Objective: To compare the efficacy of photodynamic diagnosisassisted transurethral resection of bladder tumor (TURB) with conventional white light imaging-assisted TURB in primary nonmuscle- invasive bladder cancer. Methods: Cochrance Libarary, PubMed, Embase, Wanfang Data, VIP Data and Chinese BioMedical Literature Database (CBM). The endpoints were 3-month, 9-month, 1-year, 2-year and 5-year biochemical failure rates. After evaluating the quality of the included literatures and extracting the data, the Metaanalysis was performed using Review Manager 5.3 software. The results were expressed as risk ratio (RR) with the corresponding 95% confidence interval (CI). Results: The final analysis included ten studies including 2 430 patients. The 9-month (RR: 0.80,95% CI: 0.69-0.93; P = 0.005), 1-year (RR: 0.65, 95% CI: 0.46-0.91; P = 0.010), 2-year (RR: 0.54, 95%: CI: 0.40-0.72; P < 0.001) and 5-year (RR: 0.76, 95% CI: 0.61-0.94; P = 0.010) biochemical failure rates were lower in patients who received photodynamic diagnosisassisted TURB. Conclusion: The efficacy of photodynamic diagnosis-assisted TURB is superior to conventional white light imaging-assisted in efficacy of primary non-muscle-invasive bladder cancer in 5 years.

Objective The purpose of this work was to compare the efficacy of narrow band imaging-assisted transurethral resection of bladder tumour (TURB) with conventional white light imagingassisted TURB in primary non-muscle-invasive bladder cancer.Methods Several databases were searched,including Cochrance Libarary,PubMed,Embase,Wanfang,VIP,CNKI and CBM.The endpoints were biochemical failure in 3 months,1 year and 2 years.We performed a meta-analysis of the published data.The results are expressed as risk ratio (RR),with the corresponding 95％ confidence interval (CI).Results The final analysis included seven trials comprising 1889 patients.Biochemical failure in 3months (RR0.73,95％ CI 0.55-0.96;P =0.02),1 year(RR 0.69,95％ CI 0.58-0.80;P ＜ 0.01) and 2 years (RR 0.58,95％ CI 0.41-0.82;P =0.002) were fewer in patients who received narrow band imagingassisted TURB.The recurrence rates of 3 months,1 year and 2 years were 14.44％,29.35％ and 30％ in white light imaging group.The recurrence rates of 3 months,1 year and 2 years were 3.61％,9.35％ and 12.59％ lower in narrow band imaging group compared with white light imaging group.Conclusions Narrow band imaging-assisted TURB was superior to conventional white light imaging-assisted TURB in primary non-muscle-invasive bladder cancer in 2 years.