Objective To elucidate the association of plasma factor Ⅷ oagulant activity(FⅦc)with me risk of myocardial infarction (MI) and to assess the influence of factor Ⅶ gene Mspl polymorphism and lipid metabolism on FⅦc in the Chinese. Methods A total of 137 patients with angiographically confirmed MI and 125 healthy individuals were evaluated retrospectively. Plasma FⅦC was measured by one-stage prothrombin time,and FⅦ genotype was determined after Mspl digestion of polymerase chain reaction-amplified genomic DNA.Serum lipidlevels were assessed by routine methods.Results MI patients had significantly higher levels of FⅦc (119.5%±22.7% vs 99.9%±21.8%,P＜0.01) and total serum cholesterol (5.80±1.06mmol/L vs 5.53±1.08 mmol/L, P＜0.05) than controls, but only FⅦc independently correlated with the risk of MI (OR=1.04, P＜0.01). There were no significant differences in FⅦ genotype or allele frequency between patients and controls (P＞0.05).Subjects with the Gln353 allele were associated with significantly lower FⅦc levels than Arg353homozygotes (99.7%±19.3% vs 111.4%±24.6%,P＜0.05). Serum triglyceride was positively correlated with plasma FⅦc in both control(r=0.25, P＜0.01)and case (r=0.87, P＜0.01) groups, but this correlation was restricted to Arg/Arg genotypa (r=0.68, P＜0.01).A significant correlation of total serum cholesterol with FⅦc only appeared in Arg/Arg homozygotes (r=0.17, P＜0.01). Conclusions Our findings support the role of plasma FⅦc as a risk factor for MI in Chinese. Plasma triglyceride and FⅦ gene Mspl pclymorphism are two independent determinants of FⅦc. Assay of this polymorphism will be helpful in determining who will benefit most from lipid-lowing therapy.

Objective:To explore the effect of emergency "zero channel" process on improving the efficiency of intravenous thrombolysis in stroke.Methods:Fifty-eight acute ischemic stroke patients admitted to our hospital from January 2020 to December 2020 were enrolled into experimental group; another 58 acute ischemic stroke patients admitted to our hospital from January 2019 to December 2019 and matched with age and gender were selected as control group. "Green channel" process was adopted for patients in the control group, and optimized "zero channel" process (moving the working passageway forward to the ambulance) was implemented for patients in the experimental group. Door to rescue room time (DRRT), door to consultation time (DCT), door to laboratory examination completion time (DLECT), door to CT report time (DCRT), and door to needle time (DNT) were used to evaluate the times of emergency treatment. The thrombolytic effect of the two groups was compared by evaluating the recanalization rate of occluded vessels and thrombolytic efficiency. Modified Rankin scale (mRS) was used to evaluate the prognoses 6 months after treatment in both groups, and mRS scores≤2 was defined as good prognosis.Results:The DCRT, DCT and DNT in the experimental group were significantly shorter than those in the control group ( P<0.05); the compliance rate of DNT≤60 min in the experimental group was significantly higher as compared with that in the control group ( P<0.05). The immediate recanalization rate of occluded vessels in the experimental group and control group was 60.3% and 27.6%, and the thrombolytic efficiency was94.83% and 82.76%; significant differences were noted between the two groups ( χ2=12.633, P<0.001; χ2=4.245, P=0.039). The good prognosis rate of the experimental group and control group was 36.2% and 15.5%, respectively, after 6 months of follow-up ( χ2=4.016, P=0.041). Conclusion:Emergency "zero channel" can further shorten DCT, DCRT, and DNT, and improve the efficiency of thrombolysis and prognoses of acute ischemic stroke patients.