide suggestions for solving the problem of hospital pharmacy waiting time for medicine. METHODS:The definition and classification of the response time in hospital pharmacy dispensing process were introduced. The re-sponse time was considered to analyze the causes of waiting time for medicine in outpatient pharmacy and central pharmacy. The scheme for shortening the waiting time for medicine were put forward. RESULTS&CONCLUSIONS:The response time can be di-vided into 2 types,i.e. relative invariable and relative variable;the former results from hardware factor,system factor and other factors,and is relative stable and hardly changed;the latter results from that the speed of previous step is higher than that of next step,and can be changed by certain method,such as adjusting the proportion of manpower allocation,adjusting manpower tempo-rarily. Based on the concept of response time,the essence of waiting time for medicine can be understood accurately and deeply, and countermeasure can be found out fundamentally and used for other steps as prescribing prescription.

Objectives To study the suicide attempts and suicide attitude status and the characteristics of Medical University undergraduates, provide specific recommendations for mental health education and counseling. Methods The investigation was conducted among 567 undergraduates and 130 graduate students in Kunming Medical University with Self-designed Suicide Attempts Investigation and Suicide Attitude Questionnaire (QSA), and the results of different groups were compared. Results 14.46%undergraduates had suicidal ideation, 4.23%undergraduates had suicide attempts, but there were no significant different between female and male. The suicide attitude in general was contradictory and neutral. Sex,academic qualification,grade, family location and economic status variables had influence on suicide attitude. Conclusions Although the medical university undergraduates disapproved of the suicidal behavior, but it still reflected the pursuit and respect for the humanistic concern and value of life to a certain extent.Suicidal attitude had significant different in demographic variables.

Both microRNA and DNA methylation are the important contents of epigenetic modification.Lots of studies have confirmed that mutual regulation of microRNA and DNA methylation involve in tumorgenesis and development of cancer.The studies of their mechanisms bring some new ideas for investigating the pathogenesis of tumors,and provide a theoretical basis for the early diagnosis and treatment.

The comorbidity of pain and depression is common. Both disorders might share common neuroanatomical and molecu-lar mechanisms. Recent studies have found that the brain-de-rived neurotrophic factor( BDNF) ,which plays an important role in the process of pain-depression comorbidity, has gradually be-come a hot topic and target of treatment. The article mainly sum-marizes the mechanism underlying comorbid pain and depres-sion,as well as the significance of blood BDNF in diagnosis and treatment of pain and depression.

Breast milk, whether the ratio of nutritional ingredients or immunological characteristics, were the most suitable for physiological needs of preterm infants. However, breast milk composition was in dynamic change, causing imbalance of energy, which could not make the premature infant to achieve the desired growth state. Human milk fortifier, retaining advantages of the breast milk, promoted growth of premature infants further. This review primarily focused on two ways of adding human milk fortifiers, standardization fortification and targeted fortification. The former was widely used in neonatal intensive care unit, while the latter was more able to explore the growth of premature infant potentially, and to achieve a more ideal ectopic growth rate. With the development of breast milk bank, storage and component extraction technology brought about donor human milk-based human milk fortifier, which provided new directions of very low birth weight infants and very preterm infants breastfeeding. The progress of human milk fortification of premature infants was closely related to expansion of multi-disciplinary centers, and only the harmonious development of multi-center maked things much more rational and systematic.

OBJECTIVE:To provide reference for rational use of drugs in patients with mental disorders. METHODS:In retro-spective investigation,47 386 prescriptions of psychiatric department in our hospital during Sept. 2013 to Aug. 2014 were analyzed statistically. RESULTS:Totally 39 496 cases were enrolled in the 47 386 prescriptions. The median age of patients was 31.42,with male to female ratio of 1:1.07;they were diagnosed as schizophrenia and other mental disorder,accounting for 65.34%,and fol-lowed by mood disorders,accounting for 15.20% . They were mainly given single drug and two-drug use,accounting for 30.80%and 61.68%respectively. Clozapine,quetiapine,risperidone were top 3 prescription drugs in the list of frequency;olanzapine,que-tiapine,risperidone were top 3 drug in the list of consumption sum. Among top 20 psychiatric prescription drugs,there were 7 kinds of drugs for schizophrenia and other psychiatric disorders,3 kinds of drugs for mood disorders. CONCLUSIONS:The use of antipsychotic drugs in our hospital is rational basically.

Soft aid for health has become an important component of China's foreign aid. Soft aid for health with a focus on human resources development reflects the core spirit and the innovative mechanism of China's foreign aid. This paper examines three different types of aid for health human resources: medical assistance teams, govern-ment scholarships for students from developing countries, and health training courses for officials from developing countries. It also argues that China's foreign aid exposes problems, including insufficient strategic planning, non-in-volvement of civil society and NGOs, and lack of research on China's soft aid practices. In this paper, we suggests that to improve the effectiveness of foreign aid, the government should improve its strategic planning for aid, ensure the full public participation, strengthen the academic research, and improve knowledge sharing.

ObjectiveTo investigate the effect of Bobath approach combined with acupuncture on spastic cerebral palsy. Methods30 children with cerebral palsy treated with acupuncture combined with Bobath approach were as study group, other 30 children treated with Bobath approach only as the control group. ResultsThere were 27 cases (93%) were effective in study group, and 21 cases (80%) in control. The scores of Gross Motor Function Measure (GMFM) improved in both groups (P＜0.05), but more in the study group (P＜0.05) after treatment. The spasticity alleviated in both study group (76.7%) and control group （50%）. ConclusionThe combination with acupuncture is more effective on spastic cerebral palsy than Bobath approach alone.

Objective To investigate the regulatory effect of insulin-like growth factor binding protein 7 (IGFBP7) on the synthesis and secretion of fibronection and the inhibiting effect of anti-IGFBP7 antibody on apop-tosis of hepatic stellate cell-T6 (HSC-T6). Methods HSC-T6 cultured in vitro were divided into blank control group, IGFBP7 20 μg/L group, anti-IGFBP7 antibody 0.25 mg/L group, anti-IGFBP7 antibody 0.50 mg/L group and anti-IGFBP7 antibody 1.00 mg/L group. HSC-T6 were treated by IGFBP7 for 24 hours, then the expression of fibronectin was detected by Western blot and the content of fibronectin by ELISA. After incubating HSC-T6 with anti-IGFBP7 antibody for 14 hours, the inhibiting effect of anti-IGFBP7 antibody on HST-T6 was evaluated by MTT assay, and the effect of anti-IGFBP7 on the apoptosis of HST-T6 was detected by flow cytometry. All data were analyzed by one-way ANOVA, t test and SNK-q test. Results The content and expression of fibronection in IGFBP7 20 mg/L group were significantly higher than those in the blank control group (t = 22.06, 7.43, P < 0.05). Anti-IGFBP7 antibody had an obvious inhibiting effect on the proliferation of HSC-T6 (F=14. 70, P < 0.05), and it also enhanced the ratio of apoptosis of HSC-T6 (F = 63.79, P < 0.05). Conclusions IGFBP7 can increase the synthesis and secretion of fibronectin which is the principal component of extracellular matrix. Anti-IGFBP7 antibody can inhibit the proliferation and promote the apoptosis of HSC-T6.