Disc degeneration disease (DDD) is the major cause of lower back pain, resulting in significant serious social problems and economic burdens due to its high mortality rate and disability rate. Currently available clinic treatments are inefficient for solving spinal structure and function insufficiency caused by the DDD, especially for patients with degenerated or broken anulus fibrosus. Tissue engineering provides a promising and available strategy to regenerate a new anulus fibrosus with complete bio-functions. This review following primary introduces the current research progress and the potential development orientation of tissue engineering anulus fibrosus.
Animals ; Humans ; Intervertebral Disc ; physiopathology ; Intervertebral Disc Degeneration ; physiopathology ; therapy ; Lumbar Vertebrae ; physiopathology ; Mesenchymal Stem Cell Transplantation ; methods ; Tissue Engineering ; methods ; Tissue Scaffolds