1.Effects of mesalazine combined with Xianglian pills on cytokines and immunocytes in ulcerative colitis
Chinese Journal of Biochemical Pharmaceutics 2016;36(6):148-150
Objective To investigate the effects of mesalazine combined with Xianglian pills on cytokines and immunocytes in ulcerative colitis. Methods A total of 86 patients with ulcerative colitis from our hospital were collected and randomly divided into experimental group and control group with 43 cases in each group.Patients in the control group were treated by mesalazine, patients in the experimental group were treated by mesalazine combined with Xianglian pills treatment.The cytokines and immunocytes levels and efficacy between two groups were compared.Results After treatment, the clinical effective rate of the control group 69.77% was lower than the experimental group 88.37%, with statistical significance ( P <0.05 );compared with the control group, the TNF-αlevel of the experimental group was lower than the control group, IL-2, IL-4 and IL-10 levels were higher than the control group;the serum TFF1 and TFF3 levels were higher than the control group;CD3 +, CD4 +/CD8 +and NK cells levels were higher than the control group, the level of CD8 +was lower than the control group, with statistical significance ( P<0.05 ) .Conclusion Mesalazine combined with Xianglian pills in the treatment of patients with ulcerative colitis could reduce the inflammatory reactions and improve the clinical efficacy, with lower adverse reactions.
2.Combined application of vascularized pedicled pectoralis major clavicular periosteal flap and locking plate fixation plus bone morphogenetic protein implantation in the treatment of clavicular defect and nonunion after operation
Chinese Journal of Trauma 2009;25(9):826-828
Objective To investigate the clinical characteristics of clavicular defect and nonunion after operation and evaluate the clinical effects of vascularized pedicled pectoralis major clavicular periosteal flap and locking plate fixation plus bone morphogenetic protein (BMP) implantation. Methods From January 2004 to April 2008, 12 patients (mean age, 42.8 years old) with clavicular defect and nonunion were treated in Zhongshan Hospital. The internal fixators were removed, and then fibrous scars and sclerotic bones were cleared. The clavicular detects were fixed with locking plate, with implantation of the BMP. The wound was covered with vascularized pedicled pectoralis major clavicular periosteal flap. Postoperative functional rehabilitation exercises were performed. Results All patients were followed up for 8-24 months (mean 1.2 years). The clinical results were evaluated by Constant-Murley scoring system. The clavicular defects were healed in all patients within 4-7 months, and the internal fixators were successfully removed from some of the patients. Conclusions Vascularized pedicled pectoralis major clavicular periosteal flap combined with locking plate fixation plus BMP implantation is effective in the treatment of clavicular defect and nonunion.
3.Comparative Analysis of Laparoscopic Versus Open Surgery in Obese Patients with Appendicitis
Chinese Journal of Minimally Invasive Surgery 2014;(10):903-905
Objective To analyze the clinical effects, as well as its advantages and disadvantages, of laparoscopic surgery for appendicitis in obese patients. Methods Clinical data of 80 obese patients receiving appendectomy, including 38 cases of open appendectomy and 42 cases of laparoscopic appendectomy, were analyzed retrospectively.The operative time, blood loss, analgesic and antibiotic use, postoperative fever, postoperative complications, length of hospital stay, and hospitalization cost were compared between the two operative methods. Results Conversions to open surgery were required in 2 patients in the laparoscopic group. There was no significant difference in operative time between the 2 groups (P >0.05).Compared with the open group, the laparoscopic group had less blood loss [(14.98 ±12.77) ml vs.(31.58 ±19.00) ml, t=-4.550, P=0.000], shorter time of postoperative antibiotic use [(2.7 ±1.0) d vs.(4.1 ±1.2) d, t=-5.470, P=0.000], less postoperative analgesics needed [5.0%(2/40) vs.26.3%(10/38),χ2 =6.802, P=0.009], less drainage [2.5% (1/40) vs.18.4% (7/38), χ2 =5.367, P=0.021], less postoperative fever [5.0%(2/40) vs.23.7%(9/38),χ2 =5.616, P=0.018], less postoperative wound healing [5.0%(2/40) vs.21.1%(8/38),χ2 =4.493, P=0.034], and shorter hospital stay [(5.9 ±3.2) d vs.(8.7 ±4.1) d, t=-3.345, P=0.001], but the higher cost of hospitalization [(7800 ±396) yuan vs.(4914 ±434) yuan, t=30.716, P=0.000]. Conclusion For obese patients with appendicitis, laparoscopic appendectomy has less surgical trauma, faster recovery, less postoperative pain, fewer complications,and shorter hospital stay, being a preferred method of treatment.
