Large vessel occlusion (LVO) is a common vascular event in acute ischemic stroke. It is recommended to carry out endovascular therapy as soon as possible to save ischemic penumbra. Thus it is of great importance to identify the pre-hospital patients with LVO. At present, there are many LVO screening tools for prehospital settings, such as Los Angeles Motor Scale, Cincinnati Prehospital Stroke Severity Scale, the Rapid Arterial oCclusion Evaluation scale and so on. We will review the research advances on LVO screening tools to improve the clinical work.

Objective To investigate the changes of cortical thickness in patients with insomnia disorder(ID).Methods High-resolution MRI data were collected from 32 ID patients(ID group)and 30 healthy controls(HC)(HC group).The cortical thickness of both groups were analyzed using statistical parametric mapping 12(SPM12)software,while considering age,gender,and educational level as covariates.The cortical thickness in brain regions showed statistically significant differences was extracted for Pearson's correla-tion analyses with sleep and mood-related scales.Results Compared with the HC group,the ID group exhibited significantly decreased cortical thickness in brain regions such as the left insula,fusiform gyrus,orbitofrontal lobe,superior temporal gyrus,middle temporal gyrus,lateral occipital lobe and right caudal anterior cingulate gyrus[P＜0.05,family-wise error(FWE)correction].Furthermore,reduced cortical thickness of the cingulate gyrus was negatively correlated with the Pittsburgh sleep quality index(PSQI)score(r=-0.437,P=0.012).Conclusion The cortical thickness of several brain regions associated with sleep and mood are significantly reduced in patients with ID,providing potential neuroimaging evidence for understanding the pathophysiological mechanism of ID.