4.Teaching practice and normalization construction of the elective course of hyperbaric oxygen medicine
Chinese Journal of Medical Education Research 2012;11(4):397-399
The importance of course arrangement and standardization construction for the course of hyperbaric oxygenation medicine was expounded in this review.In addition,the measures and experiences on textbook choosing,teaching content assignment,teaching methods designing,assessment means innovation and teaching personnel training were also discussed.The teaching system of the course of hyperbaric oxygenation medicine can be improved and references for thc dcvelopment of clinical hyperbaric oxygenation medicine courses can be provided through these measures.
6.Optimization of Solid State Fermentation of Endo-mannanase Production by Bacillus subtilis
Microbiology 1992;0(01):-
Bacillus subtilis is a good producer of mannanase.This is the first study to investigate mannanase production under solid state fermentation(SSF) by Bacillus subtilis.Bacillus subtilis WY34 was used for the production of extracellular mannanase in the SSF of wheat bran.The highest mannanase activity was 7,650 U/g dry matter when the following conditions were used: wheat bran 5g,initial moisture content 71%,Tween-80 1%,konjac powder 0.4 g,initial pH 7.0,incubation temperature 50 ℃.Enzyme production was increased 178% after optimization.
7. The association between breast carcinoma and columnar alteration with prominent apical snouts and secretions
Academic Journal of Second Military Medical University 2010;28(4):369-371
Objective: To study the pathological characteristics of columnar alteration with prominent snouts and secretions (CAPSS) and its relationship with incidence of breast carcinoma. Methods: One hundred forty-four CAPSS specimens identified by breast core needle biopsies(CNB) were retrospectively evaluated. The CAPSS specimens were subdivided into lesions with (n=108) and without (n=36) atypical ductal hyperplasia and their pathological findings were compared. Results: In situ and invasive carcinomas were found in 21.5% (31/144) of the specimens, including those with and without atypical hyperplasia. We also found that specimens with atypical hyperplasia had a higher malignant incidence than those without atypical hyperplasia (P=0.001). Conclusion: CAPSS, especially when with atypical ductal hyperplasia, are associated with breast carcinoma.
8.Positive impact of letting patients pick their doctors on medical quality
Xinli ZHENG ; Zhi DU ; Qiang LI
Chinese Journal of Hospital Administration 1996;0(06):-
Firstly the paper expounds the fact that letting patients pick their doctors goes with the tide of social development: ①the connotation of medical quality determines the necessity of patients involvement; ②evaluation of medical quality has extended from self appraisal to social assessment; and ③the mechanism of letting patients pick their doctors conforms to the medical quality requirements of the times. Then the paper discusses the positive impact of letting patients pick their doctors on medical quality, including the choice of doctors by outpatients and the impossibility of doing so in medico technical and emergency departments or by inpatients. The paper also gives an account of the measures taken for safeguarding medical quality when adopting the practice of letting patients pick their doctors. Lastly the paper explains the boosting role of the practice and the difference between letting patients pick their doctors and letting them name particular surgeons for their operations.
9.Interventional therapy of the complications after liver transplantation:uncommon complications
Lin-Sun LI ; Zheng-Qiang YANG ;
Journal of Interventional Radiology 2006;0(08):-
In addition to the common complications involving hepatic artery, hepatic vein and biliary tract, which have already been mentioned and discussed in the preceding parts of this article, there are some uncommon complications which have been reported in the medical literature as the case report or as the case- series analysis. This paper sums up these uncommon complications. Part of these uncommon complications can be treated with interventional therapy. It is very important for interventional radiologists to make a further understanding of the different etiology of these uncommon complications occurred after liver transplantation so as to get a comprehensive knowledge about the complications after liver transplantation.
10.Advances in Bioreactor Structure Innovation and Related Studies
Jiang-Wei TANG ; Zheng-Qiang WU ;
China Biotechnology 2006;0(05):-
Bioreactor is a key equipment in bioengineering.The bioprocessing efficiency using bioreactors is significantly affected by the reactor configuration.It is apparent that research on the bioreactor structure is one of key issues in bioengineering.Along with industrialization of penicillin mechanically stirred bioreactor was developed,after that large quantity of bioreactors was invented for the sake of the development of mammal and plant cell cultivation,epiphyte cultivation and algae cultivation.Among these bioreactors mechanical stirred bioreactors and airlift bioreactors are very popular.Recent trends of studies on mechanically stirred bioreactors and airlift ones were reviewed.The focus is on the summarization and analysis of 11 kinds of novel bioreactors developed around the world.